PUBLICATION
Apical Cell-Cell Adhesions Reconcile Symmetry and Asymmetry in Zebrafish Neurulation
- Authors
- Guo, C., Zou, J., Wen, Y., Fang, W., Stolz, D.B., Sun, M., Wei, X.
- ID
- ZDB-PUB-180615-13
- Date
- 2018
- Source
- iScience 3: 63-85 (Journal)
- Registered Authors
- Fang, Wei, Wei, Xiangyun
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 29901027 Full text @ iScience
Citation
Guo, C., Zou, J., Wen, Y., Fang, W., Stolz, D.B., Sun, M., Wei, X. (2018) Apical Cell-Cell Adhesions Reconcile Symmetry and Asymmetry in Zebrafish Neurulation. iScience. 3:63-85.
Abstract
The symmetric tissue and body plans of animals are paradoxically constructed with asymmetric cells. To understand how the yin-yang duality of symmetry and asymmetry are reconciled, we asked whether apical polarity proteins orchestrate the development of the mirror-symmetric zebrafish neural tube by hierarchically modulating apical cell-cell adhesions. We found that apical polarity proteins localize by a pioneer-intermediate-terminal order. Pioneer proteins establish the mirror symmetry of the neural rod by initiating two distinct types of apical adhesions: the parallel apical adhesions (PAAs) cohere cells of parallel orientation and the novel opposing apical adhesions (OAAs) cohere cells of opposing orientation. Subsequently, the intermediate proteins selectively augment the PAAs when the OAAs dissolve by endocytosis. Finally, terminal proteins are required to inflate the neural tube by generating osmotic pressure. Our findings suggest a general mechanism to construct mirror-symmetric tissues: tissue symmetry can be established by organizing asymmetric cells opposingly via adhesions.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping