ZFIN

ZFIN ID: ZDB-GENE-990415-208

ZFIN ID: ZDB-GENE-990415-208

CITATIONS (80 total)

Gene Name:	platelet-derived growth factor receptor, alpha polypeptide
Gene Symbol:	pdgfra

Mao, A., Li, Z., Ning, G., Zhou, Z., Wei, C., Li, J., He, X., Wang, Q. (2023) Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis. Development (Cambridge, England). 150(22):

Murayama, E., Vivier, C., Schmidt, A., Herbomel, P. (2023) Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis. Nature communications. 14:11711171

Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):

Hariom, S.K., Nelson, E.J.R. (2022) Effects of short-term hypergravity on hematopoiesis and vasculogenesis in embryonic zebrafish. Life sciences in space research. 34:21-29

Leonard, E.V., Figueroa, R.J., Bussmann, J., Lawson, N.D., Amigo, J.D., Siekmann, A.F. (2022) Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing ones and differentially require pdgfrb signalling for their development. Development (Cambridge, England). 149(7)

Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:

Xia, Y., Duca, S., Perder, B., Dündar, F., Zumbo, P., Qiu, M., Yao, J., Cao, Y., Harrison, M.R.M., Zangi, L., Betel, D., Cao, J. (2022) Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration. Nature communications. 13:77047704

Yu, Y., Alvarado, R., Petty, L.E., Bohlender, R.J., Shaw, D.M., Below, J.E., Bejar, N., Ruiz, O.E., Tandon, B., Eisenhoffer, G.T., Kiss, D.L., Huff, C.D., Letra, A., Hecht, J.T. (2022) Polygenic risk impacts PDGFRA mutation penetrance in nonsyndromic cleft lip and palate. Human molecular genetics. 31(14):2348-2357

Ando, K., Shih, Y.H., Ebarasi, L., Grosse, A., Portman, D., Chiba, A., Mattonet, K., Gerri, C., Stainier, D.Y.R., Mochizuki, N., Fukuhara, S., Betsholtz, C., Lawson, N.D. (2021) Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development. Developmental Biology. 479:11-22

Kramer, A., Astuti, Y., Elfstrum, A., Lehrke, M.J., Tolar, J., Blazar, B.R., Blake, A., Taisto, M., Furcich, J.W., Nolan, E.E., Durose, W.W., Webber, B.R., Geisness, A., Wood, D.K., Lund, T. (2021) An irradiated marrow niche reveals a small non-collagenous protein mediator of homing, dermatopontin. Blood advances. 5(18):3609-3622

Swartz, M.E., Lovely, C.B., Eberhart, J.K. (2021) Variation in phenotypes from a Bmp-Gata3 genetic pathway is modulated by Shh signaling. PLoS Genetics. 17:e1009579

Caetano-Lopes, J., Henke, K., Urso, K., Duryea, J., Charles, J.F., Warman, M.L., Harris, M.P. (2020) Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish. Development (Cambridge, England). 147(2):

Lefkopoulos, S., Polyzou, A., Derecka, M., Bergo, V., Clapes, T., Cauchy, P., Jerez-Longres, C., Onishi-Seebacher, M., Yin, N., Martagon-Calderón, N.A., Potts, K.S., Klaeylé, L., Liu, F., Bowman, T.V., Jenuwein, T., Mione, M.C., Trompouki, E. (2020) Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells. Immunity. 53:934-951.e9

Luo, J., Liu, P., Lu, C., Bian, W., Su, D., Zhu, C., Xie, S., Pan, Y., Li, N., Cui, W., Pei, D.S., Yang, X. (2020) Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish. Brain : a journal of neurology. 144(2):615-635

Lv, H., Liu, B., Qin, Y. (2020) Isosorbide mononitrate promotes angiogenesis in embryonic development of zebrafish. Genetics and Molecular Biology. 43:20190233

Wang, G., Muhl, L., Padberg, Y., Dupont, L., Peterson-Maduro, J., Stehling, M., le Noble, F., Colige, A., Betsholtz, C., Schulte-Merker, S., van Impel, A. (2020) Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis. Nature communications. 11:2724

D'Agati, G., Cabello, E.M., Frontzek, K., Rushing, E.J., Klemm, R., Robinson, M.D., White, R.M., Mosimann, C., Burger, A. (2019) Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish. Disease models & mechanisms. 12(7):

Lowe, V., Wisniewski, L., Sayers, J., Evans, I., Frankel, P., Mercader-Huber, N., Zachary, I.C., Pellet-Many, C. (2019) Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart. Development (Cambridge, England). 146(13):

