ZFIN ID: ZDB-GENE-020424-1
CITATIONS (43 total)
Gene Name: metal-regulatory transcription factor 1
Gene Symbol: mtf1
Ferlazzo, G.M., Gambetta, A.M., Amato, S., Cannizzaro, N., Angiolillo, S., Arboit, M., Diamante, L., Carbognin, E., Romani, P., La Torre, F., Galimberti, E., Pflug, F., Luoni, M., Giannelli, S., Pepe, G., Capocci, L., Di Pardo, A., Vanzani, P., Zennaro, L., Broccoli, V., Leeb, M., Moro, E., Maglione, V., Martello, G. (2023) Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity. Nature communications. 14:39623962
Wu, Y., Liu, W., Li, L., Tai, Z., Liu, J.X. (2023) Transcriptional profiles in zebrafish atp7a mutants and responses of atp7a mutants to Cu stress. Water Biology and Security. Volume 2, Issue 3
Yang, S., Xu, X., Zhang, A., Wang, Y., Ji, G., Sun, C., Li, H. (2023) The evolution and immunomodulatory role of Zc3h12 proteins in zebrafish (Danio rerio). International journal of biological macromolecules. 239:124214
Aksakal, F.I., Ciltas, A. (2019) Impact of copper oxide nanoparticles (CuO NPs) exposure on embryo development and expression of genes related to the innate immune system of zebrafish (Danio rerio). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 223:78-87
Icoglu Aksakal, F., Ciltas, A., Simsek Ozek, N. (2019) A holistic study on potential toxic effects of carboxylated multi-walled carbon nanotubes (MWCNTs-COOH) on zebrafish (Danio rerio) embryos/larvae. Chemosphere. 225:820-828
Wang, C.C., Si, L.F., Guo, S.N., Zheng, J.L. (2019) Negative effects of acute cadmium on stress defense, immunity, and metal homeostasis in liver of zebrafish: The protective role of environmental zinc dpre-exposure. Chemosphere. 222:91-97
Cosse-Etchepare, C., Gervi, I., Buisson, I., Formery, L., Schubert, M., Riou, J.F., Umbhauer, M., Le Bouffant, R. (2018) Pou3f transcription factor expression during embryonic development highlights distinct pou3f3 and pou3f4 localization in the Xenopus laevis kidney. The International journal of developmental biology. 62:325-333
Zhu, Q.L., Li, W.Y., Zheng, J.L. (2018) Life-cycle exposure to cadmium induced compensatory responses towards oxidative stress in the liver of female zebrafish. Chemosphere. 210:949-957
Beaver, L.M., Nkrumah-Elie, Y.M., Truong, L., Barton, C.L., Knecht, A.L., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model. The Journal of Nutritional Biochemistry. 43:78-87
Beaver, L.M., Truong, L., Barton, C.L., Chase, T.T., Gonnerman, G.D., Wong, C.P., Tanguay, R.L., Ho, E. (2017) Combinatorial effects of zinc deficiency and arsenic exposure on zebrafish (Danio rerio) development. PLoS One. 12:e0183831
Lin, S.J., Chiang, M.C., Shih, H.Y., Chiang, K.C., Cheng, Y.C. (2017) Spatiotemporal expression of foxo4, foxo6a, and foxo6b in the developing brain and retina are transcriptionally regulated by PI3K signaling in zebrafish. Development genes and evolution. 227(3):219-230
Macirella, R., Brunelli, E. (2017) Morphofunctional Alterations in Zebrafish (Danio rerio) Gills after Exposure to Mercury Chloride. International Journal of Molecular Sciences. 18(4)
Pradhan, A., Ivarsson, P., Ragnvaldsson, D., Berg, H., Jass, J., Olsson, P.E. (2017) Transcriptional responses of zebrafish to complex metal mixtures in laboratory studies overestimates the responses observed with environmental water. The Science of the total environment. 584-585:1138-1146
Zhao, S.J., Guo, S.N., Zhu, Q.L., Yuan, S.S., Zheng, J.L. (2017) Heat-induced oxidative stress and inflammation involve in cadmium pollution history in the spleen of zebrafish. Fish & shellfish immunology. 72:1-8
Zhu, Q.L., Guo, S.N., Yuan, S.S., Lv, Z.M., Zheng, J.L., Xia, H. (2017) Heat indicators of oxidative stress, inflammation and metal transport show dependence of cadmium pollution history in the liver of female zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 191:1-9
Krishnaraj, C., Harper, S.L., Yun, S.I. (2016) In Vivo toxicological assessment of biologically synthesized silver nanoparticles in adult Zebrafish (Danio rerio). Journal of hazardous materials. 301:480-491
Macirella, R., Guardia, A., Pellegrino, D., Bernabò, I., Tronci, V., Ebbesson, L.O., Sesti, S., Tripepi, S., Brunelli, E. (2016) Effects of Two Sublethal Concentrations of Mercury Chloride on the Morphology and Metallothionein Activity in the Liver of Zebrafish (Danio rerio). International Journal of Molecular Sciences. 17(3):361
Pradhan, A., Olsson, P.E. (2015) Zebrafish sexual behavior: role of sex steroid hormones and prostaglandins. Behavioral and brain functions : BBF. 11:23
O'Shields, B., McArthur, A.G., Holowiecki, A., Kamper, M., Tapley, J., Jenny, M.J. (2014) Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development. Biochimica et biophysica acta. Molecular cell research. 1843(9):1818-33
Zheng, D., Feeney, G.P., Handy, R.D., Hogstrand, C., and Kille, P. (2014) Uptake epithelia behave in a cell-centric and not systems homeostatic manner in response to zinc depletion and supplementation. Metallomics : integrated biometal science. 6(1):154-65
Tang, S., Allagadda, V., Chibli, H., Nadeau, J.L., and Mayer, G.D. (2013) Comparison of cytotoxicity and expression of metal regulatory genes in zebrafish (Danio rerio) liver cells exposed to cadmium sulfate, zinc sulfate and quantum dots. Metallomics : integrated biometal science. 5(10):1411-22
Urbatzka, R., Rocha, E., Reis, B., Cruzeiro, C., Monteiro, R.A., and Rocha, M.J. (2012) Effects of ethinylestradiol and of an environmentally relevant mixture of xenoestrogens on steroidogenic gene expression and specific transcription factors in zebrafish. Environmental pollution (Barking, Essex : 1987). 164C:28-35
Hong, S.K., Levin, C.S., Brown, J.L., Wan, H., Sherman, B.T., Huang, D.W., Lempicki, R.A., and Feldman, B. (2010) Pre-gastrula expression of zebrafish extraembryonic genes. BMC Developmental Biology. 10:42
Cheuk, W.K., Chan, P.C., and Chan, K.M. (2008) Cytotoxicities and induction of metallothionein (MT) and metal regulatory element (MRE)-binding transcription factor-1 (MTF-1) messenger RNA levels in the zebrafish (Danio rerio) ZFL and SJD cell lines after exposure to various metal ions. Aquatic toxicology (Amsterdam, Netherlands). 89(2):103-112
Hogstrand, C., Zheng, D., Feeney, G., Cunningham, P., and Kille, P. (2008) Zinc-controlled gene expression by metal-regulatory transcription factor 1 (MTF1) in a model vertebrate, the zebrafish. Biochemical Society transactions. 36(6):1252-1257
Chen, W.Y., John, J.A., Lin, C.H., and Chang, C.Y. (2007) Expression pattern of metallothionein, MTF-1 nuclear translocation, and its dna-binding activity in zebrafish (Danio rerio) induced by zinc and cadmium. Environmental toxicology and chemistry. 26(1):110-117
Griffitt, R.J., Weil, R., Hyndman, K.A., Denslow, N.D., Powers, K., Taylor, D., and Barber, D.S. (2007) Exposure to copper nanoparticles causes gill injury and acute lethality in zebrafish (Danio rerio). Environmental science & technology. 41(23):8178-8186
Chen, W.-Y., John, A.C.J., Lin, C.-H., and Chang, C.-Y. (2002) Molecular cloning and developmental expression of zinc finger transcription factor MTF-1 gene in zebrafish, Danio rerio. Biochemical and Biophysical Research Communications. 291(4):798-805
Dalton, T.P., Solis, W.A., Nebert, D.W., and Carvan, M.J., III (2000) Characterization of the MTF-1 transcription factor from zebrafish and trout cells. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 126(3):325-335
Additional Citations (14):
ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.
ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.
ZFIN Staff (2003) Curation of orthology data. Manually curated data.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
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