Ablain, J., Xu, M., Rothschild, H., Jordan, R.C., Mito, J.K., Daniels, B.H., Bell, C.F., Joseph, N.M., Wu, H., Bastian, B.C., Zon, L.I., Yeh, I. (2018) Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma.. Science (New York, N.Y.). 362(6418):1055-1060

Blackburn, J.S., Liu, S., Wilder, J.L., Dobrinski, K.P., Lobbardi, R., Moore, F.E., Martinez, S.A., Chen, E.Y., Lee, C., Langenau, D.M. (2014) Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation. Cancer Cell. 25:366-78

Chen, X., Shen, Y., Song, Z., Wang, X., Yao, H., Cai, Y., Zhao, Z., Hu, B. (2024) microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation. Journal of genetics and genomics = Yi chuan xue bao. 51(9):911-921

Choorapoikayil, S., Kuiper, R.V., de Bruin, A., and den Hertog, J. (2012) Haploinsufficiency of tumor suppressor pten predisposes to hemangiosarcoma in zebrafish. Disease models & mechanisms. 5(2):241-247

Ciarlo, C., Kaufman, C.K., Kinikoglu, B., Michael, J., Yang, S., D Amato, C., Blokzijl-Franke, S., den Hertog, J., Schlaeger, T.M., Zhou, Y., Liao, E., Zon, L.I. (2017) A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. eLIFE. 6

Croushore, J.A., Blasiole, B., Riddle, R.C., Thisse, C., Thisse, B., Canfield, V.A., Robertson, G.P., Cheng, K.C., and Levenson, R. (2005) Ptena and ptenb genes play distinct roles in zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 234(4):911-921

Dong, Z.W., Ren, C.G., Xia, Y., Su, D., Du, T.T., Fan, H.B., Yuan, H., Wang, L., Dong, M., Li, W.C., Jin, Y., Chen, Y., Deng, M., Liu, T.X., Gu, A.H., Zhou, Y. (2014) Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. Journal of Hematology & Oncology. 7:17

Feng, N., Bian, Z., Zhang, X., Wang, C., Chen, J. (2018) Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish. Singapore medical journal. 60(5):241-246

Fu, C.T., Zhu, K.Y., Mi, J.Q., Liu, Y.F., Murray, S.T., Fu, Y.F., Ren, C.G., Dong, Z.W., Liu, Y.J., Dong, M., Jin, Y., Chen, Y., Deng, M., Zhang, W., Chen, B., Breslin, P., Chen, S.J., Chen, Z., Becker, M.W., Zhu, J., Zhang, J.W., and Liu, T.X. (2010) An evolutionarily conserved PTEN-C/EBP{alpha}-CTNNA1 axis controls myeloid development and transformation. Blood. 115(23):4715-4724

Gore, A.V., Athans, B., Iben, J.R., Johnson, K., Russanova, V., Castranova, D., Pham, V.N., Butler, M.G., Williams-Simons, L., Nichols, J.T., Bresciani, E., Feldman, B., Kimmel, C.B., Liu, P.P., Weinstein, B.M. (2016) Epigenetic regulation of hematopoiesis by DNA methylation. eLIFE. 5:e11813

Gutierrez, A., Grebliunaite, R., Feng, H., Kozakewich, E., Zhu, S., Guo, F., Payne, E., Mansour, M., Dahlberg, S.E., Neuberg, D.S., Hertog, J.D., Prochownik, E.V., Testa, J.R., Harris, M., Kanki, J.P., and Look, A.T. (2011) Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. The Journal of experimental medicine. 208(8):1595-603

He, S., Zimmerman, M.W., Layden, H.M., Berezovskaya, A., Etchin, J., Martel, M.W., Thurston, G., Jing, C.B., van Rooijen, E., Kaufman, C.K., Rodig, S.J., Zon, L.I., Patton, E.E., Mansour, M.R., Look, A.T. (2021) Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 40(38):5718-5729

Jung, K., Kim, M., So, J., Lee, S.H., Ko, S., Shin, D. (2020) Farnesoid X receptor activation impairs liver progenitor cell-mediated liver regeneration via the PTEN-PI3K-AKT-mTOR axis in zebrafish. Hepatology (Baltimore, Md.). 74(1):397-410

Liu, D., Yu, Y., Schachner, M. (2014) Ptena, but not Ptenb, reduces regeneration after spinal cord injury in adult zebrafish. Experimental neurology. 261:196-205

