FIGURE

Fig. 4

ID

ZDB-FIG-180627-51

Publication

Mukaigasa et al., 2018 - Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish

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Fig. 4

The Nrf2-dependent attenuation of the up-regulated ER stress by sulforaphane treatment. The graphs show the percentages of bip-positive 5-dpf larvae of the indicated genotypes and their expression after 12-h treatment of 40 ?M sulforaphane (SF). The numbers of larvae tested are indicated above the bars. An asterisk denotes statistical significance (Fisher?s exact test; *P < 0.001). The data were obtained based on the results of the WISH analysis shown in the Right panels. The strength of the bip staining was determined by double-blind scoring. The arrowheads indicate the liver.

Expression Data

Gene:	hspa5
Fish:	pmm2^it768/it768 nfe2l2a^fh318/fh318; pmm2^it768/it768
Condition:	chemical treatment: sulforaphane
Anatomical Term:	liver
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pmm2^it768/it768 nfe2l2a^fh318/fh318; pmm2^it768/it768
Condition:	chemical treatment: sulforaphane
Observed In:	liver response to endoplasmic reticulum stress
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA