ZFIN

ZFIN ID: ZDB-GENE-000616-13

ZFIN ID: ZDB-GENE-000616-13

CITATIONS (65 total)

Gene Name:	amyloid beta (A4) precursor protein a
Gene Symbol:	appa

Nazli, D., Ipekgil, D., Poyraz, Y.K., Can, K., Okmen, I., Turhanlar-Sahin, E., Sert Serdar, B., Kocturk, S., Ozhan, G. (2026) Epigallocatechin Gallate and Punicalagin Combination Reduces Aβ Aggregation and Promotes Neurogenesis in Adult Zebrafish Brain. Journal of neuroscience research. 104:e70119e70119

Dharshan, S.S., R, M., Rao, S.M., Aswinanand, B., Ramamurthy, K., Muthuramamoorthy, M., Arasu, M.V., Kumaradoss, K.M., Guru, A., Palaniappan, S., Arockiaraj, J. (2025) SG06, a Chalcone Derivative Targets PI3K/AKT1 Pathway for Neuroprotection and Cognitive Enhancement in an Alzheimer's Disease-Like Zebrafish Model. Molecular neurobiology. :

Kroll, F., Donnelly, J., Özcan, G.G., Mackay, E., Rihel, J. (2025) Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer's disease risk genes. eLIFE. 13:

Dhiman, N., Deshwal, S., Rishi, V., Singhal, N., Sandhir, R. (2024) Zebrafish as a model organism to study sporadic Alzheimer's disease: Behavioural, biochemical and histological validation. Experimental neurology. 383:115034

Rahmati, M., Chebli, J., Banote, R.K., Roselli, S., Agholme, L., Zetterberg, H., Abramsson, A. (2024) Fine-tuning amyloid precursor protein expression through nonsense mediated mRNA decay. eNeuro. 11(6):

Özcan, G.G., Lim, S., Canning, T., Tirathdas, L., Donnelly, J., Kundu, T., Rihel, J. (2024) Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance. iScience. 27:108870108870

Park, J., Kim, D.Y., Hwang, G.S., Han, I.O. (2023) Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer's disease neuropathology in adult zebrafish. Journal of neuroinflammation. 20:257257

Siddiqui, A., Abidin, S.A.Z., Shah, Z.A., Othman, I., Kumari, Y. (2023) Behavioural, genomics and proteomic approach to examine Alzheimer's disease in zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 271:109636

Capriello, T., Monteiro, S.M., Félix, L.M., Donizetti, A., Aliperti, V., Ferrandino, I. (2021) Apoptosis, oxidative stress and genotoxicity in developing zebrafish after aluminium exposure. Aquatic toxicology (Amsterdam, Netherlands). 236:105872

Chebli, J., Rahmati, M., Lashley, T., Edeman, B., Oldfors, A., Zetterberg, H., Abramsson, A. (2021) The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish. Scientific Reports. 11:19115

Banote, R.K., Chebli, J., Şatır, T.M., Varshney, G.K., Camacho, R., Ledin, J., Burgess, S.M., Abramsson, A., Zetterberg, H. (2020) Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish. Scientific Reports. 10:10127

Barthelson, K., Pederson, S.M., Newman, M., Lardelli, M. (2020) Brain Transcriptome Analysis of a Protein-Truncating Mutation in Sortilin-Related Receptor 1 Associated With Early-Onset Familial Alzheimer's Disease Indicates Early Effects on Mitochondrial and Ribosome Function. Journal of Alzheimer's disease : JAD. 79(3):1105-1119

Kanyo, R., Leighton, P.L.A., Neil, G.J., Locskai, L.F., Allison, W.T. (2020) Amyloid-β precursor protein mutant zebrafish exhibit seizure susceptibility that depends on prion protein. Experimental neurology. 328:113283

Sharma, C., Kang, S.C. (2020) Garcinol pacifies acrylamide induced cognitive impairments, neuroinflammation and neuronal apoptosis by modulating GSK signaling and activation of pCREB by regulating cathepsin B in the brain of zebrafish larvae. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 138:111246

Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26

Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5

Lee, J., Peterson, S.M., Freeman, J.L. (2017) Sex-specific characterization and evaluation of the Alzheimer's disease genetic risk factor sorl1 in zebrafish during aging and in the adult brain following a 100 ppb embryonic lead exposure. Journal of applied toxicology : JAT. 37(4):400-407

Lim, F.T., Lim, S.M., Ramasamy, K. (2017) Cholesterol lowering by Pediococcus acidilactici LAB4 and Lactobacillus plantarum LAB12 in adult zebrafish is associated with improved memory and involves an interplay between npc1l1 and abca1. Food & function. 8(8):2817-2828

Tu, H., Peng, T., Liu, J., Chen, X., Fan, C., Huang, Z., Zhang, Y., Zou, F., Meng, X. (2017) Role of neurexin2a in lead-induced locomotor defect in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 194:167-175

Lee, J., Freeman, J.L. (2016) Embryonic exposure to 10 μg L(-1) lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer's disease in aged adult zebrafish brain. Metallomics : integrated biometal science. 8(6):589-96

