Gene

mef2aa

ID

ZDB-GENE-990415-163

Name

myocyte enhancer factor 2aa

Symbol

mef2aa Nomenclature History

Previous Names

mef2a
etID309779.18 (1)
wu:fd19d02

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Enables transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including myofibril assembly; positive regulation of macromolecule metabolic process; and somitogenesis. Predicted to be located in nucleus. Is expressed in cardiovascular system; myotome; nervous system; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human MEF2A (myocyte enhancer factor 2A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

22 figures from 14 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55208 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mef2aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
coronary artery disease	Alliance	{Coronary artery disease, autosomal dominant, 1}	608320

Associated With mef2aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002100	Transcription factor, MADS-box
Domain	IPR022102	Holliday junction regulator protein family C-terminal
Domain	IPR033896	MADS MEF2-like
Family	IPR050142	MADS-box/MEF2 Transcription Factor
Homologous_superfamily	IPR036879	Transcription factor, MADS-box superfamily

Domain Details Per Protein

Protein	Length	Holliday junction regulator protein family C-terminal	MADS-box/MEF2 Transcription Factor	MADS MEF2-like	Transcription factor, MADS-box	Transcription factor, MADS-box superfamily
UniProtKB:A0A8M9PPZ2 InterPro	466
UniProtKB:A0A0R4IRM3 InterPro	460
UniProtKB:Q1LXH6 InterPro	458
UniProtKB:A0A8M9P9W4 InterPro	467
UniProtKB:A0A8M2B5M2 InterPro	503
UniProtKB:A0A8M9PLW4 InterPro	511
UniProtKB:A0A8M2B5Z6 InterPro	504
UniProtKB:A0A8M9PF86 InterPro	512
UniProtKB:A0A8M9PF89 InterPro	467
UniProtKB:A0A8M9P0X9 InterPro	468

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mef2aa-201 (1) Ensembl	Ensembl	1,736 nt	Select Tool ZFIN BLAST
mRNA	mef2aa-202 (1) Ensembl	Ensembl	1,844 nt	Select Tool ZFIN BLAST
mRNA	mef2aa-204 (1) Ensembl	Ensembl	1,733 nt	Select Tool ZFIN BLAST
mRNA	mef2aa-205 (1) Ensembl	Ensembl	2,113 nt	Select Tool ZFIN BLAST
mRNA	mef2aa-206 (1) Ensembl	Ensembl	2,103 nt	Select Tool ZFIN BLAST
mRNA	mef2aa-207 (1) Ensembl	Ensembl	2,124 nt	Select Tool ZFIN BLAST
mRNA	mef2aa-208 (1) Ensembl	Ensembl	1,873 nt	Select Tool ZFIN BLAST
mRNA	mef2aa-209 (1) Ensembl	Ensembl	1,963 nt	Select Tool ZFIN BLAST
ncRNA	mef2aa-005 (1) Ensembl	Ensembl	606 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-mef2	polyclonal	mef2aa mef2ca mef2cb mef2d	IgG	Rabbit	IHC	AnaSpec	5

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations