Gene
rac1a
- ID
- ZDB-GENE-030131-5415
- Name
- Rac family small GTPase 1a
- Symbol
- rac1a Nomenclature History
- Previous Names
-
- rac1
- wu:fd16e02
- zgc:55823
- zgc:86934
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within cell migration involved in gastrulation; myoblast fusion; and neutrophil chemotaxis. Predicted to be located in lamellipodium; melanosome; and nucleus. Predicted to be active in several cellular components, including cytoplasmic vesicle; cytoskeleton; and plasma membrane. Is expressed in liver; retina; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); lung cancer; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018021Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rac1a | Reijnders et al., 2017 | |
| MO1-rac1a | N/A | (4) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 48 | Alliance | Intellectual developmental disorder, autosomal dominant 48 | 617751 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase Rho | Small GTP-binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q7ZSZ9 | InterPro | 192 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb1:mNeonGreen-rac1a) |
|
| 1 | Shamipour et al., 2019 | |
| Tg(hsp70l:rac1a_T17N-2A-MA-mCherry2) |
| 1 | Swinburne et al., 2018 | ||
| Tg(kop:rac1a_G12V-UTR-nanos3,CMV:EGFP) |
| 1 | (3) | ||
| Tg(mpx:mCherry-2A-rac1a) |
| 1 | (2) | ||
| Tg(UAS:carac1a_G12V-EGFP) |
|
| 1 | Wan et al., 2016 | |
| Tg(UAS:dnrac1a_T17N-EGFP) |
|
| 1 | Wan et al., 2016 | |
| Tg(UAS:rac1a_G12V,cryaa:Cerulean) |
|
| 1 | Hübner et al., 2018 | |
| Tg(UAS:rac1a_G12V-UTR-nanos3,CMV:EGFP) |
| 1 | (4) | ||
| Tg(UAS:rac1a_T17N,cryaa:Cerulean) |
|
| 1 | Hübner et al., 2018 | |
| Tg(UAS:rac1_G12V,cryaa:Cerulean) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-318L24 | ZFIN Curated Data | |
| Encodes | EST | fd16e02 | ||
| Encodes | cDNA | MGC:55823 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55917 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:86934 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199771 (1) | 1805 nt | ||
| Genomic | GenBank:CU633193 (1) | 27874 nt | ||
| Polypeptide | UniProtKB:Q7ZSZ9 (1) | 192 aa |
- Jiang, R.X., Hu, N., Deng, Y.W., Hu, L.W., Gu, H., Luo, N., Wen, J., Jiang, X.Q. (2024) Potential therapeutic role of spermine via Rac1 in osteoporosis: Insights from zebrafish and mice. Zoological research. 45:367380367-380
- Zhou, X., Lian, K., Jia, J., Zhao, X., Duan, P., Huang, J., Shi, Y. (2024) Functions of Epimedin C in a zebrafish model of glucocorticoid-induced osteoporosis. Journal of Cellular and Molecular Medicine. 28:e18569e18569
- Lu, Y., Tang, D., Zheng, Z., Wang, X., Zuo, N., Yan, R., Wu, C., Ma, J., Wang, C., Xu, H., He, Y., Liu, D., Liu, S. (2022) Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Frontiers in molecular neuroscience. 15:844668
- Chiang, K.Y., Li, Y.W., Li, Y.H., Huang, S.J., Wu, C.L., Gong, H.Y., Wu, J.L. (2021) Progranulin A Promotes Compensatory Hepatocyte Proliferation via HGF/c-Met Signaling after Partial Hepatectomy in Zebrafish. International Journal of Molecular Sciences. 22(20):
- Li, Z., Li, B., Wang, J., Lu, Y., Chen, A.F.Y., Sun, K., Yu, Y., Chen, S. (2021) GAA deficiency promotes angiogenesis through upregulation of Rac1 induced by autophagy disorder. Biochimica et biophysica acta. Molecular cell research. 1868(5):118969
- Harris, J.M., Wang, A.Y., Boulanger-Weill, J., Santoriello, C., Foianini, S., Lichtman, J.W., Zon, L.I., Arlotta, P. (2020) Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects. Developmental Cell. 53:577-588.e7
- Klems, A., van Rijssel, J., Ramms, A.S., Wild, R., Hammer, J., Merkel, M., Derenbach, L., Préau, L., Hinkel, R., Suarez-Martinez, I., Schulte-Merker, S., Vidal, R., Sauer, S., Kivelä, R., Alitalo, K., Kupatt, C., van Buul, J.D., le Noble, F. (2020) The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models. Nature communications. 11:5319
- Chen, M., Luo, Y., Xu, J., Chang, M.X., Liu, J.X. (2019) Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival. Frontiers in immunology. 10:2599
- Mikdache, A., Fontenas, L., Albadri, S., Revenu, C., Loisel-Duwattez, J., Lesport, E., Degerny, C., Del Bene, F., Tawk, M. (2019) Elmo1 function, linked to Rac1 activity, regulates peripheral neuronal numbers and myelination in zebrafish. Cellular and molecular life sciences : CMLS. 77(1):161-177
- Shamipour, S., Kardos, R., Xue, S.L., Hof, B., Hannezo, E., Heisenberg, C.P. (2019) Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes. Cell. 177(6):1463-1479.e18
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