Gene
rac1a
- ID
- ZDB-GENE-030131-5415
- Name
- Rac family small GTPase 1a
- Symbol
- rac1a Nomenclature History
- Previous Names
-
- rac1
- wu:fd16e02
- zgc:55823
- zgc:86934
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in cell migration involved in gastrulation; myoblast fusion; and neutrophil chemotaxis. Predicted to localize to several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Is expressed in liver; retina; and retinal ganglion cell layer. Orthologous to human RAC1 (Rac family small GTPase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 48 | Alliance | Intellectual developmental disorder, autosomal dominant 48 | 617751 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase Rho | Small GTP-binding domain |
|---|---|---|---|---|---|
|
UniProtKB:Q7ZSZ9
|
192 |
Interactions and Pathways
No data available
Plasmids