Mullapudi, S.T., Boezio, G.L.M., Rossi, A., Marass, M., Matsuoka, R.L., Matsuda, H., Helker, C.S.M., Yang, Y.H.C., Stainier, D.Y.R. (2019) Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function. Development (Cambridge, England). 146(21):

Umali, J., Hawkey-Noble, A., French, C.R. (2019) Loss of foxc1 in zebrafish reduces optic nerve size and cell number in the ganglion cell layer. Vision Research. 156:66-72

Espina, J., Marchant, C., De Ferrari, G.V., Reyes, A.E. (2018) Pdgf1aa regulates zebrafish neural crest cells migration through Hif-1 in an oxygen-independent manner. Mechanisms of Development. 154:203-207

Pinto, R.A., Almeida-Santos, J., Lourenço, R., Saúde, L. (2018) Identification of Dmrt2a downstream genes during zebrafish early development using a timely controlled approach. BMC Developmental Biology. 18:14

Bloomekatz, J., Singh, R., Prall, O.W., Dunn, A.C., Vaughan, M., Loo, C.S., Harvey, R.P., Yelon, D. (2017) Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly. eLIFE. 6

Damm, E.W., Clements, W.K. (2017) Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche. Nature cell biology. 19(5):457-467

El-Rass, S., Eisa-Beygi, S., Khong, E., Brand-Arzamendi, K., Mauro, A., Zhang, H., Clark, K.J., Ekker, S.C., Wen, X.Y. (2017) Disruption of pdgfra alters endocardial and myocardial fusion during zebrafish cardiac assembly.. Biology Open. 6(3):348-357

Lee, S.L.J., Horsfield, J.A., Black, M.A., Rutherford, K., Fisher, A., Gemmell, N.J. (2017) Histological and transcriptomic effects of 17α-methyltestosterone on zebrafish gonad development. BMC Genomics. 18:557

Lim, S.E., Esain, V., Kwan, W., Theodore, L.N., Cortes, M., Frost, I.M., Liu, S.Y., North, T.E. (2017) HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation. Experimental hematology. 46:83-95.e6

Schoen, C., Aschrafi, A., Thonissen, M., Poelmans, G., Von den Hoff, J.W., Carels, C.E.L. (2017) MicroRNAs in Palatogenesis and Cleft Palate. Frontiers in Physiology. 8:165

McCarthy, N., Liu, J.S., Richarte, A.M., Eskiocak, B., Lovely, C.B., Tallquist, M.D., Eberhart, J.K. (2016) Pdgfra and Pdgfrb genetically interact during craniofacial development. Developmental Dynamics : an official publication of the American Association of Anatomists. 245(6):641-52

Marchegiani, S., Davis, T., Tessadori, F., van Haaften, G., Brancati, F., Hoischen, A., Huang, H., Valkanas, E., Pusey, B., Schanze, D., Venselaar, H., Vulto-van Silfhout, A.T., Wolfe, L.A., Tifft, C.J., Zerfas, P.M., Zambruno, G., Kariminejad, A., Sabbagh-Kermani, F., Lee, J., Tsokos, M.G., Lee, C.R., Ferraz, V., da Silva, E.M., Stevens, C.A., Roche, N., Bartsch, O., Farndon, P., Bermejo-Sanchez, E., Brooks, B.P., Maduro, V., Dallapiccola, B., Ramos, F.J., Chung, H.B., Le Caignec, C., Martins, F., Jacyk, W.K., Mazzanti, L., Brunner, H.G., Bakkers, J., Lin, S., Malicdan, M.C., Boerkoel, C.F., Gahl, W.A., de Vries, B.B., van Haelst, M.M., Zenker, M., Markello, T.C. (2015) Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes. American journal of human genetics. 97(1):99-110

Blüthgen, N., Meili, N., Chew, G., Odermatt, A., and Fent, K. (2014) Accumulation and effects of the UV-filter octocrylene in adult and embryonic zebrafish (Danio rerio). The Science of the total environment. 476-477:207-217

French, C.R., Seshadri, S., Destefano, A.L., Fornage, M., Arnold, C.R., Gage, P.J., Skarie, J.M., Dobyns, W.B., Millen, K.J., Liu, T., Dietz, W., Kume, T., Hofker, M., Emery, D.J., Childs, S.J., Waskiewicz, A.J., Lehmann, O.J. (2014) Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. J. Clin. Invest.. 124(11):4877-81

Kartopawiro, J., Bower, N.I., Karnezis, T., Kazenwadel, J., Betterman, K.L., Lesieur, E., Koltowska, K., Astin, J., Crosier, P., Vermeren, S., Achen, M.G., Stacker, S.A., Smith, K.A., Harvey, N.L., François, M., and Hogan, B.M. (2014) Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human molecular genetics. 23(5):1286-97