Lumaquin-Yin, D., Montal, E., Johns, E., Baggiolini, A., Huang, T.H., Ma, Y., LaPlante, C., Suresh, S., Studer, L., White, R.M. (2023) Lipid droplets are a metabolic vulnerability in melanoma. Nature communications. 14:31923192

Mathews, E.S., Appel, B. (2016) Cholesterol Biosynthesis Supports Myelin Gene Expression and Axon Ensheathment through Modulation of P13K/Akt/mTor Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:7628-39

Overman, J.P., and den Hertog, J. (2014) Zebrafish as a model to study PTPs during development. Methods (San Diego, Calif.). 65(2):247-53

Qu, X., Liao, M., Liu, W., Cai, Y., Yi, Q., Long, J., Tan, L., Deng, Y., Deng, H., Chen, X. (2021) Loss of Wnt16 Leads to Skeletal Deformities and Downregulation of Bone Developmental Pathway in Zebrafish. International Journal of Molecular Sciences. 22(13):

Stumpf, M., Blokzijl-Franke, S., den Hertog, J. (2016) Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis. PLoS One. 11:e0154771

Suresh, S., Rabbie, R., Garg, M., Lumaquin, D., Huang, T.H., Montal, E., Ma, Y., Cruz, N.M., Tang, X., Nsengimana, J., Newton-Bishop, J., Hunter, M.V., Zhu, Y., Chen, K., de Stanchina, E., Adams, D.J., White, R.M. (2022) Identifying the transcriptional drivers of metastasis embedded within localized melanoma. Cancer discovery. 13(1):194-215

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Wild, R., Klems, A., Takamiya, M., Hayashi, Y., Strähle, U., Ando, K., Mochizuki, N., van Impel, A., Schulte-Merker, S., Krueger, J., Preau, L., le Noble, F. (2017) Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Nature communications. 8:13991

Zhang, L., Liu, C., Zhou, X., Xie, Y., Su, L., Geng, Q., Liu, B., Liu, S. (2016) Transgenic overexpression of BAFF regulates the expression of immune-related genes in zebrafish, Danio rerio. Journal of genetics. 95:751-760

Zhao, W., Cao, L., Ying, H., Zhang, W., Li, D., Zhu, X., Xue, W., Wu, S., Cao, M., Fu, C., Qi, H., Hao, Y., Tang, Y.C., Qin, J., Zhong, T.P., Lin, X., Yu, L., Li, X., Li, L., Wu, D., Pan, W. (2019) Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Research. 29(11):895-910

Chen, X., Shen, Y., Song, Z., Wang, X., Yao, H., Cai, Y., Zhao, Z., Hu, B. (2024) microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation. Journal of genetics and genomics = Yi chuan xue bao. 51(9):911-921

Tagore, M., Hergenreder, E., Perlee, S.C., Cruz, N.M., Menocal, L., Suresh, S., Chan, E., Baron, M., Melendez, S., Dave, A., Chatila, W.K., Nsengimana, J., Koche, R.P., Hollmann, T.J., Ideker, T., Studer, L., Schietinger, A., White, R.M. (2023) GABA regulates electrical activity and tumor initiation in melanoma. Cancer discovery. 13(10):2270-2291

Suresh, S., Rabbie, R., Garg, M., Lumaquin, D., Huang, T.H., Montal, E., Ma, Y., Cruz, N.M., Tang, X., Nsengimana, J., Newton-Bishop, J., Hunter, M.V., Zhu, Y., Chen, K., de Stanchina, E., Adams, D.J., White, R.M. (2022) Identifying the transcriptional drivers of metastasis embedded within localized melanoma. Cancer discovery. 13(1):194-215

Blokzijl-Franke, S., Ponsioen, B., Schulte-Merker, S., Herbomel, P., Kissa, K., Choorapoikayil, S., den Hertog, J. (2021) Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells. Oncogene. 40(15):2741-2755

Luo, J., Lu, C., Feng, M., Dai, L., Wang, M., Qiu, Y., Zheng, H., Liu, Y., Li, L., Tang, B., Xu, C., Wang, Y., Yang, X. (2021) Cooperation between liver-specific mutations of pten and tp53 genetically induces hepatocarcinogenesis in zebrafish. Journal of experimental & clinical cancer research : CR. 40:262

Ding, Y., Wang, W., Ma, D., Liang, G., Kang, Z., Xue, Y., Zhang, Y., Wang, L., Heng, J., Zhang, Y., Liu, F. (2020) Smarca5 mediated epigenetic programming facilitates fetal HSPC development in vertebrates. Blood. 137(2):190-202

