ZFIN ID: ZDB-GENE-030131-3133
Gene Name: basic helix-loop-helix family, member e40
Gene Symbol: bhlhe40    Nomenclature History

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Previous Names: bhlhb2, DEC1 (1), Dec1 (1), wu:fc28a06, wu:fm54h07, zgc:76913

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in circadian regulation of gene expression; locomotor rhythm; and negative regulation of transcription, DNA-templated. Predicted to localize to the nucleus. Is expressed in several structures, including cardiovascular system; digestive system; immature eye; nervous system; and pleuroperitoneal region. Orthologous to human BHLHE40 (basic helix-loop-helix family member e40).
Genome Resources: Alliance (1),  Gene:324413 (1),  Ensembl(GRCz11):ENSDARG00000004060 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16419 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21951 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35135 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38854 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bhlhe40 N/A 1
    MO2-bhlhe40 N/A 1
    PHENOTYPE
    Data: Fig. 4 from Ben-Moshe et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH bhlhe40 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH bhlhe40 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process circadian regulation of gene expression (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003650 Orange domain
    Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bhlhe40-201 (1)    Ensembl 2804
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bhlhe40 No data available
    MARKER RELATIONSHIPS
    bhlhe40 Contained in: [BAC] DKEYP-81F11 (1)
    bhlhe40 Encodes: [EST] fc28a06, fm54h07 (1)
    [cDNA] MGC:76913 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212679 (1) 2743 bp
    Genomic GenBank:BX914197 (1) 198600 bp
    Select Tool
    Polypeptide UniProtKB:Q0D311 (1) 403 aa
    Sequence Information (all 17)
    ORTHOLOGY for bhlhe40 ( Chr: 11 )
    CITATIONS (45)