McGurk, P.D., Lovely, C.B., and Eberhart, J.K. (2014) Analyzing craniofacial morphogenesis in zebrafish using 4D confocal microscopy. Journal of visualized experiments : JoVE. (83):e51190

McCarthy, N., Wetherill, L., Lovely, C.B., Swartz, M.E., Foroud, T.M., and Eberhart, J.K. (2013) Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. Development (Cambridge, England). 140(15):3254-3265

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Delaurier, A., Nakamura, Y., Braasch, I., Khanna, V., Kato, H., Wakitani, S., Postlethwait, J.H., and Kimmel, C.B. (2012) Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton. BMC Developmental Biology. 12(1):16

Charoensawan, V., Adryan, B., Martin, S., Söllner, C., Thisse, B., Thisse, C., Wright, G.J., and Teichmann, S.A. (2010) The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways. Molecular & cellular proteomics : MCP. 9(12):2666-2677

Kim, J., Wu, Q., Zhang, Y., Wiens, K.M., Huang, Y., Rubin, N., Shimada, H., Handin, R.I., Chao, M.Y., Tuan, T.L., Starnes, V.A., and Lien, C.L. (2010) PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts. Proceedings of the National Academy of Sciences of the United States of America. 107(40):17206-17210

Martin, S., Söllner, C., Charoensawan, V., Adryan, B., Thisse, B., Thisse, C., Teichmann, S.A., and Wright, G.J. (2010) Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Molecular & cellular proteomics : MCP. 9(12):2654-2665

Eberhart, J.K., He, X., Swartz, M.E., Yan, Y.L., Song, H., Boling, T.C., Kunerth, A.K., Walker, M.B., Kimmel, C.B., and Postlethwait, J.H. (2008) MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nature Genetics. 40(3):290-298

Swindell, E.C., Zilinski, C.A., Hashimoto, R., Shah, R., Lane, M.E., and Jamrich, M. (2008) Regulation and function of foxe3 during early zebrafish development. Genesis (New York, N.Y. : 2000). 46(3):177-183

Siegel, N., Hoegg, S., Salzburger, W., Braasch, I., and Meyer, A. (2007) Comparative genomics of ParaHox clusters of teleost fishes: gene cluster breakup and the retention of gene sets following whole genome duplications. BMC Genomics. 8:312

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Braasch, I., Salzburger, W., and Meyer, A. (2006) Asymmetric evolution in two fish-specifically duplicated receptor tyrosine kinase paralogons involved in teleost coloration. Mol. Biol. Evol.. 23(6):1192-1202

Lien, C.L., Schebesta, M., Makino, S., Weber, G.J., and Keating, M.T. (2006) Gene Expression Analysis of Zebrafish Heart Regeneration. PLoS Biology. 4(8):e260

Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314

Zhang, C., Willett, C., and Fremgen, T. (2003) Zebrafish: An animal model for toxicological studies. Current Protocols in Toxicology. Unit 1.7

Liu, L., Chong, S.W., Balasubramaniyan, N.V., Korzh, V., and Ge, R. (2002) Platelet-derived growth factor receptor alpha (pdgfr-alpha) gene in zebrafish embryonic development. Mechanisms of Development. 116(1-2):227-230

Williams, H., Brenner, S., and Venkatesh, B. (2002) Identification and analysis of additional copies of the platelet-derived growth factor receptor and colony stimulating factor 1 receptor genes in fugu. Gene. 295(2):255-264

Gates, M.A., Kim, L., Egan, E.S., Cardozo, T., Sirotkin, H.I., Dougan, S.T., Lashkari, D., Abagyan, R., Schier, A.F., and Talbot, W.S. (1999) A genetic linkage map for zebrafish: comparative analysis and localization of genes and expressed sequences. Genome research. 9(4):334-347

Additional Citations (29):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Automatic Gene Ontology annotation based on Rhea mapping. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. Manually curated data.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

Thisse, B., Wright, G.J., Thisse, C. (2008) Embryonic and Larval Expression Patterns from a Large Scale Screening for Novel Low Affinity Extracellular Protein Interactions. ZFIN Direct Data Submission.

ZIRC and ZFIN Staff (2008) Mutant and Transgenic Line Submissions 2008. ZFIN Direct Data Submission.

Bushell, K.M., Söllner, C., Schuster-Boeckler, B., Bateman, A., Wright, G.J., (2007) Submission of Data From a Large Scale Screening for Novel Low Affinity Extracellular Protein Interactions. ZFIN Direct Data Submission.

GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.

GOA, HGNC, AgBase and UniProtKB curators (2007) Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity. ZFIN Direct Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of FPC Database Links. Automated Data Submission.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of EMBL records. Automated Data Submission.