FIGURE SUMMARY
Title

Analysis of a gene regulatory cascade mediating circadian rhythm in zebrafish

Authors
Li, Y., Li, G., Wang, H., Du, J., and Yan, J.
Source
Full text @ PLoS Comput. Biol.
Fig. 5

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EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagent:
Anatomical Term:
Stage Range: Day 4 to Day 5
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Day 4 to Day 5
Fig. 6

The circadian rhythm of melanogenesis in larval zebrafish.

(A) Images of 5 dpf WT larval melanocytes in 4 hour intervals over 24 hours under LD conditions. (B) The area of melanocytes in WT larvae showed robust circadian rhythm in LD starting at 4 dpf (p<0.001, Fisher′s g test). (C) Melanin concentrations of WT larvae showed robust circadian rhythm in LD while increasing with time (p<0.002, Fisher′s g test after detrend). (D) The rhythm of melanin concentration was abolished in clock morphants in LD conditions, while the rhythm in control morphants remained robust. (E) Under DD conditions, the circadian rhythms of melanin concentrations in clock morphants and control morphants were not significant.

PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage Range: Day 4 to Day 5
Fig. S2

Mitfa MO knock-down leads to loss of pigmentation in the trunk and smaller eyes. Phenotypes of WT (A–B), control morphants (C–D) and mitfa morphants (E–F) at 48 hpf are shown.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Comput. Biol.
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