ZFIN

ZFIN ID: ZDB-GENE-040219-9

ZFIN ID: ZDB-GENE-040219-9

CITATIONS (83 total)

Gene Name:	toll-like receptor 4b, duplicate b
Gene Symbol:	tlr4bb

Weiss, A., D'Amata, C., Pearson, B.J., Hayes, M.N. (2024) A syngeneic spontaneous zebrafish model of tp53-deficient, EGFR^vIII, and PI3KCA^H1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo. eLIFE. 13:

Zhang, Z., Zhang, H.L., Yang, D.H., Hao, Q., Yang, H.W., Meng, D.L., Meindert de Vos, W., Guan, L.L., Liu, S.B., Teame, T., Gao, C.C., Ran, C., Yang, Y.L., Yao, Y.Y., Ding, Q.W., Zhou, Z.G. (2024) Lactobacillus rhamnosus GG triggers intestinal epithelium injury in zebrafish revealing host dependent beneficial effects. iMeta. 3:e181e181

Bian, W.P., Xie, S.L., Wang, C., Martinovich, G.G., Ma, Y.B., Jia, P.P., Pei, D.S. (2023) mitfa deficiency promotes immune vigor and potentiates antitumor effects in zebrafish. Fish & shellfish immunology. 142:109130

Wu, J., Lin, X., Wu, D., Yan, B., Bao, M., Zheng, P., Wang, J., Yang, C., Li, Z., Jin, X., Jiang, K. (2023) Poly(I:C)-exposed zebrafish shows autism-like behaviors which are ameliorated by fabp2 gene knockout. Frontiers in molecular neuroscience. 15:10680191068019

Chen, Q., Wei, T., Yang, B., Li, S., Ge, L., Zhou, A., Xie, S. (2022) The Impact of Deleting the mitfa gene in Zebrafish on the Intestinal Microbiota Community. Gene. 846:146870

Ma, K., Chen, S., Wu, Y., Ma, Y., Qiao, H., Fan, J., Wu, H. (2022) Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota. Applied Microbiology and Biotechnology. 106(2):773-788

Tyrkalska, S.D., Martínez-López, A., Pedoto, A., Candel, S., Cayuela, M.L., Mulero, V. (2022) The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish. Developmental and comparative immunology. 140:104626

Xiao, X., Liu, Z., Su, G., Liu, H., Yin, W., Guan, Y., Jing, S., Du, L., Li, F., Li, N., Yang, P. (2022) A novel uveitis model induced by lipopolysaccharide in zebrafish. Frontiers in immunology. 13:10428491042849

Chen, J., Tchivelekete, G.M., Zhou, X., Tang, W., Liu, F., Liu, M., Zhao, C., Shu, X., Zeng, Z. (2021) Anti-inflammatory activities of Gardenia jasminoides extracts in retinal pigment epithelial cells and zebrafish embryos. Experimental and Therapeutic Medicine. 22:700

Chen, Z., Zhijie, C., Yuting, Z., Chan, L., Shilin, X., Qichun, Z., Jinying, O., Jing, L., Chaohua, L., Zhixian, M. (2021) The Ameliorative Effects of Isorhynchophylline on Morphine Dependence Are Mediated Through the Microbiota-Gut-Brain Axis. Frontiers in pharmacology. 12:526923

Loes, A.N., Hinman, M.N., Farnsworth, D.R., Miller, A.C., Guillemin, K., Harms, M.J. (2021) Identification and Characterization of Zebrafish Tlr4 Coreceptor Md-2. Journal of immunology (Baltimore, Md. : 1950). 206(5):1046-1057

Luo, T., Wang, X., Jin, Y. (2021) Low concentrations of imidacloprid exposure induced gut toxicity in adult zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 241:108972

Shan, S., Liu, R., Feng, H., Meng, F., Aizaz, M., Yang, G. (2021) Identification and functional characterization of a fish-specific tlr19 in common carp (Cyprinus carpio L.) that recruits TRIF as an adaptor and induces ifn expression during the immune response. Veterinary research. 52:88

Sireswar, S., Dey, G., Biswas, S. (2021) Influence of fruit-based beverages on efficacy of Lacticaseibacillus rhamnosus GG (Lactobacillus rhamnosus GG) against DSS-induced intestinal inflammation. Food research international (Ottawa, Ont.). 149:110661

Wasana, W.P., Senevirathne, A., Nikapitiya, C., Eom, T.Y., Lee, Y., Lee, J.S., Kang, D.H., Oh, C., De Zoysa, M. (2021) A Novel Pseudoalteromonas xiamenensis Marine Isolate as a Potential Probiotic: Anti-Inflammatory and Innate Immune Modulatory Effects against Thermal and Pathogenic Stresses. Marine drugs. 19(12):

Cheng, B., Zhang, H., Hu, J., Peng, Y., Yang, J., Liao, X., Liu, F., Guo, J., Hu, C., Lu, H. (2020) The immunotoxicity and neurobehavioral toxicity of zebrafish induced by famoxadone-cymoxanil. Chemosphere. 247:125870

Liyanage, T.D., Dahanayake, P.S., Edirisinghe, S.L., Nikapitiya, C., Heo, G.J., De Zoysa, M., Whang, I. (2020) Biological Activity of Porcine Gastric Mucin on Stress Resistance and Immunomodulation. Molecules. 25(13):

Pacheco, I., Contreras, M., Villar, M., Risalde, M.A., Alberdi, P., Cabezas-Cruz, A., Gortázar, C., de la Fuente, J. (2020) Vaccination with Alpha-Gal Protects Against Mycobacterial Infection in the Zebrafish Model of Tuberculosis. Vaccines. 8(2):

van den Bos, R., Cromwijk, S., Tschigg, K., Althuizen, J., Zethof, J., Whelan, R., Flik, G., Schaaf, M. (2020) Early Life Glucocorticoid Exposure Modulates Immune Function in Zebrafish (Danio rerio) Larvae. Frontiers in immunology. 11:727

Xin, G., Li, W.G., Yoganandham, S.T., Jia, P.P., Ma, Y.B., Pei, D.S. (2020) Gut bacteria Vibrio sp. and Aeromonas sp. trigger the expression levels of proinflammatory cytokine: First evidence from the germ-free zebrafish. Fish & shellfish immunology. 106:518-525

Aksakal, F.I., Ciltas, A. (2019) Impact of copper oxide nanoparticles (CuO NPs) exposure on embryo development and expression of genes related to the innate immune system of zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 223:78-87

Cheng, B., Zhang, H., Jia, K., Li, E., Zhang, S., Yu, H., Cao, Z., Xiong, G., Hu, C., Lu, H. (2019) Effects of spinetoram on the developmental toxicity and immunotoxicity of zebrafish. Fish & shellfish immunology. 96:114-121

Edirisinghe, S.L., Dananjaya, S.H.S., Nikapitiya, C., Liyanage, T.D., Lee, K.A., Oh, C., Kang, D.H., De Zoysa, M. (2019) Novel pectin isolated from Spirulina maxima enhances the disease resistance and immune responses in zebrafish against Edwardsiella piscicida and Aeromonas hydrophila. Fish & shellfish immunology. 94:558-565

Icoglu Aksakal, F., Ciltas, A., Simsek Ozek, N. (2019) A holistic study on potential toxic effects of carboxylated multi-walled carbon nanotubes (MWCNTs-COOH) on zebrafish (Danio rerio) embryos/larvae. Chemosphere. 225:820-828

Lin, W., Guo, H., Wang, L., Zhang, D., Wu, X., Li, L., Qiu, Y., Yang, L., Li, D., Tang, R. (2019) Parental transfer of microcystin-LR induced innate immune dysfunction of zebrafish: A cross-generational study. Environmental science & technology. 54(2):1014-1023

Qiu, W., Chen, B., Greer, J., Magnuson, J., Xiong, Y., Zhong, H., Andrzejczyk, N.E., Zheng, C., Schlenk, D. (2019) Transcriptomic responses of Bisphenol S predict involvement of immune function in the cardiotoxicity of early life stage zebrafish (Danio rerio). Environmental science & technology. 54(5):2869-2877

Wu, N., Xu, X., Wang, B., Li, X.M., Cheng, Y.Y., Li, M., Xia, X.Q., Zhang, Y.A. (2019) Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish. Fish & shellfish immunology. 97:204-215

Zhang, Z., Ran, C., Ding, Q.W., Liu, H.L., Xie, M.X., Yang, Y.L., Xie, Y.D., Gao, C.C., Zhang, H.L., Zhou, Z.G. (2019) Ability of prebiotic polysaccharides to activate a HIF1α-antimicrobial peptide axis determines liver injury risk in zebrafish. Communications biology. 2:274

Arias-Jayo, N., Abecia, L., Alonso-Sáez, L., Ramirez-Garcia, A., Rodriguez, A., Pardo, M.A. (2018) High-Fat Diet Consumption Induces Microbiota Dysbiosis and Intestinal Inflammation in Zebrafish. Microbial ecology. 76(4):1089-1101

Chandrarathna, H.P.S.U., Nikapitiya, C., Dananjaya, S.H.S., Wijerathne, C.U.B., Wimalasena, S.H.M.P., Kwon, H.J., Heo, G.J., Lee, J., De Zoysa, M. (2018) Outcome of co-infection with opportunistic and multidrug resistant Aeromonas hydrophila and A. veronii in zebrafish: Identification, characterization, pathogenicity and immune responses. Fish & shellfish immunology. 80:573-581

Liu, G.P., Xiang, L.X., Shao, T., Lin, A.F., Shao, J.Z. (2018) Stimulatory function of peroxiredoxin 1 in activating adaptive humoral immunity in a zebrafish model. Developmental and comparative immunology. 84:353-360

Pérez-Ramos, A., Mohedano, M.L., Pardo, M.Á., López, P. (2018) β-Glucan-Producing Pediococcus parvulus 2.6: Test of Probiotic and Immunomodulatory Properties in Zebrafish Models.. Frontiers in microbiology. 9:1684

Xiong, G., Zou, L., Deng, Y., Meng, Y., Liao, X., Lu, H. (2018) Clethodim exposure induces developmental immunotoxicity and neurobehavioral dysfunction in zebrafish embryos. Fish & shellfish immunology. 86:549-558

Zhou, S., Wei, Z., Chu, T., Yu, H., Li, S., Zhang, W., Gui, W. (2018) Transcriptomic analysis of zebrafish (Danio rerio) embryos to assess integrated biotoxicity of Xitiaoxi River waters. Environmental pollution (Barking, Essex : 1987). 242:42-53

Hu, Y.W., Wu, X.M., Ren, S.S., Cao, L., Nie, P., Chang, M.X. (2017) NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Scientific Reports. 7:2979

Philip, A.M., Wang, Y., Mauro, A., El-Rass, S., Marshall, J.C., Lee, W.L., Slutsky, A.S., dos Santos, C.C., Wen, X.Y. (2017) Development of a zebrafish sepsis model for high-throughput drug discovery. Molecular medicine (Cambridge, Mass.). 23:134-148

Shin, S., Kulatunga, D.C.M., Dananjaya, S.H.S., Nikapitiya, C., Lee, J., De Zoysa, M. (2017) Saprolegnia parasitica Isolated from Rainbow Trout in Korea: Characterization, Anti-Saprolegnia Activity and Host Pathogen Interaction in Zebrafish Disease Model.. Mycobiology. 45:297-311

Wang, C., Chen, Y.L., Bian, W.P., Xie, S.L., Qi, G.L., Liu, L., Strauss, P.R., Zou, J.X., Pei, D.S. (2017) Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish. Fish & shellfish immunology. 72:572-580

Chang, M.Y., Cheng, Y.C., Hsu, S.H., Ma, T.L., Chou, L.F., Hsu, H.H., Tian, Y.C., Chen, Y.C., Sun, Y.J., Hung, C.C., Pan, R.L., Yang, C.W. (2016) Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae. Scientific Reports. 6:27838

Candel, S., Sepulcre, M.P., Espín-Palazón, R., Tyrkalska, S.D., de Oliveira, S., Meseguer, J., Mulero, V. (2015) Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish. Developmental and comparative immunology. 50(2):155-65

He, Q., Zhang, C., Wang, L., Zhang, P., Ma, D., Lv, J., Liu, F. (2015) Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 125(7):1098-106

Jheng, Y.H., Lee, L.H., Ting, C.H., Pan, C.Y., Hui, C.F., Chen, J.Y. (2015) Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish & shellfish immunology. 42:1-15

Oyarbide, U., Iturria, I., Rainieri, S., Pardo, M.A. (2015) Use of Gnotobiotic Zebrafish to Study Vibrio anguillarum Pathogenicity. Zebrafish. 12(1):71-80

Sun, Z., Shen, B., Wu, H., Zhou, X., Wang, Q., Xiao, J., Zhang, Y. (2015) The secreted fructose 1,6-bisphosphate aldolase as a broad spectrum vaccine candidate against pathogenic bacteria in aquaculture. Fish & shellfish immunology. 46(2):638-47

Tong, C., Zhang, C., Zhang, R., Zhao, K. (2015) Transcriptome profiling analysis of naked carp (Gymnocypris przewalskii) provides insights into the immune-related genes in highland fish. Fish & shellfish immunology. 46(2):366-77

Gao, Y., Wu, H., Wang, Q., Qu, J., Liu, Q., Xiao, J., Zhang, Y. (2014) A live attenuated combination vaccine evokes effective immune-mediated protection against Edwardsiella tarda and Vibrio anguillarum. Vaccine. 32(45):5937-44

Liu, X., Wu, H., Chang, X., Tang, Y., Liu, Q., Zhang, Y. (2014) Notable mucosal immune responses induced in the intestine of zebrafish (Danio rerio) bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish & shellfish immunology. 40(1):99-108

Pietretti, D., Scheer, M., Fink, I.R., Taverne, N., Savelkoul, H.F., Spaink, H.P., Forlenza, M., and Wiegertjes, G.F. (2014) Identification and functional characterization of nonmammalian Toll-like receptor 20. Immunogenetics. 66(2):123-141

Gao, H., Wu, L., Sun, J.S., Geng, X.Y., and Pan, B.P. (2013) Molecular characterization and expression analysis of Toll-like receptor 21 cDNA from Paralichthys olivaceus. Fish & shellfish immunology. 35(4):1138-45

Kanwal, Z., Zakrzewska, A., den Hertog, J., Spaink, H.P., Schaaf, M.J., and Meijer, A.H. (2013) Deficiency in Hematopoietic Phosphatase Ptpn6/Shp1 Hyperactivates the Innate Immune System and Impairs Control of Bacterial Infections in Zebrafish Embryos. Journal of immunology (Baltimore, Md. : 1950). 190(4):1631-1645

Lee, S.H., Peng, K.C., Lee, L.H., Pan, C.Y., Hour, A.L., Her, G.M., Hui, C.F., and Chen, J.Y. (2013) Characterization of tilapia (Oreochromis niloticus) viperin expression, and inhibition of bacterial growth and modulation of immune-related gene expression by electrotransfer of viperin DNA into zebrafish muscle. Veterinary Immunology and Immunopathology. 151(3-4):217-228

Yeh, D.W., Liu, Y.L., Lo, Y.C., Yuh, C.H., Yu, G.Y., Lo, J.F., Luo, Y., Xiang, R., and Chuang, T.H. (2013) Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 110(51):20711-20716

Petrey, A.C., Flanagan-Steet, H., Johnson, S., Fan, X., De la Rosa, M., Haskins, M.E., Nairn, A.V., Moremen, K.W., and Steet, R. (2012) Excessive activity of cathepsin K is associated with the cartilage defects in a zebrafish model for mucolipidosis II. Disease models & mechanisms. 5(2):177-190

Rotman, J., van Gils, W., Butler, D., Spaink, H.P., and Meijer, A.H. (2011) Rapid screening of innate immune gene expression in zebrafish using reverse transcription - multiplex ligation-dependent probe amplification. BMC research notes. 4(1):196

Sepulcre, M.P., Alcaraz-Pérez, F., López-Muñoz, A., Roca, F.J., Meseguer, J., Cayuela, M.L., and Mulero, V. (2009) Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation. Journal of immunology (Baltimore, Md. : 1950). 182(4):1836-1845

Su, J., Yang, C., Xiong, F., Wang, Y., and Zhu, Z. (2009) Toll-like receptor 4 signaling pathway can be triggered by grass carp reovirus and Aeromonas hydrophila infection in rare minnow Gobiocypris rarus. Fish & shellfish immunology. 27(1):33-39

Sullivan, C., Charette, J., Catchen, J., Lage, C.R., Giasson, G., Postlethwait, J.H., Millard, P.J., and Kim, C.H. (2009) The Gene History of Zebrafish tlr4a and tlr4b Is Predictive of Their Divergent Functions. Journal of immunology (Baltimore, Md. : 1950). 183(9):5896-5908

Novoa, B., Romero, A., Mulero, V., Rodriguez, I., Fernandez, I., and Figueras, A. (2006) Zebrafish (Danio rerio) as a model for the study of vaccination against viral haemorrhagic septicemia virus (VHSV). Vaccine. 24(31-31):5806-5816

van der Sar, A.M., Stockhammer, O.W., van der Laan, C., Spaink, H.P., Bitter, W., and Meijer, A.H. (2006) MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model. Infection and Immunity. 74(4):2436-2441

Phelps, H.A., and Neely, M.N. (2005) Evolution of the Zebrafish Model: From Development to Immunity and Infectious Disease. Zebrafish. 2(2):87-103

Jault, C., Pichon, L., and Chluba, J. (2004) Toll-like receptor gene family and TIR-domain adapters in Danio rerio. Molecular immunology. 40(11):759-771

Meijer, A.H., Gabby Krens, S.F., Medina Rodriguez, I.A., He, S., Bitter, W., Snaar-Jagalska, Ewa B., and Spaink, H.P. (2004) Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Molecular immunology. 40(11):773-783

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (20):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

Moens, C.B. and ZFIN Staff (2009) Curation of TILLING Database Links. ZFIN Direct Data Submission.

ZIRC and ZFIN Staff (2008) Mutant and Transgenic Line Submissions 2008. ZFIN Direct Data Submission.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, C., and Thisse, B. (2005) High Throughput Expression Analysis of ZF-Models Consortium Clones. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.