ZFIN

ZFIN ID: ZDB-GENE-060209-3

CITATIONS (64 total)

Gene Name:	interleukin 22
Gene Symbol:	il22

Liao, X., Lan, Y., Wang, W., Zhang, J., Shao, R., Yin, Z., Gudmundsson, G.H., Bergman, P., Mai, K., Ai, Q., Wan, M. (2023) Vitamin D influences gut microbiota and acetate production in zebrafish (Danio rerio) to promote intestinal immunity against invading pathogens. Gut microbes. 15:21875752187575

Rawling, M., Schiavone, M., Mugnier, A., Leclercq, E., Merrifield, D., Foey, A., Apper, E. (2023) Modulation of Zebrafish (Danio rerio) Intestinal Mucosal Barrier Function Fed Different Postbiotics and a Probiotic from Lactobacilli. Microorganisms. 11(12):

Zheng, S.Y., Shao, X., Qi, Z., Yan, M., Tao, M.H., Wu, X.M., Zhang, L., Ma, J., Li, A., Chang, M.X. (2023) Zebrafish nos2a benefits bacterial proliferation via suppressing ROS and inducing NO production to impair the expressions of inflammatory cytokines and antibacterial genes. Fish & shellfish immunology. 142:109178

Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300

Morales, R.A., Rabahi, S., Diaz, O.E., Salloum, Y., Kern, B.C., Westling, M., Luo, X., Parigi, S.M., Monasterio, G., Das, S., Hernández, P.P., Villablanca, E.J. (2022) Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine. Mucosal immunology. 15(5):940-951

Chen, R.J., Huang, C.C., Pranata, R., Lee, Y.H., Chen, Y.Y., Wu, Y.H., Wang, Y.J. (2021) Modulation of Innate Immune Toxicity by Silver Nanoparticle Exposure and the Preventive Effects of Pterostilbene. International Journal of Molecular Sciences. 22(5):

Valenzuela, L., Pacheco, S., Rincón, G., Pavez, L., Lam, N., Hernández, A.J., Dantagnan, P., González, F., Jilberto, F., Ravanal, M.C., Ramos, C., Garcia, H., Araneda, C., Ulloa, P.E. (2021) Intestinal Transcriptome Analysis Reveals Enrichment of Genes Associated with Immune and Lipid Mechanisms, Favoring Soybean Meal Tolerance in High-Growth Zebrafish (Danio Rerio). Genes. 12(5):

Xie, J., Li, M., Ye, W., Shan, J., Zhao, X., Duan, Y., Liu, Y., Unger, B.H., Cheng, Y., Zhang, W., Wu, N., Xia, X.Q. (2021) Sinomenine Hydrochloride Ameliorates Fish Foodborne Enteritis via α7nAchR-Mediated Anti-Inflammatory Effect Whilst Altering Microbiota Composition. Frontiers in immunology. 12:766845

Diaz, O.E., Xue, S., Luo, X., Nava, J., Appelblom, A., Morales, R.A., Das, S., Villablanca, E.J. (2020) Retinoic acid induced cytokines are selectively modulated by Liver X Receptor activation in zebrafish. Reproductive toxicology (Elmsford, N.Y.). 93:163-168

Ikeda-Ohtsubo, W., López Nadal, A., Zaccaria, E., Iha, M., Kitazawa, H., Kleerebezem, M., Brugman, S. (2020) Intestinal Microbiota and Immune Modulation in Zebrafish by Fucoidan From Okinawa Mozuku (Cladosiphon okamuranus). Frontiers in nutrition. 7:67

Kaya, B., Doñas, C., Wuggenig, P., Diaz, O.E., Morales, R.A., Melhem, H., Swiss IBD. Cohort Investigators, Hernández, P.P., Kaymak, T., Das, S., Hruz, P., Franc, Y., Geier, F., Ayata, C.K., Villablanca, E.J., Niess, J.H. (2020) Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1⁺ Macrophages Regulates Intestinal Homeostasis. Cell Reports. 32:107979

Li, Z., Liang, X., Liu, W., Zhao, Y., Yang, H., Li, W., Adamovsky, O., Martyniuk, C.J. (2020) Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway. Environmental pollution (Barking, Essex : 1987). 262:114291

Stressmann, F.A., Bernal-Bayard, J., Perez-Pascual, D., Audrain, B., Rendueles, O., Briolat, V., Bruchmann, S., Volant, S., Ghozlane, A., Häussler, S., Duchaud, E., Levraud, J.P., Ghigo, J.M. (2020) Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection. The ISME Journal. 15(3):702-719

Coronado, M., Solis, C.J., Hernandez, P.P., Feijóo, C.G. (2019) Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile. Frontiers in immunology. 10:610

Wu, X.M., Cao, L., Nie, P., Chang, M.X. (2019) Histone H2A cooperates with RIP2 to induce the expression of antibacterial genes and MHC related genes. Developmental and comparative immunology. 101:103455

Arias-Jayo, N., Abecia, L., Alonso-Sáez, L., Ramirez-Garcia, A., Rodriguez, A., Pardo, M.A. (2018) High-Fat Diet Consumption Induces Microbiota Dysbiosis and Intestinal Inflammation in Zebrafish. Microbial ecology. 76(4):1089-1101

Boucontet, L., Passoni, G., Thiry, V., Maggi, L., Herbomel, P., Levraud, J.P., Colucci-Guyon, E. (2018) A Model of Superinfection of Virus-Infected Zebrafish Larvae: Increased Susceptibility to Bacteria Associated With Neutrophil Death. Frontiers in immunology. 9:1084

Enya, S., Kawakami, K., Suzuki, Y., Kawaoka, S. (2018) A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor-liver crosstalk in causing adverse effects on the host.. Disease models & mechanisms. 11(8)

Hernández, P.P., Strzelecka, P.M., Athanasiadis, E.I., Hall, D., Robalo, A.F., Collins, C.M., Boudinot, P., Levraud, J.P., Cvejic, A. (2018) Single-cell transcriptional analysis reveals ILC-like cells in zebrafish. Science immunology. 3(29):

Jensen, H.M., Korbut, R., Kania, P.W., Buchmann, K. (2018) Cannabidiol effects on behaviour and immune gene expression in zebrafish (Danio rerio). PLoS One. 13:e0200016

Jørgensen, L.V.G., Korbut, R., Jeberg, S., Kania, P.W., Buchmann, K. (2018) Association between adaptive immunity and neutrophil dynamics in zebrafish (Danio rerio) infected by a parasitic ciliate. PLoS One. 13:e0203297

Lin, Y.S., Saputra, F., Chen, Y.C., Hu, S.Y. (2018) Dietary administration of Bacillus amyloliquefaciens R8 reduces hepatic oxidative stress and enhances nutrient metabolism and immunity against Aeromonas hydrophila and Streptococcus agalactiae in zebrafish (Danio rerio). Fish & shellfish immunology. 86:410-419

López Nadal, A., Peggs, D., Wiegertjes, G.F., Brugman, S. (2018) Exposure to Antibiotics Affects Saponin Immersion-Induced Immune Stimulation and Shift in Microbial Composition in Zebrafish Larvae. Frontiers in microbiology. 9:2588

López-Muñoz, A., Nicolás, F.E., García-Moreno, D., Pérez-Oliva, A.B., Navarro-Mendoza, M.I., Hernández-Oñate, M.A., Herrera-Estrella, A., Torres-Martínez, S., Ruiz-Vázquez, R.M., Garre, V., Mulero, V. (2018) An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages. Scientific Reports. 8:12802

Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11

Su, B.C., Lai, Y.W., Chen, J.Y., Pan, C.Y. (2018) Transgenic expression of tilapia piscidin 3 (TP3) in zebrafish confers resistance to Streptococcus agalactiae. Fish & shellfish immunology. 74:235-241

Haarder, S., Kania, P.W., Holm, T.L., von Gersdorff Jørgensen, L., Buchmann, K. (2017) Effect of ES-products from Anisakis (Nematoda: Anisakidae) on experimentally induced colitis in adult zebrafish. Parasite immunology. 39(10)

Mehrdana, F., Kania, P.W., Nazemi, S., Buchmann, K. (2017) Immunomodulatory effects of excretory/secretory compounds from Contracaecum osculatum larvae in a zebrafish inflammation model. PLoS One. 12:e0181277

Qiu, X., Lv, M., Jian, X., Chen, D., Zhou, H., Zhang, A., Wang, X. (2017) In vitro characterization of grass carp (Ctenopharyngodon idella) IL-26 in regulating inflammatory factors. Fish & shellfish immunology. 66:148-155

Sugimoto, K., Hui, S.P., Sheng, D.Z., Nakayama, M., Kikuchi, K. (2017) Zebrafish FOXP3 is required for the maintenance of immune tolerance. Developmental and comparative immunology. 73:156-162

Wolf, A., Aggio, J., Campbell, C., Wright, F., Marquez, G., Traver, D., Stachura, D.L. (2017) Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis. Scientific Reports. 7:44644

Xiong, S., Wu, J, Jing, J., Huang, P., Li, Z., Mei, J., Gui, J.F, (2017) Loss of stat3 function leads to spine malformation and immune disorder in zebrafish. Science Bulletin. 62:Pages 185-196

Liu, C., Su, G., Giesy, J.P., Letcher, R.J., Li, G., Agrawal, I., Li, J., Yu, L., Wang, J., Gong, Z. (2016) Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish. Scientific Reports. 6:19045

Progatzky, F., Cook, H.T., Lamb, J.R., Bugeon, L., Dallman, M.J. (2016) Mucosal inflammation at the respiratory interface: a zebrafish model. American journal of physiology. Lung cellular and molecular physiology. 310(6):L551-61

Jheng, Y.H., Lee, L.H., Ting, C.H., Pan, C.Y., Hui, C.F., Chen, J.Y. (2015) Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish & shellfish immunology. 42:1-15

Liu, X., Wu, H., Liu, Q., Wang, Q., Xiao, J., Chang, X., Zhang, Y. (2015) Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish & shellfish immunology. 45(2):342-5

Ojanen, M.J., Turpeinen, H., Cordova, Z.M., Hammarén, M.M., Harjula, S.K., Parikka, M., Rämet, M., Pesu, M. (2015) The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum. Infection and Immunity. 83(4):1431-42

Yoon, S., Mitra, S., Wyse, C., Alnabulsi, A., Zou, J., Weerdenburg, E.M., van der Sar, A.M., Wang, D., Secombes, C.J., Bird, S. (2015) First Demonstration of Antigen Induced Cytokine Expression by CD4-1+ Lymphocytes in a Poikilotherm: Studies in Zebrafish (Danio rerio). PLoS One. 10:e0126378

Wang, Y.D., Peng, K.C., Wu, J.L., Chen, J.Y. (2014) Transgenic expression of salmon delta-5 and delta-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity. Fish & shellfish immunology. 39(2):223-30

Witte, M., Huitema, L.F., Nieuwenhuis, E.E., Brugman, S. (2014) Deficiency in Macrophage-Stimulating Protein Results in Spontaneous Intestinal Inflammation and Increased Susceptibility Toward Epithelial Damage in Zebrafish. Zebrafish. 11(6):542-50

Zhang, H., Shen, B., Wu, H., Gao, L., Liu, Q., Wang, Q., Xiao, J., Zhang, Y. (2014) Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarum via different vaccination routes. Fish & shellfish immunology. 37:229-38

Costa, M.M., Saraceni, P.R., Forn-Cuní, G., Dios, S., Romero, A., Figueras, A., and Novoa, B. (2013) IL-22 is a key player in the regulation of inflammation in fish and involves innate immune cells and PI3K signaling. Developmental and comparative immunology. 41(4):746-755

