ZFIN ID: ZDB-GENE-080405-1
CITATIONS (83 total)
Gene Name: telomerase reverse transcriptase
Gene Symbol: tert
Campbell, C.A., Calderon, R., Pavani, G., Cheng, X., Barakat, R., Snella, E., Liu, F., Peng, X., Essner, J.J., Dorman, K.S., McGrail, M., Gadue, P., French, D.L., Espin-Palazon, R. (2024) p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation. Nature communications. 15:77877787
Şerifoğlu, N., Lopes-Bastos, B., Ferreira, M.G. (2024) Lack of telomerase reduces cancer incidence and increases lifespan of zebrafish tp53M214K mutants. Scientific Reports. 14:53825382
Amin, A., Morello, M., Petrara, M.R., Rizzo, B., Argenton, F., De Rossi, A., Giunco, S. (2023) Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach. Cancers. 15(10):
El Maï, M., Bird, M., Allouche, A., Targen, S., Şerifoğlu, N., Lopes-Bastos, B., Guigonis, J.M., Kang, D., Pourcher, T., Yue, J.X., Ferreira, M.G. (2023) Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish. Nature aging. 3(5):567-584
Xia, H., Cheng, X., Cao, M., Sun, X., He, F., Yao, X., Liu, H. (2023) Tetrahydroxystilbene Glucoside Attenuates Oxidative Stress-Induced Aging by Regulating Oxidation Resistance and Inflammation in Larval Zebrafish. Zebrafish. 20:556655-66
Ellis, P.S., Martins, R.R., Thompson, E.J., Farhat, A., Renshaw, S.A., Henriques, C.M. (2022) A subset of gut leukocytes has telomerase-dependent "hyper-long" telomeres and require telomerase for function in zebrafish. Immunity & ageing : I & A. 19:31
Hou, C.Y., Ma, C.Y., Lin, Y.J., Huang, C.L., Wang, H.D., Yuh, C.H. (2022) WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy. International Journal of Molecular Sciences. 23(20):
Li, H., Xu, W., Xiang, S., Tao, L., Fu, W., Liu, J., Liu, W., Xiao, Y., Peng, L. (2022) Defining the Pluripotent Marker Genes for Identification of Teleost Fish Cell Pluripotency During Reprogramming. Frontiers in genetics. 13:819682
Martins, R.R., Zamzam, M., Tracey-White, D., Moosajee, M., Thummel, R., Henriques, C.M., MacDonald, R.B. (2022) Müller Glia maintain their regenerative potential despite degeneration in the aged zebrafish retina. Aging Cell. 21(4):e13597
Şerifoğlu, N., Erbaba, B., Adams, M.M., Arslan-Ergül, A. (2022) TERT distal promoter GC islands are critical for telomerase and together with DNMT3B silencing may serve as a senescence-inducing agent in gliomas. Journal of neurogenetics. 36(4):89-97
Espigares, F., Abad-Tortosa, D., Varela, S.A.M., Ferreira, M.G., Oliveira, R.F. (2021) Short telomeres drive pessimistic judgement bias in zebrafish. Biology letters. 17:20200745
Lam, S., Hartmann, N., Benfeitas, R., Zhang, C., Arif, M., Turkez, H., Uhlén, M., Englert, C., Knight, R., Mardinoglu, A. (2021) Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases. Biomedicines. 9(10):
Lee, L., Perez Oliva, A.B., Martinez-Balsalobre, E., Churikov, D., Peter, J., Rahmouni, D., Audoly, G., Azzoni, V., Audebert, S., Camoin, L., Mulero, V., Cayuela, M.L., Kulathu, Y., Geli, V., Lachaud, C. (2021) UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival. Science advances. 7:eabc7371
Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
El Maï, M., Marzullo, M., de Castro, I.P., Ferreira, M.G. (2020) Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish. eLIFE. 9:
Erbaba, B., Burhan, Ö.P., Şerifoğlu, N., Muratoğlu, B., Kahveci, F., Adams, M.M., Arslan-Ergül, A. (2020) Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging. Neurobiology of aging. 94:164-175
Faught, E., Santos, H.B., Vijayan, M.M. (2020) Loss of the glucocorticoid receptor causes accelerated ovarian ageing in zebrafish. Proceedings. Biological sciences. 287:20202190
Giunco, S., Zangrossi, M., Dal Pozzolo, F., Celeghin, A., Ballin, G., Petrara, M.R., Amin, A., Argenton, F., Godinho Ferreira, M., De Rossi, A. (2020) Anti-Proliferative and Pro-Apoptotic Effects of Short-Term Inhibition of Telomerase In Vivo and in Human Malignant B Cells Xenografted in Zebrafish. Cancers. 12(8):
Idilli, A.I., Cusanelli, E., Pagani, F., Berardinelli, F., Bernabé, M., Cayuela, M.L., Poliani, P.L., Mione, M.C. (2020) Expression of tert Prevents ALT in Zebrafish Brain Tumors. Frontiers in cell and developmental biology. 8:65