Lee, J., Peterson, S.M., Freeman, J.L. (2016) Alzheimer's disease risk genes in wild-type adult zebrafish exhibit gender-specific expression changes during aging. Neurogenetics. 17(3):197-9

Jung, I.H., Choi, J.H., Chung, Y.Y., Lim, G.L., Park, Y.N., Park, S.W. (2015) Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis. Neoplasia (New York, N.Y.). 17:586-97

Moussavi-Nik, S.H., Newman, M., Wilson, L., Ebrahimie, E., Wells, S., Musgrave, I., Verdile, G., Martins, R.N., Lardelli, M. (2015) Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity. Human molecular genetics. 24(13):3662-78

Hiolski, E.M., Kendrick, P.S., Frame, E.R., Myers, M.S., Bammler, T.K., Beyer, R.P., Farin, F.M., Wilkerson, H.W., Smith, D.R., Marcinek, D.J., Lefebvre, K.A. (2014) Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS. Aquatic toxicology (Amsterdam, Netherlands). 155C:151-159

Newman, M., Wilson, L., Verdile, G., Lim, A., Khan, I., Moussavi Nik, S.H., Pursglove, S., Chapman, G., Martins, R.N., and Lardelli, M. (2014) Differential, dominant activation and inhibition of Notch signalling and APP cleavage by truncations of PSEN1 in human disease. Human molecular genetics. 23(3):602-17

Nicolas, M., Hassan, B.A. (2014) Amyloid precursor protein and neural development. Development (Cambridge, England). 141:2543-8

Fleisch, V.C., Leighton, P.L., Wang, H., Pillay, L.M., Ritzel, R.G., Bhinder, G., Roy, B., Tierney, K.B., Ali, D.W., Waskiewicz, A.J., and Allison, W.T. (2013) Targeted Mutation of the Gene Encoding Prion Protein in Zebrafish reveals a Conserved Role in Neuron Excitability. Neurobiology of disease. 55:11-25

Luna, S., Cameron, D.J., and Ethell, D.W. (2013) Amyloid-beta and APP Deficiencies Cause Severe Cerebrovascular Defects: Important Work for an Old Villain. PLoS One. 8(9):e75052

Wilson, L., and Lardelli, M. (2013) The Development of an in vivo gamma-Secretase Assay using Zebrafish Embryos. Journal of Alzheimer's disease : JAD. 36(3):521-34

Yang, H., Zhou, Y., Gu, J., Xie, S., Xu, Y., Zhu, G., Wang, L., Huang, J., Ma, H., and Yao, J. (2013) Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae. PLoS One. 8(5):e64058

Kaiser, D.M., Acharya, M., Leighton, P.L., Wang, H., Daude, N., Wohlgemuth, S., Shi, B., and Allison, W.T. (2012) Amyloid Beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development. PLoS One. 7(12):e51305

Liao, H.K., Wang, Y., Watt, K.E., Wen, Q., Breitback, J., Kemmet, C.K., Clark, K.J., Ekker, S.C., Essner, J.J., and McGrail, M. (2012) Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(2):415-425

Nik, S.H., Wilson, L., Newman, M., Croft, K., Mori, T.A., Musgrave, I., and Lardelli, M. (2012) The BACE1-PSEN-AbetaPP Regulatory Axis has an Ancient Role in Response to Low Oxygen/Oxidative Stress. Journal of Alzheimer's disease : JAD. 28(3):515-530

Song, P., and Pimplikar, S.W. (2012) Knockdown of amyloid precursor protein in zebrafish causes defects in motor axon outgrowth. PLoS One. 7(4):e34209

Charoensawan, V., Adryan, B., Martin, S., Söllner, C., Thisse, B., Thisse, C., Wright, G.J., and Teichmann, S.A. (2010) The Impact of Gene Expression Regulation on Evolution of Extracellular Signaling Pathways. Molecular & cellular proteomics : MCP. 9(12):2666-2677

Martin, S., Söllner, C., Charoensawan, V., Adryan, B., Thisse, B., Thisse, C., Teichmann, S.A., and Wright, G.J. (2010) Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Molecular & cellular proteomics : MCP. 9(12):2654-2665

Joshi, P., Liang, J.O., Dimonte, K., Sullivan, J., and Pimplikar, S.W. (2009) Amyloid precursor protein is required for convergent-extension movements during Zebrafish development. Developmental Biology. 335(1):1-11

Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314

Stickney, H.L., Schmutz, J., Woods, I.G., Holtzer, C.C., Dickson, M.C., Kelly, P.D., Myers, R.M., and Talbot, W.S. (2002) Rapid mapping of zebrafish mutations with SNPs and oligonucleotide microarrays. Genome research. 12(12):1929-1934

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Musa, A., Lehrach, H., and Russo, V.E.A. (2001) Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development. Development genes and evolution. 211(11):563-567

Additional Citations (24):

Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

China Zebrafish Resource Center (CZRC) (2017) CZRC Zebrafish Chromosome 1 All-gene Knockout Project (ZKO project) mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Curation of unpublished nucleotide sequence accession numbers. Manually curated data.

ZFIN Staff (2003) Computational Sequence to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.