Zhang, H., Fei, C., Wu, H., Yang, M., Liu, Q., Wang, Q., and Zhang, Y. (2013) Transcriptome Profiling Reveals Th17-Like Immune Responses Induced in Zebrafish Bath-Vaccinated with a Live Attenuated Vibrio anguillarum. PLoS One. 8(9):e73871

Rendueles, O., Ferrières, L., Frétaud, M., Bégaud, E., Herbomel, P., Levraud, J.P., and Ghigo, J.M. (2012) A new zebrafish model of Oro-intestinal pathogen colonization reveals a key role for adhesion in protection by probiotic bacteria. PLoS pathogens. 8(7):e1002815

Wu, T.H., Pan, C.Y., Lin, M.C., Hsieh, J.C., Hui, C.F., and Chen, J.Y. (2012) In vivo screening of zebrafish microRNA responses to bacterial infection and their possible roles in regulating immune response genes after lipopolysaccharide stimulation. Fish physiology and biochemistry. 38(5):1299-1310

Pan, C.Y., Peng, K.C., Lin, C.H., and Chen, J.Y. (2011) Transgenic expression of tilapia hepcidin 1-5 and shrimp chelonianin in zebrafish and their resistance to bacterial pathogens. Fish & shellfish immunology. 31(2):275-85

Wang, W.L., Liu, W., Gong, H.Y., Hong, J.R., Lin, C.C., and Wu, J.L. (2011) Activation of cytokine expression occurs through the tnfα/nf-κb-mediated pathway in birnavirus-infected cells. Fish & shellfish immunology. 31(1):10-21

Encinas, P., Rodriguez-Milla, M.A., Novoa, B., Estepa, A., Figueras, A., and Coll, J. (2010) Zebrafish fin immune responses during high mortality infections with viral haemorrhagic septicemia rhabdovirus. A proteomic and transcriptomic approach. BMC Genomics. 11:518

Hsieh, J.C., Pan, C.Y., and Chen, J.Y. (2010) Tilapia hepcidin (TH)2-3 as a transgene in transgenic fish enhances resistance to Vibrio vulnificus infection and causes variations in immune-related genes after infection by different bacterial species. Fish & shellfish immunology. 29(3):430-439

Peng, K.C., Pan, C.Y., Chou, H.N., and Chen, J.Y. (2010) Using an improved Tol2 transposon system to produce transgenic zebrafish with epinecidin-1 which enhanced resistance to bacterial infection. Fish & shellfish immunology. 28(5-6):905-917

Stein, C., Caccamo, M., Laird, G., and Leptin, M. (2007) Conservation and divergence of gene families encoding components of innate immune response systems in the zebrafish. Genome biology. 8(11):R251

Igawa, D., Sakai, M., Savan, R. (2006) An unexpected discovery of two interferon gamma-like genes along with interleukin (IL)-22 and -26 from teleost: IL-22 and -26 genes have been described for the first time outside mammals. Molecular immunology. 43(7):999-1009

Krause, C.D., and Pestka, S. (2005) Evolution of the Class 2 cytokines and receptors, and discovery of new friends and relatives. Pharmacology & Therapeutics. 106(3):299-346

Additional Citations (11):

ZFIN Staff (2023) Curation of NCBI Gene Data Via Shared Ensembl IDs (Supplemental NCBI Load). Automated Data Submission.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2019) Semi-automated association of ENSDARG and ENSDART identifiers with ZFIN genes and transcripts. Semi-automated Curation.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Varshney, G.K., Zhang, S., Burgess, S.M., ZFIN Staff (2015) Automated Data Load From CRISPRz. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

ZFIN Staff (2013) Curation of NCBI Gene Data Via Shared Vega Gene IDs. Automated Data Submission.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2004) Temporary Manual Curation. Manually curated data.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.