Idilli, A.I., Pagani, F., Kerschbamer, E., Berardinelli, F., Bernabé, M., Cayuela, M.L., Piazza, S., Poliani, P.L., Cusanelli, E., Mione, M.C. (2020) Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors. Cancers. 12(4)
Idilli, A.I., Pazzi, C., Dal Pozzolo, F., Roccuzzo, M., Mione, M.C. (2020) Rad21 Haploinsufficiency Prevents ALT-Associated Phenotypes in Zebrafish Brain Tumors. Genes. 11(12):
Lex, K., Maia Gil, M., Lopes-Bastos, B., Figueira, M., Marzullo, M., Giannetti, K., Carvalho, T., Ferreira, M.G. (2020) Telomere shortening produces an inflammatory environment that increases tumor incidence in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 117(26):15066-15074
Li, C., Barton, C., Henke, K., Daane, J., Treaster, S., Caetano-Lopez, J., Tanguay, R.L., Harris, M. (2020) Celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. eLIFE. 9:
Wang, X., Giusti, A., Ny, A., de Witte, P.A. (2020) Nephrotoxic Effects in Zebrafish after Prolonged Exposure to Aristolochic Acid. toxins. 12(4):
Zambusi, A., Pelin Burhan, Ö., Di Giaimo, R., Schmid, B., Ninkovic, J. (2020) Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon. Cells. 9(2):
Jia, J., Qin, J., Yuan, X., Liao, Z., Huang, J., Wang, B., Sun, C., Li, W. (2019) Microarray and metabolome analysis of hepatic response to fasting and subsequent refeeding in zebrafish (Danio rerio). BMC Genomics. 20:919
Sun, H., Chen, M., Wang, Z., Zhao, G., Liu, J.X. (2019) Transcriptional profiles and copper stress responses in zebrafish cox17 mutants. Environmental pollution (Barking, Essex : 1987). 256:113364
Hendee, K.E., Sorokina, E.A., Muheisen, S.S., Reis, L.M., Tyler, R.C., Markovic, V., Cuturilo, G., Link, B.A., Semina, E.V. (2018) PITX2 deficiency and associated human disease: insights from the zebrafish model. Human molecular genetics. 27(10):1675-1695
Lin, Y.S., Saputra, F., Chen, Y.C., Hu, S.Y. (2018) Dietary administration of Bacillus amyloliquefaciens R8 reduces hepatic oxidative stress and enhances nutrient metabolism and immunity against Aeromonas hydrophila and Streptococcus agalactiae in zebrafish (Danio rerio). Fish & shellfish immunology. 86:410-419
Scahill, C.M., Digby, Z., Sealy, I.M., White, R.J., Collins, J.E., Busch-Nentwich, E.M. (2017) The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish.. Wellcome open research. 2:77
Carneiro, M.C., Henriques, C.M., Nabais, J., Ferreira, T., Carvalho, T., Ferreira, M.G. (2016) Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish. PLoS Genetics. 12:e1005798
Jayesh, P., Vrinda, S., Priyaja, P., Philip, R., Singh, I.S. (2016) Impaired telomerase activity hinders proliferation and in vitro transformation of Penaeus monodon lymphoid cells. Cytotechnology. 68:1301-14
Bednarek, D., González-Rosa, J.M., Guzmán-Martínez, G., Gutiérrez-Gutiérrez, Ó., Aguado, T., Sánchez-Ferrer, C., Marques, I.J., Galardi-Castilla, M., de Diego, I., Gómez, M.J., Cortés, A., Zapata, A., Jiménez-Borreguero, L.J., Mercader, N., Flores, I. (2015) Telomerase Is Essential for Zebrafish Heart Regeneration. Cell Reports. 12(10):1691-703
Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
Mu, X., Chai, T., Wang, K., Zhang, J., Zhu, L., Li, X., Wang, C. (2015) Occurrence and origin of sensitivity toward difenoconazole in zebrafish (Danio reio) during different life stages. Aquatic toxicology (Amsterdam, Netherlands). 160C:57-68
Alcaraz-Pérez, F., García-Castillo, J., García-Moreno, D., López-Muñoz, A., Anchelin, M., Angosto, D., Zon, L.I., Mulero, V., and Cayuela, M.L. (2014) A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish. Nature communications. 5:3228
Anchelin, M., Alcaraz-Pérez, F., Martínez, C.M., Bernabé-García, M., Mulero, V., and Cayuela, M.L. (2013) Premature aging in telomerase-deficient zebrafish. Disease models & mechanisms. 6(5):1101-12
Fang, X., Corrales, J., Thornton, C., Scheffler, B.E., and Willett, K.L. (2013) Global and gene specific DNA methylation changes during zebrafish development. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 166(1):99-108
Fang, X., Thornton, C., Scheffler, B.E., and Willett, K.L. (2013) Benzo[a]pyrene decreases global and gene specific DNA methylation during zebrafish development. Environmental Toxicology and Pharmacology. 36(1):40-50
Henriques, C.M., Carneiro, M.C., Tenente, I.M., Jacinto, A., and Ferreira, M.G. (2013) Telomerase is required for zebrafish lifespan. PLoS Genetics. 9(1):e1003214
