ZFIN

ZFIN ID: ZDB-GENE-030131-5415

ZFIN ID: ZDB-GENE-030131-5415

CITATIONS (72 total)

Gene Name:	Rac family small GTPase 1a
Gene Symbol:	rac1a

Doan, R.A., Monk, K.R. (2025) Dock1 functions in Schwann cells to regulate development, maintenance, and repair. The Journal of cell biology. 224:

Wang, Y., Nguyen, T., He, Q., Has, O., Forouzesh, K., Eom, D.S. (2025) Cytoneme-mediated intercellular signaling in keratinocytes is essential for epidermal remodeling in zebrafish. eLIFE. 13:

Jiang, R.X., Hu, N., Deng, Y.W., Hu, L.W., Gu, H., Luo, N., Wen, J., Jiang, X.Q. (2024) Potential therapeutic role of spermine via Rac1 in osteoporosis: Insights from zebrafish and mice. Zoological research. 45:367380367-380

Singh, S., Danda, S., Sharma, N., Shah, H., Madhuri, V., Mir, T.A., Padala, N.Z., Medishetti, R., Ekbote, A., Bhavani, G.S., Sevilimedu, A., Girisha, K.M. (2024) Biallelic variants in CCN2 underlie an autosomal recessive kyphomelic dysplasia. European journal of human genetics : EJHG. 33(1):30-37

Zhou, X., Lian, K., Jia, J., Zhao, X., Duan, P., Huang, J., Shi, Y. (2024) Functions of Epimedin C in a zebrafish model of glucocorticoid-induced osteoporosis. Journal of Cellular and Molecular Medicine. 28:e18569e18569

Cheng, T., Xing, Y.Y., Liu, C., Li, Y.F., Huang, Y., Liu, X., Zhang, Y.J., Zhao, G.Q., Dong, Y., Fu, X.X., Tian, Y.M., Shu, L.P., Megason, S.G., Xu, P.F. (2023) Nodal coordinates the anterior-posterior patterning of germ layers and induces head formation in zebrafish explants. Cell Reports. 42:112351112351

Lu, Y., Tang, D., Zheng, Z., Wang, X., Zuo, N., Yan, R., Wu, C., Ma, J., Wang, C., Xu, H., He, Y., Liu, D., Liu, S. (2022) Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Frontiers in molecular neuroscience. 15:844668

Chiang, K.Y., Li, Y.W., Li, Y.H., Huang, S.J., Wu, C.L., Gong, H.Y., Wu, J.L. (2021) Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish. International Journal of Molecular Sciences. 22(20):

Li, Z., Li, B., Wang, J., Lu, Y., Chen, A.F.Y., Sun, K., Yu, Y., Chen, S. (2021) GAA deficiency promotes angiogenesis through upregulation of Rac1 induced by autophagy disorder. Biochimica et biophysica acta. Molecular cell research. 1868(5):118969

Harris, J.M., Wang, A.Y., Boulanger-Weill, J., Santoriello, C., Foianini, S., Lichtman, J.W., Zon, L.I., Arlotta, P. (2020) Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects. Developmental Cell. 53:577-588.e7

Klems, A., van Rijssel, J., Ramms, A.S., Wild, R., Hammer, J., Merkel, M., Derenbach, L., Préau, L., Hinkel, R., Suarez-Martinez, I., Schulte-Merker, S., Vidal, R., Sauer, S., Kivelä, R., Alitalo, K., Kupatt, C., van Buul, J.D., le Noble, F. (2020) The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models. Nature communications. 11:5319

Chen, M., Luo, Y., Xu, J., Chang, M.X., Liu, J.X. (2019) Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival. Frontiers in immunology. 10:2599

Mikdache, A., Fontenas, L., Albadri, S., Revenu, C., Loisel-Duwattez, J., Lesport, E., Degerny, C., Del Bene, F., Tawk, M. (2019) Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish. Cellular and molecular life sciences : CMLS. 77(1):161-177

Shamipour, S., Kardos, R., Xue, S.L., Hof, B., Hannezo, E., Heisenberg, C.P. (2019) Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes. Cell. 177(6):1463-1479.e18

Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26

Zhu, Y., Crowley, S.C., Latimer, A.J., Lewis, G.M., Nash, R., Kucenas, S. (2019) Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System. Cell. 179(1):74-89.e10

Hübner, K., Cabochette, P., Diéguez-Hurtado, R., Wiesner, C., Wakayama, Y., Grassme, K.S., Hubert, M., Guenther, S., Belting, H.G., Affolter, M., Adams, R.H., Vanhollebeke, B., Herzog, W. (2018) Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nature communications. 9:4860

Swinburne, I.A., Mosaliganti, K.R., Upadhyayula, S., Liu, T.L., Hildebrand, D.G.C., Tsai, T.Y., Chen, A., Al-Obeidi, E., Fass, A.K., Malhotra, S., Engert, F., Lichtman, J.W., Kirchausen, T., Betzig, E., Megason, S.G. (2018) Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure. eLIFE. 7

Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613

Razaghi, B., Steele, S.L., Prykhozhij, S.V., Stoyek, M.R., Hill, J.A., Cooper, M.D., McDonald, L., Lin, W., Daugaard, M., Crapoulet, N., Chacko, S., Lewis, S., Scott, I.C., Sorensen, P.H.B., Berman, J.N. (2017) hace1 influences zebrafish cardiac development via ROS-dependent mechanisms. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(2):289-303

Reijnders, M.R.F., Ansor, N.M., Kousi, M., Yue, W.W., Tan, P.L., Clarkson, K., Clayton-Smith, J., Corning, K., Jones, J.R., Lam, W.W.K., Mancini, G.M.S., Marcelis, C., Mohammed, S., Pfundt, R., Roifman, M., Cohn, R., Chitayat, D., Millard, T.H., Katsanis, N., Brunner, H.G., Banka, S. (2017) RAC1 Missense Mutations in Developmental Disorders with Diverse Phenotypes. American journal of human genetics. 101:466-477

Chen, J., Tanguay, R.L., Xiao, Y., Haggard, D.E., Ge, X., Jia, Y., Zheng, Y., Dong, Q., Huang, C., Lin, K. (2016) TBBPA exposure during a sensitive developmental window produces neurobehavioral changes in larval zebrafish. Environmental pollution (Barking, Essex : 1987). 216:53-63

Rosowski, E.E., Deng, Q., Keller, N.P., Huttenlocher, A. (2016) Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 197(12):4780-4790

Wan, X., Lee, M.S., Zhou, W. (2016) Dosage-dependent Role of RAC1 in Podocyte Injury. American journal of physiology. Renal physiology. 310(8):F777-F784

Wang, Q., Liu, S., Hu, D., Wang, Z., Wang, L., Wu, T., Wu, Z., Mohan, C., Peng, A. (2016) Identification of apoptosis and macrophage migration events in paraquat-induced oxidative stress using a zebrafish model. Life sciences. 157:116-24

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Epting, D., Slanchev, K., Boehlke, C., Hoff, S., Loges, N.T., Yasunaga, T., Indorf, L., Nestel, S., Lienkamp, S.S., Omran, H., Kuehn, E.W., Ronneberger, O., Walz, G., Kramer-Zucker, A. (2015) The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin. Development (Cambridge, England). 142:174-84

Ningappa, M., So, J., Glessner, J., Ashokkumar, C., Ranganathan, S., Min, J., Higgs, B.W., Sun, Q., Haberman, K., Schmitt, L., Vilarinho, S., Mistry, P.K., Vockley, G., Dhawan, A., Gittes, G.K., Hakonarson, H., Jaffe, R., Subramaniam, S., Shin, D., Sindhi, R. (2015) The Role of ARF6 in Biliary Atresia. PLoS One. 10:e0138381

Choe, C.P., Collazo, A., Trinh, L.A., Pan, L., Moens, C.B., and Crump, J.G. (2013) Wnt-Dependent Epithelial Transitions Drive Pharyngeal Pouch Formation. Developmental Cell. 24(3):296-309

