PUBLICATION
Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System
- Authors
- Zhu, Y., Crowley, S.C., Latimer, A.J., Lewis, G.M., Nash, R., Kucenas, S.
- ID
- ZDB-PUB-190910-2
- Date
- 2019
- Source
- Cell 179(1): 74-89.e10 (Journal)
- Registered Authors
- Kucenas, Sarah, Latimer, Andrew, Nash, Rebecca, Zhu, Yunlu
- Keywords
- interleukin-1β, macrophages, neural crest cells, neural development, neurogenesis, phagocytosis, zebrafish
- Datasets
- GEO:GSE135237
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Apoptosis/physiology
- Cell Differentiation/physiology
- Cell Movement/physiology*
- Interleukin-1beta/metabolism
- Neural Crest/physiology*
- Neurogenesis/physiology*
- Peripheral Nervous System/growth & development*
- Phagocytes/physiology
- Phagocytosis/physiology*
- Phagosomes/physiology
- Spinal Cord/growth & development*
- Zebrafish/embryology
- PubMed
- 31495570 Full text @ Cell
Citation
Zhu, Y., Crowley, S.C., Latimer, A.J., Lewis, G.M., Nash, R., Kucenas, S. (2019) Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System. Cell. 179(1):74-89.e10.
Abstract
During neural tube closure and spinal cord development, many cells die in both the central and peripheral nervous systems (CNS and PNS, respectively). However, myeloid-derived professional phagocytes have not yet colonized the trunk region during early neurogenesis. How apoptotic cells are removed from this region during these stages remains largely unknown. Using live imaging in zebrafish, we demonstrate that neural crest cells (NCCs) respond rapidly to dying cells and phagocytose cellular debris around the neural tube. Additionally, NCCs have the ability to enter the CNS through motor exit point transition zones and clear debris in the spinal cord. Surprisingly, NCCs phagocytosis mechanistically resembles macrophage phagocytosis and their recruitment toward cellular debris is mediated by interleukin-1β. Taken together, our results reveal a role for NCCs in phagocytosis of debris in the developing nervous system before the presence of professional phagocytes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping