Gene
tjp1a
- ID
- ZDB-GENE-031001-2
- Name
- tight junction protein 1a
- Symbol
- tjp1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within pigmentation and slit diaphragm assembly. Located in bicellular tight junction. Is expressed in several structures, including immature eye; nervous system; neural tube; pleuroperitoneal region; and tail bud. Orthologous to human TJP1 (tight junction protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 49 figures from 28 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb817 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh463 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| is86Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| pd1224Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| pd1252Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa7069 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13285 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20982 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34097 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40924 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tnh009b | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-tjp1a | (2) | |
| CRISPR2-tjp1a | (2) | |
| CRISPR3-tjp1a | (3) | |
| CRISPR4-tjp1a | (2) | |
| CRISPR5-tjp1a | (2) | |
| CRISPR6-tjp1a | Davison et al., 2024 | |
| MO1-tjp1a | N/A | Carrasco-Rando et al., 2019 |
| MO2-tjp1a | N/A | Carrasco-Rando et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | PDZ domain | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily | Tight junction protein ZO | ZO-1, SH3 domain | ZU5 domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QHT2 | InterPro | 1721 | ||||||||||
| UniProtKB:A0A8M2BG85 | InterPro | 1722 | ||||||||||
| UniProtKB:A0A8M3B198 | InterPro | 1721 | ||||||||||
| UniProtKB:A0A8M3B1A2 | InterPro | 1692 | ||||||||||
| UniProtKB:A0A8M3B464 | InterPro | 1725 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tjp1 | monoclonal | IgG1 , k | Mouse |
|
Life Technologies (Invitrogen)
Thermo Fisher Scientific (Lab Vision) |
239 | |
| Ab2-tjp1 | polyclonal | Rabbit |
|
Life Technologies (Invitrogen)
|
24 | ||
| Ab5-tjp1a | polyclonal | Rabbit |
|
2 | |||
| Ab4-tjp1a | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:tjp1a-mCherry) |
|
| 1 | Guo et al., 2018 | |
| Tg(myl7:tjp1a-EGFP) |
|
| Jiménez-Amilburu et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-1H4 | ZFIN Curated Data | |
| Encodes | EST | cb817 | Thisse et al., 2001 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009303250 (1) | 7305 nt | ||
| Genomic | GenBank:BX649429 (2) | 272478 nt | ||
| Polypeptide | UniProtKB:A0A8M3BB23 (1) | 1734 aa |
- Davison, C., Harzman, H., Nicholson, J., Entriken, S., Mobley, K., Krull, A., Singhal, M., Skow, C., Matthews, N., Kopp, L., Gillette, B., Weide, T.J., Hukvari, J.R., Stumpf, S.C.P., Feldmann, O.M., McGrail, M., Srivastava, R., Essner, J.J. (2024) Tagging the tjp1a Gene in Zebrafish with Monomeric Red Fluorescent Protein Using Biotin Homology Arms. Zebrafish. 21:191197191-197
- Yan, J., Fang, L., Ni, A., Xi, M., Li, J., Zhou, X., Qian, Q., Wang, Z.J., Wang, X., Wang, H. (2024) Long-Term Neurotoxic Effects and Alzheimer's Disease Risk of Early EHDPP Exposure in Zebrafish: Insights from Molecular Mechanisms to Adult Pathology. Environmental science & technology. 58(43):19152-19164
- Yin, J., Schellinx, N., Maggi, L., Gundel, K., Wiesner, C., Kotini, M.P., Lee, M., Phng, L.K., Belting, H.G., Affolter, M. (2024) Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1. Nature communications. 15:97149714
- Liu, Y., Zhu, D., Liu, J., Sun, X., Gao, F., Duan, H., Dong, L., Wang, X., Wu, C. (2023) Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish. Frontiers in nutrition. 10:10877031087703
- Cronan, M.R., Hughes, E.J., Brewer, W.J., Viswanathan, G., Hunt, E.G., Singh, B., Mehra, S., Oehlers, S.H., Gregory, S.G., Kaushal, D., Tobin, D.M. (2021) A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization. Cell. 184(7):1757-1774.e14
- Lasseigne, A.M., Echeverry, F.A., Ijaz, S., Michel, J.C., Martin, E.A., Marsh, A.J., Trujillo, E., Marsden, K.C., Pereda, A.E., Miller, A.C. (2021) Electrical synaptic transmission requires a postsynaptic scaffolding protein. eLIFE. 10:
- Levic, D.S., Yamaguchi, N., Wang, S., Knaut, H., Bagnat, M. (2021) Knock-in tagging in zebrafish facilitated by insertion into non-coding regions. Development (Cambridge, England). 148(19):
- McCluskey, B.M., Uji, S., Mancusi, J.L., Postlethwait, J.H., Parichy, D.M. (2021) A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots. PLoS Genetics. 17:e1009364
- Zhang, F.L., Yang, Y.L., Zhang, Z., Yao, Y.Y., Xia, R., Gao, C.C., Du, D.D., Hu, J., Ran, C., Liu, Z., Zhou, Z.G. (2021) Surface-Displayed Amuc_1100 From Akkermansia muciniphila on Lactococcus lactis ZHY1 Improves Hepatic Steatosis and Intestinal Health in High-Fat-Fed Zebrafish. Frontiers in nutrition. 8:726108
- Ma, X., Zhu, P., Ding, Y., Zhang, H., Qiu, Q., Dvornikov, A.V., Wang, Z., Kim, M., Wang, Y., Lowerison, M., Yu, Y., Norton, N., Herrmann, J., Ekker, S.C., Hsiai, T.K., Lin, X., Xu, X. (2020) Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity. Science advances. 6:eaay2939
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