Gene
il22
- ID
- ZDB-GENE-060209-3
- Name
- interleukin 22
- Symbol
- il22 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Acts upstream of or within defense response to Gram-negative bacterium; immune response; and regulation of inflammatory response. Is expressed in several structures, including bone tissue; caudal fin; heart; liver; and pleuroperitoneal region. Orthologous to human IL22 (interleukin 22).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Homologous_superfamily | IPR009079 | Four-helical cytokine-like, core |
Domain Details Per Protein
| Protein | Additional Resources | Length | Four-helical cytokine-like, core |
|---|---|---|---|
| UniProtKB:Q5TLE4 | InterPro PDB | 213 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020792 (1) | 642 nt | ||
| Genomic | GenBank:BX465210 (1) | 171708 nt | ||
| Polypeptide | UniProtKB:Q5TLE4 (1) | 213 aa |
- Liao, X., Lan, Y., Wang, W., Zhang, J., Shao, R., Yin, Z., Gudmundsson, G.H., Bergman, P., Mai, K., Ai, Q., Wan, M. (2023) Vitamin D influences gut microbiota and acetate production in zebrafish (Danio rerio) to promote intestinal immunity against invading pathogens. Gut microbes. 15:21875752187575
- Rawling, M., Schiavone, M., Mugnier, A., Leclercq, E., Merrifield, D., Foey, A., Apper, E. (2023) Modulation of Zebrafish (Danio rerio) Intestinal Mucosal Barrier Function Fed Different Postbiotics and a Probiotic from Lactobacilli. Microorganisms. 11(12):
- Zheng, S.Y., Shao, X., Qi, Z., Yan, M., Tao, M.H., Wu, X.M., Zhang, L., Ma, J., Li, A., Chang, M.X. (2023) Zebrafish nos2a benefits bacterial proliferation via suppressing ROS and inducing NO production to impair the expressions of inflammatory cytokines and antibacterial genes. Fish & shellfish immunology. 142:109178
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Morales, R.A., Rabahi, S., Diaz, O.E., Salloum, Y., Kern, B.C., Westling, M., Luo, X., Parigi, S.M., Monasterio, G., Das, S., Hernández, P.P., Villablanca, E.J. (2022) Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine. Mucosal immunology. 15(5):940-951
- Chen, R.J., Huang, C.C., Pranata, R., Lee, Y.H., Chen, Y.Y., Wu, Y.H., Wang, Y.J. (2021) Modulation of Innate Immune Toxicity by Silver Nanoparticle Exposure and the Preventive Effects of Pterostilbene. International Journal of Molecular Sciences. 22(5):
- Valenzuela, L., Pacheco, S., Rincón, G., Pavez, L., Lam, N., Hernández, A.J., Dantagnan, P., González, F., Jilberto, F., Ravanal, M.C., Ramos, C., Garcia, H., Araneda, C., Ulloa, P.E. (2021) Intestinal Transcriptome Analysis Reveals Enrichment of Genes Associated with Immune and Lipid Mechanisms, Favoring Soybean Meal Tolerance in High-Growth Zebrafish (Danio Rerio). Genes. 12(5):
- Xie, J., Li, M., Ye, W., Shan, J., Zhao, X., Duan, Y., Liu, Y., Unger, B.H., Cheng, Y., Zhang, W., Wu, N., Xia, X.Q. (2021) Sinomenine Hydrochloride Ameliorates Fish Foodborne Enteritis via α7nAchR-Mediated Anti-Inflammatory Effect Whilst Altering Microbiota Composition. Frontiers in immunology. 12:766845
- Diaz, O.E., Xue, S., Luo, X., Nava, J., Appelblom, A., Morales, R.A., Das, S., Villablanca, E.J. (2020) Retinoic acid induced cytokines are selectively modulated by Liver X Receptor activation in zebrafish. Reproductive toxicology (Elmsford, N.Y.). 93:163-168
- Ikeda-Ohtsubo, W., López Nadal, A., Zaccaria, E., Iha, M., Kitazawa, H., Kleerebezem, M., Brugman, S. (2020) Intestinal Microbiota and Immune Modulation in Zebrafish by Fucoidan From Okinawa Mozuku (Cladosiphon okamuranus). Frontiers in nutrition. 7:67
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