Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613

Chen, D.D., Jiang, J.Y., Lu, L.F., Zhang, C., Zhou, X.Y., Li, Z.C., Zhou, Y., Li, S. (2021) Zebrafish Uba1 Degrades IRF3 through K48-Linked Ubiquitination to Inhibit IFN Production. Journal of immunology (Baltimore, Md. : 1950). 207(2):512-522

García-Valtanen, P., Martínez-López, A., López-Muñoz, A., Bello-Perez, M., Medina-Gali, R.M., Ortega-Villaizán, M.D., Varela, M., Figueras, A., Mulero, V., Novoa, B., Estepa, A., Coll, J. (2017) Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes. Frontiers in immunology. 8:121

Hu, Y.W., Zhang, J., Wu, X.M., Cao, L., Nie, P., Chang, M.X. (2018) TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation. Frontiers in immunology. 9:84

Li, C., Zhong, S., Ni, S., Liu, Z., Zhang, S., Ji, G. (2021) Zebrafish Ism1 is a novel antiviral factor that positively regulates antiviral immune responses. Developmental and comparative immunology. 125:104210

Li, S., Lu, L.F., Wang, Z.X., Chen, D.D., Zhang, Y.A. (2016) Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways. Fish & shellfish immunology. 57:262-8

Li, Z., Li, J., Li, Z., Song, Y., Wang, Y., Wang, C., Yuan, L., Xiao, W., Wang, J. (2024) Zebrafish mylipb attenuates antiviral innate immunity through two synergistic mechanisms targeting transcription factor irf3. PLoS pathogens. 20:e1012227e1012227

Lu, L.F., Cui, B.J., Shi, S.C., Wang, Y.Y., Zhang, C., Xu, X., Tian, M.Z., Li, Z.Q., Xu, N., Li, Z.C., Chen, D.D., Zhou, L., Zhai, G., Yin, Z., Li, S. (2026) Male-biased Cyp17a2 orchestrates antiviral sexual dimorphism in fish via STING stabilization and viral protein degradation. eLIFE. 14:

Lu, L.F., Zhou, X.Y., Zhang, C., Li, Z.C., Chen, D.D., Liu, S.B., Li, S. (2019) Zebrafish RPZ5 Degrades the Phosphorylated IRF7 to Repress Interferon Production. Journal of virology. 93(21):

Raas, Q., Haouy, G., de Calbiac, H., Pasho, E., Marian, A., Guerrera, I.C., Rosello, M., Oeckl, P., Del Bene, F., Catanese, A., Ciura, S., Kabashi, E. (2025) TBK1 is involved in programmed cell death and ALS-related pathways in novel zebrafish models. Cell death discovery. 11:9898

Shi, Y., Chen, K., Yan, H., Wang, J., Zou, J., Lu, Y. (2025) Zebrafish ARRDC3a negatively regulates type I IFN production by targeting the RLR signaling pathway. Fish & shellfish immunology. :110430110430

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Sun, F., Zhang, Y.B., Liu, T.K., Shi, J., Wang, B., and Gui, J.F. (2011) Fish MITA Serves as a Mediator for Distinct Fish IFN Gene Activation Dependent on IRF3 or IRF7. Journal of immunology (Baltimore, Md. : 1950). 187(5):2531-9

Wang, Q., Xu, F., Cao, Y., Li, B., Zhang, S., Zhang, Y. (2025) Peptide GTSFTTTAER From Rapana venosa Alleviates TNBS-Induced Inflammatory Bowel Disease in a Zebrafish Model via Multi-Pathway Regulation. Food science & nutrition. 13:e70427e70427

Witteveldt, J., Liu, Z., Ariza-Cosano, A., Ramirez, C., Walters, J.L., Marchante, P.G., Maas, L., Friman, E.T., Ivens, A., Tebaldi, T., Heras, S.R., Marks, H., Macias, S. (2025) Double stranded RNA sensing is silenced during early embryonic development. Nature communications. :

Wu, X.M., Fang, H., Zhang, J., Bi, Y.H., Chang, M.X. (2021) Histone H2A Nuclear/Cytoplasmic Trafficking Is Essential for Negative Regulation of Antiviral Immune Response and Lysosomal Degradation of TBK1 and IRF3. Frontiers in immunology. 12:771277

Yu, G., Li, X., Zhou, Z., Tang, J., Wang, J., Liu, X., Fan, S., Ouyang, G., Xiao, W. (2020) Zebrafish phd3 Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity. Journal of immunology (Baltimore, Md. : 1950). 205(4):1135-1146

Zhang, C., Lu, L.F., Li, Z.C., Han, K.J., Wang, X.L., Chen, D.D., Xiong, F., Li, X.Y., Zhou, L., Ge, F., Li, S. (2023) Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway. Journal of virology. 97(7):e0053223

Zhang, L., Chen, W.Q., Hu, Y.W., Wu, X.M., Nie, P., Chang, M.X. (2016) TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. Fish & shellfish immunology. 54:135-43

Zhong, S., Li, H., Wang, Y.S., Wang, Y., Ji, G., Li, H.Y., Zhang, S., Liu, Z. (2021) Bmp8a is an essential positive regulator of antiviral immunity in zebrafish. Communications biology. 4:318

Lu, L.F., Cui, B.J., Shi, S.C., Wang, Y.Y., Zhang, C., Xu, X., Tian, M.Z., Li, Z.Q., Xu, N., Li, Z.C., Chen, D.D., Zhou, L., Zhai, G., Yin, Z., Li, S. (2026) Male-biased Cyp17a2 orchestrates antiviral sexual dimorphism in fish via STING stabilization and viral protein degradation. eLIFE. 14:

Raas, Q., Haouy, G., de Calbiac, H., Pasho, E., Marian, A., Guerrera, I.C., Rosello, M., Oeckl, P., Del Bene, F., Catanese, A., Ciura, S., Kabashi, E. (2025) TBK1 is involved in programmed cell death and ALS-related pathways in novel zebrafish models. Cell death discovery. 11:9898

Wang, Q., Xu, F., Cao, Y., Li, B., Zhang, S., Zhang, Y. (2025) Peptide GTSFTTTAER From Rapana venosa Alleviates TNBS-Induced Inflammatory Bowel Disease in a Zebrafish Model via Multi-Pathway Regulation. Food science & nutrition. 13:e70427e70427

Witteveldt, J., Liu, Z., Ariza-Cosano, A., Ramirez, C., Walters, J.L., Marchante, P.G., Maas, L., Friman, E.T., Ivens, A., Tebaldi, T., Heras, S.R., Marks, H., Macias, S. (2025) Double stranded RNA sensing is silenced during early embryonic development. Nature communications. :

Qu, Z.L., Gong, X.Y., An, L.L., Sun, H.Y., Guo, W.H., Luan, H.Y., Wu, M.Y., Dan, C., Gui, J.F., Zhang, Y.B. (2024) Genome editing of FTR42 improves zebrafish survival against virus infection by enhancing IFN immunity. iScience. 27:109497109497

Sellaththurai, S., Jung, S., Kim, M.J., Nadarajapillai, K., Ganeshalingam, S., Jeong, J.B., Lee, J. (2023) CRISPR/Cas9-Induced Knockout of Sting Increases Susceptibility of Zebrafish to Bacterial Infection. Biomolecules. 13(2):

Zhang, C., Lu, L.F., Li, Z.C., Han, K.J., Wang, X.L., Chen, D.D., Xiong, F., Li, X.Y., Zhou, L., Ge, F., Li, S. (2023) Zebrafish MAP2K7 Simultaneously Enhances Host IRF7 Stability and Degrades Spring Viremia of Carp Virus P Protein via Ubiquitination Pathway. Journal of virology. 97(7):e0053223

Gong, X.Y., Zhang, Q.M., Zhao, X., Li, Y.L., Qu, Z.L., Li, Z., Dan, C., Gui, J.F., Zhang, Y.B. (2022) LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response. iScience. 25:104821

Zhao, X., Dan, C., Gong, X.Y., Li, Y.L., Qu, Z.L., Sun, H.Y., An, L.L., Guo, W.H., Gui, J.F., Zhang, Y.B. (2022) Zebrafish MARCH8 downregulates fish IFN response by targeting MITA and TBK1 for protein degradation. Developmental and comparative immunology. 135:104485

Keatinge, M., Tsarouchas, T.M., Munir, T., Porter, N.J., Larraz, J., Gianni, D., Tsai, H.H., Becker, C.G., Lyons, D.A., Becker, T. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury. PLoS Genetics. 17:e1009515

Wu, X.M., Fang, H., Zhang, J., Bi, Y.H., Chang, M.X. (2021) Histone H2A Nuclear/Cytoplasmic Trafficking Is Essential for Negative Regulation of Antiviral Immune Response and Lysosomal Degradation of TBK1 and IRF3. Frontiers in immunology. 12:771277

Xiong, F., Cao, L., Wu, X.M., Chang, M.X. (2020) The function of zebrafish gpbar1 in antiviral response and lipid metabolism. Developmental and comparative immunology. 116:103955

Zhang, J., Wu, X.M., Hu, Y.W., Chang, M.X. (2020) A Novel Transcript Isoform of TBK1 Negatively Regulates Type I IFN Production by Promoting Proteasomal Degradation of TBK1 and Lysosomal Degradation of IRF3. Frontiers in immunology. 11:580864

Liu, S.B., Lu, L.F., Lu, X.B., Li, S., Zhang, Y.A. (2019) Zebrafish FGFR3 is a negative regulator of RLR pathway to decrease IFN expression. Fish & shellfish immunology. 92:224-229

Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26

Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613

Li, S., Lu, L.F., LaPatra, S.E., Chen, D.D., Zhang, Y.A. (2017) Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1. Developmental and comparative immunology. 67:189-201

Wu, C.C., Chen, B.S. (2016) A Systems Biology Approach to the Coordination of Defensive and Offensive Molecular Mechanisms in the Innate and Adaptive Host-Pathogen Interaction Networks. PLoS One. 11:e0149303

Sun, F., Zhang, Y.B., Liu, T.K., Shi, J., Wang, B., and Gui, J.F. (2011) Fish MITA Serves as a Mediator for Distinct Fish IFN Gene Activation Dependent on IRF3 or IRF7. Journal of immunology (Baltimore, Md. : 1950). 187(5):2531-9

Sullivan, C., Postlethwait, J.H., Lage, C.R., Millard, P.J., and Kim, C.H. (2007) Evidence for Evolving Toll-IL-1 Receptor-Containing Adaptor Molecule Function in Vertebrates. Journal of immunology (Baltimore, Md. : 1950). 178(7):4517-4527