Lei, Z., Klasson, T.D., Brandt, M.M., van de Hoek, G., Logister, I., Cheng, C., Doevendans, P.A., Sluijter, J.P.G., Giles, R.H. (2020) Control of Angiogenesis via a VHL/miR-212/132 Axis. Cells. 9(4):

Pereiro, P., Figueras, A., Novoa, B. (2020) Zebrafish pten Genes Play Relevant but Distinct Roles in Antiviral Immunity. Vaccines. 8(2):

Zhao, W., Cao, L., Ying, H., Zhang, W., Li, D., Zhu, X., Xue, W., Wu, S., Cao, M., Fu, C., Qi, H., Hao, Y., Tang, Y.C., Qin, J., Zhong, T.P., Lin, X., Yu, L., Li, X., Li, L., Wu, D., Pan, W. (2019) Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Research. 29(11):895-910

Feng, N., Bian, Z., Zhang, X., Wang, C., Chen, J. (2018) Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish. Singapore medical journal. 60(5):241-246

Hale, A.J., Kiai, A., Sikkens, J., den Hertog, J. (2017) Impaired caudal fin-fold regeneration in zebrafish deficient for the tumor suppressor Pten. Regeneration (Oxford, England). 4:217-226

Wild, R., Klems, A., Takamiya, M., Hayashi, Y., Strähle, U., Ando, K., Mochizuki, N., van Impel, A., Schulte-Merker, S., Krueger, J., Preau, L., le Noble, F. (2017) Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Nature communications. 8:13991

Gore, A.V., Athans, B., Iben, J.R., Johnson, K., Russanova, V., Castranova, D., Pham, V.N., Butler, M.G., Williams-Simons, L., Nichols, J.T., Bresciani, E., Feldman, B., Kimmel, C.B., Liu, P.P., Weinstein, B.M. (2016) Epigenetic regulation of hematopoiesis by DNA methylation. eLIFE. 5:e11813

Stumpf, M., Blokzijl-Franke, S., den Hertog, J. (2016) Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis. PLoS One. 11:e0154771

Zhang, L., Liu, C., Zhou, X., Xie, Y., Su, L., Geng, Q., Liu, B., Liu, S. (2016) Transgenic overexpression of BAFF regulates the expression of immune-related genes in zebrafish, Danio rerio. Journal of genetics. 95:751-760

Choorapoikayil, S., Kers, R., Herbomel, P., Kissa, K., and den Hertog, J. (2014) Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish. Blood.

Liu, D., Yu, Y., Schachner, M. (2014) Ptena, but not Ptenb, reduces regeneration after spinal cord injury in adult zebrafish. Experimental neurology. 261:196-205

Choorapoikayil, S., Weijts, B., Kers, R., de Bruin, A., and den Hertog, J. (2013) Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish. Disease models & mechanisms. 6(5):1159-66

McCarthy, N., Wetherill, L., Lovely, C.B., Swartz, M.E., Foroud, T.M., and Eberhart, J.K. (2013) Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. Development (Cambridge, England). 140(15):3254-3265

Yen, J., White, R.M., Wedge, D.C., Van Loo, P., de Ridder, J., Capper, A., Richardson, J., Jones, D., Raine, K., Watson, I.R., Wu, C.J., Cheng, J., Martincorena, I., Nik-Zainal, S., Mudie, L., Moreau, Y., Marshall, J., Ramakrishna, M., Tarpey, P., Shlien, A., Whitmore, I., Gamble, S., Latimer, C., Langdon, E., Kaufman, C., Dovey, M., Taylor, A., Menzies, A., McLaren, S., O Meara, S., Butler, A., Teague, J., Lister, J., Chin, L., Campbell, P., Adams, D.J., Zon, L.I., Patton, E.E., Stemple, D.L., and Futreal, P.A. (2013) The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome biology. 14(10):R113

Gutierrez, A., Grebliunaite, R., Feng, H., Kozakewich, E., Zhu, S., Guo, F., Payne, E., Mansour, M., Dahlberg, S.E., Neuberg, D.S., Hertog, J.D., Prochownik, E.V., Testa, J.R., Harris, M., Kanki, J.P., and Look, A.T. (2011) Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. The Journal of experimental medicine. 208(8):1595-603

Finkielsztein, A., and Kelly, G.M. (2009) Altering PI3K—Akt signalling in zebrafish embryos affects PTEN phosphorylation and gastrulation. Biology of the cell. 101(11):661–682

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903