PUBLICATION
Effects of Barium Chloride Exposure on Hormones and Genes of the Hypothalamic-Pituitary-Gonad Axis, and Reproduction of Zebrafish (Danio rerio)
- Authors
- Kwon, B., Ha, N., Jung, J., Kim, P.G., Kho, Y., Choi, K., Ji, K.
- ID
- ZDB-PUB-160114-7
- Date
- 2016
- Source
- Bulletin of environmental contamination and toxicology 96(3): 341-6 (Journal)
- Registered Authors
- Choi, Kyungho
- Keywords
- Barium chloride, Endocrine disruption, HPG axis, Reproduction, Zebrafish
- MeSH Terms
-
- Animals
- Aromatase/genetics
- Barium Compounds/toxicity*
- Chlorides/toxicity*
- Dose-Response Relationship, Drug
- Endocrine Disruptors/toxicity*
- Female
- Gonadal Steroid Hormones/metabolism*
- Gonads/drug effects*
- Gonads/metabolism
- Hypothalamo-Hypophyseal System/drug effects*
- Hypothalamo-Hypophyseal System/metabolism
- Male
- Reproduction/drug effects*
- Sex Factors
- Transcription, Genetic/drug effects
- Zebrafish*/genetics
- Zebrafish*/metabolism
- Zebrafish Proteins/genetics
- PubMed
- 26758458 Full text @ Bull. Environ. Contam. Toxicol.
Citation
Kwon, B., Ha, N., Jung, J., Kim, P.G., Kho, Y., Choi, K., Ji, K. (2016) Effects of Barium Chloride Exposure on Hormones and Genes of the Hypothalamic-Pituitary-Gonad Axis, and Reproduction of Zebrafish (Danio rerio). Bulletin of environmental contamination and toxicology. 96(3):341-6.
Abstract
Adult zebrafish pairs were exposed to sub-lethal concentrations of BaCl2 for 21 days, and the effects on reproduction, sex steroid hormones, and transcription of the genes belonging to the hypothalamic-pituitary-gonad (HPG) axis were investigated. The adverse effects on performances of F1 generation were further examined with or without subsequent exposure to BaCl2. Egg production was significantly decreased, and parental exposure to BaCl2 resulted in lesser rates of hatching. In males, exposure to BaCl2 resulted in greater concentrations of E2 along with greater mRNA expression of cyp19a. The results demonstrated that BaCl2 could modulate gene transcriptions and hormone production of the HPG axis in a sex-dependent way, which could cause adverse effects on reproduction and the development of offspring.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping