PUBLICATION
Effects of 4-Hydroxyphenyl 4-Isoprooxyphenylsulfone (BPSIP) Exposure on Reproduction and Endocrine System of Zebrafish
- Authors
- Lee, J., Park, N.Y., Kho, Y., Ji, K.
- ID
- ZDB-PUB-180127-6
- Date
- 2018
- Source
- Environmental science & technology 52(3): 1506-1513 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Endocrine Disruptors*
- Endocrine System
- Female
- Gonads
- Humans
- Male
- Reproduction
- Vitellogenins
- Water Pollutants, Chemical*
- Zebrafish
- PubMed
- 29373025 Full text @ Env. Sci. Tech.
Citation
Lee, J., Park, N.Y., Kho, Y., Ji, K. (2018) Effects of 4-Hydroxyphenyl 4-Isoprooxyphenylsulfone (BPSIP) Exposure on Reproduction and Endocrine System of Zebrafish. Environmental science & technology. 52(3):1506-1513.
Abstract
The compound 4-hydroxyphenyl 4-isoprooxyphenylsulfone (BPSIP), a derivative of bisphenol S (BPS), has been detected in thermal paper and human urine samples; however, its potential effects on the endocrine system are largely unknown. The present study was conducted to determine the adverse effects of BPSIP on egg production, relative organ weights, plasma levels of sex hormones, and transcription of genes related to the hypothalamus-pituitary-gonad (HPG) axis in zebrafish (Danio rerio). In male fish, the gonadosomatic index was significantly decreased at concentrations of 5 and 50 μg/L BPSIP. The estrogenic (increase in the 17β-estradiol/testosterone [E2/T] ratio) and antiandrogenic (decrease in T) effects were observed in fish exposed to BPSIP and males were more sensitive to the adverse effects than females. The changes in sex hormones were supported by the regulation of genes along the HPG axis, such as cyp19, 17βhsd, and cyp17 transcripts. Although the effective concentration for endocrine disruption was greater than that of BPS, the actions of BPSIP on the steroidogenic pathway were similar to the effects of BPS exposure.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping