Gene

smad1

ID
ZDB-GENE-991119-8
Name
SMAD family member 1
Symbol
smad1 Nomenclature History
Previous Names
  • madh1
  • fb39h09
  • sb:eu786
  • SMA- and MAD-related protein 1
  • wu:fb39h09 (1)
  • wu:fb97e04
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have DNA binding activity; DNA-binding transcription factor activity; and metal ion binding activity. Involved in several processes, including BMP signaling pathway; myeloid cell development; and negative regulation of transcription, DNA-templated. Predicted to localize to cytoplasm; nucleus; and transcription regulator complex. Is expressed in several structures, including fin; immature eye; mesoderm; nervous system; and optic primordium. Orthologous to human SMAD1 (SMAD family member 1).
Genome Resources
Note
None
Expression
All Expression Data
31 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smad1 Human Ortholog
No data available
Associated With smad1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001132 SMAD domain, Dwarfin-type
Domain IPR003619 MAD homology 1, Dwarfin-type
Domain IPR013019 MAD homology, MH1
Family IPR013790 Dwarfin
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR017855 SMAD-like domain superfamily
Homologous_superfamily IPR036578 SMAD MH1 domain superfamily
Domain Details Per Protein
Protein Length Dwarfin MAD homology 1, Dwarfin-type MAD homology, MH1 SMAD domain, Dwarfin-type SMAD/FHA domain superfamily SMAD-like domain superfamily SMAD MH1 domain superfamily
UniProtKB:Q5PQZ2 472
UniProtKB:Q7T082 473
UniProtKB:Q9I8V2 472
UniProtKB:A0A2R8QNV3 340
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-smad polyclonal IgG Rabbit
  • IHC
  • WB
Cell Signaling Technology, Inc.
70
Ab1-smad1 polyclonal IgG Rabbit
  • WB
Abcam plc
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations