Gene
ppargc1b
- ID
- ZDB-GENE-030616-43
- Name
- peroxisome proliferator-activated receptor gamma, coactivator 1 beta
- Symbol
- ppargc1b Nomenclature History
- Previous Names
-
- perc1b (1)
- fb55c08
- sb:cb520
- si:bz1d10.4
- wu:fb55c08
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable transcription coactivator activity. Predicted to be involved in energy homeostasis and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; cranial ganglion; immature eye; male organism; and retina. Human ortholog(s) of this gene implicated in obesity. Orthologous to human PPARGC1B (PPARG coactivator 1 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb520 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Northam et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleotide-binding alpha-beta plait domain superfamily | PGC-1 | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AP47 | InterPro | 848 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ppargc1b-201
(1)
|
Ensembl | 7,020 nt | ||
| mRNA |
ppargc1b-202
(1)
|
Ensembl | 2,752 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-93N22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-282E7 | ZFIN Curated Data | |
| Contained in | BAC | RP71-1D10 | ZFIN Curated Data | |
| Encodes | EST | cb520 | ||
| Encodes | EST | fb55c08 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009291061 (1) | 2968 nt | ||
| Genomic | GenBank:CU074314 (1) | 170905 nt | ||
| Polypeptide | UniProtKB:A0A8M3AP47 (1) | 848 aa |
- Kurchaba, N., Charette, J.M., LeMoine, C.M.R. (2022) Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscle. American journal of physiology. Regulatory, integrative and comparative physiology. 323(3):R319-R330
- Ruggiero, G., Ben-Moshe Livne, Z., Wexler, Y., Geyer, N., Vallone, D., Gothilf, Y., Foulkes, N.S. (2021) Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions. Frontiers in molecular neuroscience. 14:718387
- Giarmarco, M.M., Brock, D.C., Robbings, B.M., Cleghorn, W.M., Tsantilas, K.A., Kuch, K.C., Ge, W., Rutter, K.M., Parker, E.D., Hurley, J.B., Brockerhoff, S.E. (2020) Daily mitochondrial dynamics in cone photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. 117:28816-28827
- Collins, M.M., Ahlberg, G., Hansen, C.V., Guenther, S., Marín-Juez, R., Sokol, A.M., El-Sammak, H., Piesker, J., Hellsten, Y., Olesen, M.S., Stainier, D.Y.R., Lundegaard, P.R. (2019) Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model. Proceedings of the National Academy of Sciences of the United States of America. 116(48):24115-24121
- Northam, C., LeMoine, C.M.R. (2019) Metabolic regulation by the PGC-1α and PGC-1β coactivators in larval zebrafish (Danio rerio). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 234:60-67
- Wu, Y., Su, G., Tang, S., Liu, W., Ma, Z., Zheng, X., Liu, H., Yu, H. (2017) The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. Chemosphere. 168:122-130
- Masuda, T., Wada, Y., Kawamura, S. (2016) ES1 is a mitochondrial enlarging factor contributing to form mega-mitochondria in zebrafish cones. Scientific Reports. 6:22360
- Arslan-Ergul, A., and Adams, M.M. (2014) Gene expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic. BMC Neuroscience. 15:29
- Gu, Q., Yang, X., Lin, L., Li, S., Li, Q., Zhong, S., Peng, J., Cui, Z. (2014) Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. Hepatology (Baltimore, Md.). 60(6):1929-41
- Li, Y., Li, G., Wang, H., Du, J., and Yan, J. (2013) Analysis of a gene regulatory cascade mediating circadian rhythm in zebrafish. PLoS Computational Biology. 9(2):e1002940
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