Gene

tjp1b

ID

ZDB-GENE-070925-1

Name

tight junction protein 1b

Symbol

tjp1b Nomenclature History

Previous Names

tjp1.2 (1)
zo-1b (1)
si:dkey-33l14.1

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within gap junction assembly; protein localization to synapse; and synapse assembly. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including axial mesoderm; cardiovascular system; epidermis; nervous system; and pleuroperitoneal region. Orthologous to human TJP1 (tight junction protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tjp1b Human Ortholog

No data available

Associated With tjp1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000906	ZU5 domain
Domain	IPR001315	CARD domain
Domain	IPR001452	SH3 domain
Domain	IPR001478	PDZ domain
Domain	IPR008144	Guanylate kinase-like domain
Domain	IPR008145	Guanylate kinase/L-type calcium channel beta subunit
Domain	IPR035597	ZO-1, SH3 domain
Family	IPR005417	Tight junction protein ZO
Family	IPR005418	Tight junction protein ZO-1
Homologous_superfamily	IPR011029	Death-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	CARD domain	Death-like domain superfamily	Guanylate kinase-like domain	Guanylate kinase/L-type calcium channel beta subunit	PDZ domain	PDZ superfamily	P-loop containing nucleoside triphosphate hydrolase	SH3 domain	SH3-like domain superfamily	Tight junction protein ZO	Tight junction protein ZO-1	ZO-1, SH3 domain	ZU5 domain
UniProtKB:A0A8M9PZ36 InterPro	2040
UniProtKB:A0A8M9PHG3 InterPro	2030
UniProtKB:A0A8M9PZ42 InterPro	2028
UniProtKB:A0A8M9P6X7 InterPro	2031
UniProtKB:A0A8M6YYG5 InterPro	2015
UniProtKB:A0A8M9PVM8 InterPro	2038
UniProtKB:A0A8M9P6Y1 InterPro	2023
UniProtKB:A0A8M9P6Y5 InterPro	1788
UniProtKB:A0A8M9PHF8 InterPro	2043
UniProtKB:A0A8M3AWQ4 InterPro	2017
UniProtKB:A0A8M3B7C4 InterPro	1997
UniProtKB:A0A8M9PNF2 InterPro	1891
UniProtKB:A0A8M9PHG7 InterPro	1970
UniProtKB:A0A8M9PNE2 InterPro	2042
UniProtKB:A0A8M6YWL0 InterPro	2018
UniProtKB:A0A8M3AP85 InterPro	1938
UniProtKB:A0A8M3AZT7 InterPro	2029
UniProtKB:A0A8M9PVN3 InterPro	2025
UniProtKB:A0A8M3APU8 InterPro	2030
UniProtKB:A0A8M9PVN8 InterPro	1800

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tjp1b-201 (1) Ensembl	Ensembl	7,408 nt	Select Tool ZFIN BLAST
mRNA	tjp1b-202 (1) Ensembl	Ensembl	7,626 nt	Select Tool ZFIN BLAST
mRNA	tjp1b-203 (1) Ensembl	Ensembl	7,618 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tjp1	monoclonal	tjp1a tjp1b	IgG1 , k	Mouse	IHC	Life Technologies (Invitrogen) Thermo Fisher Scientific (Lab Vision)	236

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations