ZFIN

ZFIN ID: ZDB-GENE-090128-3

ZFIN ID: ZDB-GENE-090128-3

CITATIONS (60 total)

Gene Name:	gonadotropin releasing hormone receptor 2
Gene Symbol:	gnrhr2

Zhang, F., Tang, C., Wang, J., Lin, T., Ge, W., He, C., Yang, C., Zuo, Z. (2024) Letrozole induced a polycystic ovary syndrome model in zebrafish by interfering with the hypothalamic-pituitary-gonadal axis. Environmental pollution (Barking, Essex : 1987). 347:123723

Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201

Duan, M., Guo, X., Chen, X., Guo, M., Xu, H., Hao, L., Wang, C., Yang, Y. (2022) Life Cycle Exposure to Cyhalofop-Butyl Induced Reproductive Toxicity in Zebrafish. Toxics. 10(9)

Tsakoumis, E., Ahi, E.P., Schmitz, M. (2022) Impaired leptin signaling causes subfertility in female zebrafish. Molecular and Cellular Endocrinology. 546:111595

Bao, M., Zheng, S., Liu, C., Huang, W., Xiao, J., Wu, K. (2020) Perfluorooctane sulfonate exposure alters sexual behaviors and transcriptions of genes in hypothalamic-pituitary-gonadal-liver axis of male zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 267:115585

Bhuiyan, M.N.H., Kang, H., Choi, J., Lim, S., Kho, Y., Choi, K. (2020) Effects of 3,4-dichloroaniline (3,4-DCA) and 4,4'-methylenedianiline (4,4'-MDA) on sex hormone regulation and reproduction of adult zebrafish (Danio rerio). Chemosphere. 269:128768

Fallah, H.P., Rodrigues, M.S., Corchuelo, S., Nóbrega, R.H., Habibi, H.R. (2020) Role of GnRH isoforms in paracrine/autocrine control of zebrafish (Danio rerio) spermatogenesis. Endocrinology. 161(2):

Mitchell, K., Zhang, W.S., Lu, C., Tao, B., Chen, L., Hu, W., Trudeau, V.L. (2020) Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 117(23):12772-12783

Teng, M., Wang, C., Song, M., Chen, X., Zhang, J., Wang, C. (2020) Chronic exposure of zebrafish (Danio rerio) to flutolanil leads to endocrine disruption and reproductive disorders. Environmental research. 184:109310

Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166

Cao, J., Wang, G., Wang, T., Chen, J., Wenjing, G., Wu, P., He, X., Xie, L. (2019) Copper caused reproductive endocrine disruption in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 211:124-136

Kawan, A., Zhang, T., Liu, W., Mukhtar, H., Zhan, C., Zhang, X. (2019) Recovery of reproductive function of female zebrafish from the toxic effects of microcystin-LR exposure. Aquatic toxicology (Amsterdam, Netherlands). 214:105240

Paredes, J.F., Cowan, M., López-Olmeda, J.F., Muñoz-Cueto, J.A., Sánchez-Vázquez, F.J. (2019) Daily rhythms of expression in reproductive genes along the brain-pituitary-gonad axis and liver of zebrafish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 231:158-169

Teng, M., Chen, X., Wang, C., Song, M., Zhang, J., Bi, S., Wang, C. (2019) Life cycle exposure to propiconazole reduces fecundity by disrupting the steroidogenic pathway and altering DNA methylation in zebrafish (Danio rerio). Environment International. 135:105384

Wu, X.J., Jermaul Williams, M., Rameshkumar Patel, P., Ann Kew, K., Zhu, Y. (2019) Subfertility and reduced progestin synthesis in Pgrmc2 knockout zebrafish. General and comparative endocrinology. 282:113218

Xie, X., Jin, Y., Ma, Z., Tang, S., Peng, H., Giesy, J.P., Liu, H. (2019) Underlying mechanisms of reproductive toxicity caused by multigenerational exposure of 2, bromo-4, 6-dinitroaniline (BDNA) to Zebrafish (Danio rerio) at environmental relevant levels. Aquatic toxicology (Amsterdam, Netherlands). 216:105285

Jiang, J., Lv, L., Wu, S., An, X., Wang, F., Liu, X., Zhao, X. (2018) Developmental toxicity of kresoxim-methyl during zebrafish (Danio rerio) larval development. Chemosphere. 219:517-525

Jiang, J., Shi, Y., Yu, R., Chen, L., Zhao, X. (2018) Biological response of zebrafish after short-term exposure to azoxystrobin. Chemosphere. 202:56-64

Lee, J., Park, N.Y., Kho, Y., Ji, K. (2018) Effects of 4-Hydroxyphenyl 4-Isoprooxyphenylsulfone (BPSIP) Exposure on Reproduction and Endocrine System of Zebrafish. Environmental science & technology. 52(3):1506-1513

Wang, Y., Dai, D., Yu, Y., Yang, G., Shen, W., Wang, Q., Weng, H., Zhao, X. (2018) Evaluation of joint effects of cyprodinil and kresoxim-methyl on zebrafish, Danio rerio. Journal of hazardous materials. 352:80-91

Corchuelo, S., Martinez, E.R., Butzge, A.J., Doretto, L.B., Valentin, T.N., Nakaghi, L.S., Somoza, G.M., Nóbrega, R.H. (2017) Characterization of Gnrh/Gnih elements in the olfacto-retinal system and ovary during zebrafish ovarian maturation. Molecular and Cellular Endocrinology. 450:1-13

Liu, G., Ke, M., Fan, X., Zhang, M., Zhu, Y., Lu, T., Sun, L., Qian, H. (2017) Reproductive and endocrine-disrupting toxicity of Microcystis aeruginosa in female zebrafish. Chemosphere. 192:289-296

Teng, M., Qi, S., Zhu, W., Wang, Y., Wang, D., Dong, K., Wang, C. (2017) Effects of the bioconcentration and parental transfer of environmentally relevant concentrations of difenoconazole on endocrine disruption in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 233:208-217

Xu, Q., Wu, D., Dang, Y., Yu, L., Liu, C., Wang, J. (2017) Reproduction impairment and endocrine disruption in adult zebrafish (Danio rerio) after waterborne exposure to TBOEP. Aquatic toxicology (Amsterdam, Netherlands). 182:163-171

Yang, Q., Yang, X., Liu, J., Ren, W., Chen, Y., Shen, S. (2017) Effects of BPF on steroid hormone homeostasis and gene expression in the hypothalamic-pituitary-gonadal axis of zebrafish. Environmental science and pollution research international. 24(26):21311-21322

Yu, M., Feng, Y., Zhang, X., Wang, J., Tian, H., Wang, W., Ru, S. (2017) Semicarbazide disturbs the reproductive system of male zebrafish (Danio rerio) through the GABAergic system. Reproductive toxicology (Elmsford, N.Y.). 73:149-157

Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37

Dang, Y., Wang, J., Giesy, J.P., Liu, C. (2016) Responses of the zebrafish hypothalamic-pituitary-gonadal-liver axis PCR array to prochloraz are dependent on timing of sampling. Aquatic toxicology (Amsterdam, Netherlands). 175:154-159

Khor, Y.M., Soga, T., Parhar, I.S. (2016) Early-Life Stress Changes Expression of GnRH and Kisspeptin Genes and DNA Methylation of GnRH3 Promoter in The Adult Zebrafish Brain. General and comparative endocrinology. 227:84-93

Kwon, B., Ha, N., Jung, J., Kim, P.G., Kho, Y., Choi, K., Ji, K. (2016) Effects of Barium Chloride Exposure on Hormones and Genes of the Hypothalamic-Pituitary-Gonad Axis, and Reproduction of Zebrafish (Danio rerio). Bulletin of environmental contamination and toxicology. 96(3):341-6

Kwon, B., Shin, H., Moon, H.B., Ji, K., Kim, K.T. (2016) Effects of tris(2-butoxyethyl) phosphate exposure on endocrine systems and reproduction of zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 214:568-574

Liu, W., Chen, C., Chen, L., Wang, L., Li, J., Chen, Y., Jin, J., Kawan, A., Zhang, X. (2016) Sex-dependent effects of microcystin-LR on hypothalamic-pituitary-gonad axis and gametogenesis of adult zebrafish. Scientific Reports. 6:22819

Liu, X., Jung, D., Jo, A., Ji, K., Moon, H.B., Choi, K. (2016) Long-term exposure to triphenyl phosphate alters hormone balance and HPG, HPI, and HPT gene expression in zebrafish (Danio rerio). Environmental toxicology and chemistry. 35(9):2288-96

Ma, Z., Tang, S., Su, G., Miao, Y., Liu, H., Xie, Y., Giesy, J.P., Saunders, D.M., Hecker, M., Yu, H. (2016) Effects of tris (2-butoxyethyl) phosphate (TBOEP) on endocrine axes during development of early life stages of zebrafish (Danio rerio). Chemosphere. 144:1920-1927

Muth-Köhne, E., Westphal-Settele, K., Brückner, J., Konradi, S., Schiller, V., Schäfers, C., Teigeler, M., Fenske, M. (2016) Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test. Aquatic toxicology (Amsterdam, Netherlands). 176:116-127

Yu, M., Zhang, X., Guo, L., Tian, H., Wang, W., Ru, S. (2016) Anti-estrogenic effect of semicarbazide in female zebrafish (Danio rerio) and its potential mechanisms. Aquatic toxicology (Amsterdam, Netherlands). 170:262-270

Cortés-Campos, C., Letelier, J., Ceriani, R., Whitlock, K.E. (2015) Zebrafish adult-derived hypothalamic neurospheres generate gonadotropin-releasing hormone (GnRH) neurons. Biology Open. 4(9):1077-86

Tzung, K.W., Goto, R., Saju, J.M., Sreenivasan, R., Saito, T., Arai, K., Yamaha, E., Hossain, M.S., Calvert, M.E., Orbán, L. (2015) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Reports. 4(1):61-73

Zhao, Y., Xie, L., Yan, Y. (2015) Microcystin-LR impairs zebrafish reproduction by affecting oogenesis and endocrine system. Chemosphere. 120C:115-122

Jo, A., Ji, K., Choi, K. (2014) Endocrine disruption effects of long-term exposure to perfluorodecanoic acid (PFDA) and perfluorotridecanoic acid (PFTrDA) in zebrafish (Danio rerio) and related mechanisms. Chemosphere. 108:360-6

Ji, K., Hong, S., Kho, Y., and Choi, K. (2013) Effects of bisphenol S exposure on endocrine functions and reproduction of zebrafish. Environmental science & technology. 47(15):8793-800

Ji, K., Liu, X., Lee, S., Kang, S., Kho, Y., Giesy, J.P., and Choi, K. (2013) Effects of non-steroidal anti-inflammatory drugs on hormones and genes of the hypothalamic-pituitary-gonad axis, and reproduction of zebrafish. Journal of hazardous materials. 254-255C:242-251

Jung Collard, H.R., Ji, K., Lee, S., Liu, X., Kang, S., Kho, Y., Ahn, B., Ryu, J., Lee, J., and Choi, K. (2013) Toxicity and endocrine disruption in zebrafish (Danio rerio) and two freshwater invertebrates (Daphnia magna and Moina macrocopa) after chronic exposure to mefenamic acid. Ecotoxicology and environmental safety. 94:80-86

Liu, C., Zhang, X., Deng, J., Hecker, M., Al-Khedhairy, A., Giesy, J.P., and Zhou, B. (2011) Effects of Prochloraz or Propylthiouracil on the Cross-Talk between the HPG, HPA, and HPT Axes in Zebrafish. Environmental science & technology. 45(2):769-775

Tello, J.A., Wu, S., Rivier, J.E., and Sherwood, N.M. (2008) Four functional GnRH receptors in zebrafish: Analysis of structure, signaling, synteny and phylogeny. Integrative and Comparative Biology. 48(5):570-587

Flanagan, C.A., Chen, C.C., Coetsee, M., Mamputha, S., Whitlock, K.E., Bredenkamp, N., Grosenick, L., Fernald, R.D., and Illing, N. (2007) Expression, structure, function, and evolution of gonadotropin-releasing hormone (GnRH) receptors GnRH-R1SHS and GnRH-R2PEY in the teleost, Astatotilapia burtoni. Endocrinology. 148(10):5060-5071

Lethimonier, C., Madigou, T., Munoz-Cueto, J.A., Lareyre, J.J., and Kah, O. (2004) Evolutionary aspects of GnRHs, GnRH neuronal systems and GnRH receptors in teleost fish. General and comparative endocrinology. 135(1):1-16

Additional Citations (13):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.