Gene
tbk1
- ID
- ZDB-GENE-060512-359
- Name
- TANK-binding kinase 1
- Symbol
- tbk1 Nomenclature History
- Previous Names
-
- wu:fk70c05
- zgc:136548 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within negative regulation of type I interferon production and regulation of programmed cell death. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis 4. Orthologous to human TBK1 (TANK binding kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Raas et al., 2025
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| frontotemporal dementia and/or amyotrophic lateral sclerosis 4 | Alliance | Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 | 616439 |
| Autoinflammation with arthritis and vasculitis | 620880 | ||
| {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 8} | 617900 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR041087 | TANK binding kinase 1, ubiquitin-like domain |
| Domain | IPR041309 | TANK-binding kinase 1, coiled-coil domain 1 |
| Family | IPR051180 | Inhibitor of nuclear factor kappa-B kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Inhibitor of nuclear factor kappa-B kinase | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | TANK-binding kinase 1, coiled-coil domain 1 | TANK binding kinase 1, ubiquitin-like domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q0GKD6 | InterPro | 727 |
Interactions and Pathways
No data available
Plasmids
No data available