Li, Z., Zheng, W., Wang, Z., Zeng, Z., Zhan, H., Li, C., Zhou, L., Yan, C., Spitsbergen, J.M., and Gong, Z. (2013) A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors. Disease models & mechanisms. 427(1):223-226
Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
Galindo-Villegas, J., García-Moreno, D., de Oliveira, S., Meseguer, J., and Mulero, V. (2012) Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 109(39):E2605-2614
Liu, W., Chen, J.R., Hsu, C.H., Li, Y.H., Chen, Y.M., Lin, C.Y., Huang, S.J., Chang, Z.K., Chen, Y.C., Lin, C.H., Gong, H.Y., Lin, C.C., Kawakami, K., and Wu, J.L. (2012) A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver. Hepatology (Baltimore, Md.). 56(6):2268-2276
Anchelin, M., Murcia, L., Alcaraz-Pérez, F., García-Navarro, E.M., and Cayuela, M.L. (2011) Behaviour of Telomere and Telomerase during Aging and Regeneration in Zebrafish. PLoS One. 6(2):e16955
Robles, V., Martí, M., and Belmonte, J.C. (2011) Study of Pluripotency Markers in Zebrafish Embryos and Transient Embryonic Stem Cell Cultures. Zebrafish. 8(2):57-63
Christen, B., Robles, V., Raya, M., Paramonov, I., and Izpisúa Belmonte, J.C. (2010) Regeneration and reprogramming compared. BMC Biology. 8:5
Lindeman, L.C., Reiner, A.H., Mathavan, S., Aleström, P., and Collas, P. (2010) Tiling histone h3 lysine 4 and 27 methylation in zebrafish using high-density microarrays. PLoS One. 5(12):e15651
Lindeman, L.C., Winata, C.L., Aanes, H., Mathavan, S., Alestrom, P., and Collas, P. (2010) Chromatin states of developmentally-regulated genes revealed by DNA and histone methylation patterns in zebrafish embryos. The International journal of developmental biology. 54(5):803-813
Au, D.W., Mok, H.O., Elmore, L.W., and Holt, S.E. (2009) Japanese medaka: A new vertebrate model for studying telomere and telomerase biology. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 149(2):161-167
Foley, J.E., Yeh, J.R., Maeder, M.L., Reyon, D., Sander, J.D., Peterson, R.T., and Joung, J.K. (2009) Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN). PLoS One. 4(2):e4348
Imamura, S., Uchiyama, J., Koshimizu, E., Hanai, J., Raftopoulou, C., Murphey, R.D., Bayliss, P.E., Imai, Y., Burns, C.E., Masutomi, K., Gagos, S., Zon, L.I., Roberts, T.M., and Kishi, S. (2008) A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One. 3(10):e3364
Lau, B.W., Wong, A.O., Tsao, G.S., So, K.F., and Yip, H.K. (2008) Molecular Cloning and Characterization of the Zebrafish (Danio rerio) Telomerase Catalytic Subunit (Telomerase Reverse Transcriptase, TERT). Journal of molecular neuroscience : MN. 34(1):63-75
Sun, C., Wu, Z., Jia, F., Wang, Y., Li, T., and Zhao, M. (2008) Identification of zebrafish LPTS: A gene with similarities to human LPTS/PinX1 that inhibits telomerase activity. Gene. 420(1):90-98
Xie, M., Mosig, A., Qi, X., Li, Y., Stadler, P.F., and Chen, J.J. (2008) Structure and function of the smallest vertebrate telomerase RNA from teleost fish. The Journal of biological chemistry. 283(4):2049-2059
Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
Additional Citations (26):
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.
Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
ZIRC and ZFIN staff (2013) Mutant and Transgenic Line Submissions 2013. ZFIN Direct Data Submission.
Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.
Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.
UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.
ZIRC and ZFIN staff (2011) Mutant and Transgenic Line Submissions 2011. ZFIN Direct Data Submission.
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
ZIRC and ZFIN staff (2010) Mutant and Transgenic Line Submissions 2010. ZFIN Direct Data Submission.
ZF-MODELS Consortium (2007) ZF-MODELS Consortium and Zebrafish Mutation Resource targeted knock-out mutants. ZFIN Direct Data Submission.
Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.
ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.
ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.
ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
ZFIN Staff (2002) Scientific Curation. Manually curated data.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.
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