header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030131-5415
Gene Name: Rac family small GTPase 1a
Gene Symbol: rac1a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: rac1, wu:fd16e02, zgc:55823, zgc:86934

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in cell migration involved in gastrulation; myoblast fusion; and neutrophil chemotaxis. Predicted to localize to the cell projection; cytoplasmic vesicle; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Is expressed in liver; retina; and retinal ganglion cell layer. Orthologous to human RAC1 (Rac family small GTPase 1).
Genome Resources: Alliance (1),  Gene:327204 (1),  Ensembl(GRCz11):ENSDARG00000074849 (2)
GENE EXPRESSION
All Expression Data: 11 figures from 8 publications
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018021Tg Transgenic Insertion Unknown Unknown DNA
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-rac1a
1
MO1-rac1a N/A 3
PHENOTYPE
Data: 2 figures from 2 publications
Observed in:
DISEASE ASSOCIATED WITH rac1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant mental retardation 48 Alliance Mental retardation, autosomal dominant 48 617751
DISEASE ASSOCIATED WITH rac1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process myoblast fusion (more)
Cellular Component cell cortex (more)
Molecular Function GTPase activity (more)
GO Terms (all 27)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA rac1a-201 (1)    Ensembl 1893
ncRNA rac1a-003 (1)    Ensembl 798
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-rac1 polyclonal IgG Rabbit IHC, WB Santa Cruz Biotechnology, Inc.
3
Ab2-rac1 monoclonal IgG2b Mouse Millipore
3
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM rac1a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(hsp70l:rac1a_T17N-2A-MA-mCherry2) hsp70l 2AMAmCherryrac1a Danio rerio 1 1
Tg(kop:rac1a_G12V-UTR-nanos3,CMV:EGFP) CMVkop EGFPnanos3rac1a Danio rerio 1 2
Tg(mpx:mCherry-2A-rac1a) mpx 2AmCherryrac1a Danio rerio 1 2
tg(uas:carac1a_g12v-egfp) UAS EGFPrac1a Danio rerio 1 1
tg(uas:dnrac1a_t17n-egfp) UAS EGFPrac1a Danio rerio 1 1
Tg(UAS:rac1_G12V,cryaa:Cerulean) cryaaUAS Ceruleanrac1a Danio rerio 1 3
Tg(UAS:rac1_T17N,cryaa:Cerulean) cryaaUAS Ceruleanrac1a Danio rerio 1 3
tg(uas:rac1a_g12v,cryaa:cerulean) cryaaUAS Ceruleanrac1a Danio rerio 1 1
Tg(UAS:rac1a_G12V-UTR-nanos3,CMV:EGFP) CMVUAS EGFPnanos3rac1aUTR Danio rerio 2 3
tg(uas:rac1a_t17n,cryaa:cerulean) cryaaUAS Ceruleanrac1a Danio rerio 1 1
MARKER RELATIONSHIPS
rac1a Contained in: [BAC] CH73-318L24 (1) (order this)
rac1a Encodes: [EST] fd16e02
[cDNA] MGC:55823 (1) (order this), MGC:55917 (1) (order this), MGC:86934 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_199771 (1) 1805 bp
Genomic GenBank:CU633193 (1) 27874 bp
Select Tool
Polypeptide UniProtKB:Q7ZSZ9 (1) 192 aa
Sequence Clusters UniGene:155340 (1)
Sequence Information (all 23)
ORTHOLOGY for rac1a ( Chr: 12 )
CITATIONS (52)