Encinas, P., Garcia-Valtanen, P., Chinchilla, B., Gomez-Casado, E., Estepa, A., and Coll, J. (2013) Identification of Multipath Genes Differentially Expressed in Pathway-Targeted Microarrays in Zebrafish Infected and Surviving Spring Viremia Carp Virus (SVCV) Suggest Preventive Drug Candidates. PLoS One. 8(9):e73553

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Hsu, C.L., Muerdter, C.P., Knickerbocker, A.D., Walsh, R.M., Zepeda-Rivera, M.A., Depner, K.H., Sangesland, M., Cisneros, T.B., Kim, J.Y., Sanchez-Vazquez, P., Cherezova, L., Regan, R.D., Bahrami, N.M., Gray, E.A., Chan, A.Y., Chen, T., Rao, M.Y., and Hille, M.B. (2012) Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(10):1545-1561

Jayasena, C.S., and Bronner, M.E. (2012) Rbms3 functions in craniofacial development by posttranscriptionally modulating TGF-β signaling. The Journal of cell biology. 199(3):453-466

Oberoi, T.K., Dogan, T., Hocking, J.C., Scholz, R.P., Mooz, J., Anderson, C.L., Karreman, C., Heringdorf, D., Schmidt, G., Ruonala, M., Namikawa, K., Harms, G.S., Carpy, A., Macek, B., Köster, R.W., and Rajalingam, K. (2012) IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation. The EMBO journal. 31(1):14-28

Tell, R.M., Kimura, K., and Pali, D. (2012) Rac2 expression and its role in neutrophil functions of zebrafish (Danio rerio). Fish & shellfish immunology. 33(5):1086-1094

Xu, H., Kardash, E., Chen, S., Raz, E., and Lin, F. (2012) Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity. Development (Cambridge, England). 139(1):57-62

Deng, Q., Yoo, S.K., Cavnar, P.J., Green, J.M., and Huttenlocher, A. (2011) Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue. Developmental Cell. 21(4):735-745

Yeh, C.M., Liu, Y.C., Chang, C.J., Lai, S.L., Hsiao, C.D., and Lee, S.J. (2011) Ptenb Mediates Gastrulation Cell Movements via Cdc42/AKT1 in Zebrafish. PLoS One. 6(4):e18702

Kardash, E., Reichman-Fried, M., Maître, J.L., Boldajipour, B., Papusheva, E., Messerschmidt, E.M., Heisenberg, C.P., and Raz, E. (2010) A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo. Nature cell biology. 12(1):47-53

Li, Y.H., Chen, M.H., Gong, H.Y., Hu, S.Y., Li, Y.W., Lin, G.H., Lin, C.C., Liu, W., and Wu, J.L. (2010) Progranulin A-mediated MET signaling is essential for liver morphogenesis in zebrafish. The Journal of biological chemistry. 285(52):41001-41009

Michailidou, C., Jones, M., Walker, P., Kamarashev, J., Kelly, A., and Hurlstone, A.F. (2009) Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. Disease models & mechanisms. 2(7-8):399-411

Srinivas, B.P., Woo, J., Leong, W.Y., and Roy, S. (2007) A conserved molecular pathway mediates myoblast fusion in insects and vertebrates. Nature Genetics. 39(6):781-786

Veldman, M.B., Bemben, M.A., Thompson, R.C., and Goldman, D. (2007) Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Developmental Biology. 312(2):596-612

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Leskow, F.C., Holloway, B.A., Wang, H., Mullins, M.C., and Kazanietz, M.G. (2006) The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development. Proceedings of the National Academy of Sciences of the United States of America. 103(14):5373-5378

Salas-Vidal, E., Meijer, A.H., Cheng, X., and Spaink, H.P. (2005) Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Genomics. 86(1):25-37

Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (24):

Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

Zebrafish Nomenclature Committee (2022) Nomenclature Data Curation (2022). Nomenclature Committee Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

Zebrafish Nomenclature Committee (2017) Nomenclature Data Curation (2017). Nomenclature Committee Submission.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

Zebrafish Nomenclature Committee (2013) Nomenclature Requests: Mutant and Transgenic Name Reservations (2013). Nomenclature Committee Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.