Gene

rac1a

ID
ZDB-GENE-030131-5415
Name
Rac family small GTPase 1a
Symbol
rac1a Nomenclature History
Previous Names
  • rac1
  • wu:fd16e02
  • zgc:55823
  • zgc:86934
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in cell migration involved in gastrulation; myoblast fusion; and neutrophil chemotaxis. Predicted to localize to several cellular components, including cell cortex; cytoplasmic vesicle; and dendritic spine. Is expressed in liver; retina; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rac1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant mental retardation 48 Alliance Mental retardation, autosomal dominant 48 617751
Associated With rac1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005225 Small GTP-binding protein domain
Family IPR001806 Small GTPase
Family IPR003578 Small GTPase Rho
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length P-loop containing nucleoside triphosphate hydrolase Small GTPase Small GTPase Rho Small GTP-binding protein domain
UniProtKB:Q7ZSZ9 192
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-rac1 polyclonal IgG Rabbit
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
3
Ab2-rac1 monoclonal IgG2b Mouse
Millipore
3
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations