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Phenotype Figure Summary
Marker:
pmm2
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Klaver
et al.
, 2021
Figure 1
pmm2
sa10150/sa10150
ceratohyal cartilage chondrocyte disorganized, abnormal
ceratohyal cartilage deformed, abnormal
fin
pmm2
expression decreased amount, abnormal
Meckel's cartilage chondrocyte disorganized, abnormal
Meckel's cartilage shortened, abnormal
phosphomannomutase activity decreased process quality, abnormal
Figure 2
pmm2
sa10150/sa10150
motor neuron postsynaptic density immature, abnormal
swimming behavior decreased process quality, abnormal
whole organism dead, abnormal
Figure 3
pmm2
sa10150/sa10150
chondrocyte Ab11-cdh2 labeling spatial pattern, abnormal
chondrocyte Ab19-ctnnb labeling spatial pattern, abnormal
chondrocyte nucleus displaced to chondrocyte membrane, abnormal
chondrocyte regulation of establishment of planar polarity decreased process quality, abnormal
protein maturation decreased process quality, abnormal
Figure 4
pmm2
sa10150/sa10150
regulation of protein processing increased process quality, abnormal
whole organism Ab1-furin labeling increased amount, abnormal
whole organism Ab3-mmp9 labeling increased amount, abnormal
whole organism Ab3-mmp9 labeling spatial pattern, abnormal
whole organism Ab4-mmp2 labeling spatial pattern, abnormal
Figure 5
pmm2
sa10150/sa10150
; y1Tg/y1Tg
Meckel's cartilage chondrocyte vacuolated, abnormal
Meckel's cartilage convergent extension involved in organogenesis decreased process quality, abnormal
Figure 7
pmm2
sa10150/sa10150
whole organism protein N-linked glycosylation decreased process quality, abnormal
Mukaigasa
et al.
, 2018
Fig. 1
pmm2
it768/it768
gill
gstp1.2
expression increased amount, abnormal
liver
hmox1a
expression increased amount, abnormal
Fig. 2
pmm2
it768/it768
whole organism decreased life span, abnormal
whole organism protein N-linked glycosylation decreased process quality, abnormal
whole organism viability, abnormal
Fig. 3
WT + MO3-pmm2
, 
pmm2
it768/it768
gill
gstp1.2
expression increased amount, abnormal
liver
hspa5
expression increased amount, abnormal
response to endoplasmic reticulum stress increased occurrence, abnormal
whole organism
ddit3
expression increased amount, abnormal
whole organism
hspa5
expression increased amount, abnormal
Fig. 4
pmm2
it768/it768
liver
hspa5
expression increased amount, abnormal
response to endoplasmic reticulum stress increased occurrence, abnormal
Fig. S1
pmm2
it768/it768
gill
gstp1.2
expression increased amount, abnormal
Fig. S4
pmm2
it768/it768
gill
pmm2
expression increased amount, abnormal
liver
pmm2
expression increased amount, abnormal
Fig. S7
pmm2
it768/it768
liver
hspa5
expression increased amount, abnormal
response to endoplasmic reticulum stress increased occurrence, abnormal
Cline
et al.
, 2012
Fig. 2
WT + MO2-pmm2
cartilage morphogenesis disrupted, abnormal
ceratohyal cartilage morphology, abnormal
Meckel's cartilage decreased distance ceratohyal cartilage, abnormal
Meckel's cartilage morphology, abnormal
palatoquadrate cartilage decreased length, abnormal
palatoquadrate cartilage shape, abnormal
pectoral fin kinked, abnormal
Fig. 3
WT + MO2-pmm2
swimming behavior decreased process quality, abnormal
thigmotaxis decreased process quality, abnormal
whole organism circling, abnormal
Fig. 4
ml2Tg + MO2-pmm2
spinal cord secondary motor neuron increased amount, abnormal
Fig. 5
WT + MO2-pmm2
lipooligosaccharide catabolic process increased occurrence, abnormal
protein N-linked glycosylation decreased occurrence, abnormal
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