ZFIN is now using GRCz12tu for Genomic Data
Gene
tjp1b
- ID
- ZDB-GENE-070925-1
- Name
- tight junction protein 1b
- Symbol
- tjp1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within gap junction assembly; protein localization to synapse; and synapse assembly. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including axial mesoderm; cardiovascular system; epidermis; nervous system; and pleuroperitoneal region. Orthologous to human TJP1 (tight junction protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000906 | ZU5 domain |
| Domain | IPR001315 | CARD domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR035597 | ZO-1, SH3 domain |
| Family | IPR005417 | Tight junction protein ZO |
| Family | IPR005418 | Tight junction protein ZO-1 |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tjp1 | monoclonal | IgG1 , k | Mouse |
|
Life Technologies (Invitrogen)
Thermo Fisher Scientific (Lab Vision) |
245 |
Plasmids
No data available
- Genome Browsers