Publication	Data		Fish	Anatomy
Zareba et al., 2024	Fig. 1		zh901Tg/zh901Tg + CRISPR6-npc1 + CRISPR7-npc1 + CRISPR8-npc1 ,   i149Tg/i149Tg; i186Tg/i186Tg + CRISPR6-npc1 + CRISPR7-npc1 + CRISPR8-npc1	microglial cell cell projection decreased amount, abnormal optic tectum microglial cell circular, abnormal optic tectum microglial cell mCherry expression spatial pattern, abnormal
	Fig. 2		i149Tg/i149Tg; i186Tg/i186Tg + CRISPR6-npc1 + CRISPR7-npc1 + CRISPR8-npc1	hindbrain microglial cell mCherry expression spatial pattern, abnormal optic tectum microglial cell vacuolated, abnormal optic tectum phagocytic vesicle increased size, abnormal
	Fig. 3		i149Tg/i149Tg; i186Tg/i186Tg + CRISPR6-npc1 + CRISPR7-npc1 + CRISPR8-npc1	microglial cell cholesterol storage increased occurrence, abnormal microglial cell ganglioside galactosyltransferase activity increased occurrence, abnormal optic tectum microglial cell vacuolated, abnormal optic tectum phagocytic vesicle increased size, abnormal
	Fig. 6		i149Tg/i149Tg; i186Tg/i186Tg + CRISPR6-npc1 + CRISPR7-npc1 + CRISPR8-npc1	optic tectum microglial cell circular, abnormal optic tectum microglial cell vacuolated, abnormal
Quelle-Regaldie et al., 2023	Figure 11		npc1zf3970/zf3970 (AB)	whole organism cholesteryl ester decreased amount, abnormal whole organism phosphatidate(2-) decreased amount, abnormal whole organism phosphatidylglycerol increased amount, abnormal whole organism phosphatidylinositol increased amount, abnormal whole organism sphingomyelin increased amount, abnormal
	Figure 13		npc1zf3970/zf3970 (AB)	whole organism N-heptadecanoyl-15-methylhexadecasphingosine-1-phosphocholine increased amount, abnormal
	Figure 2		npc1zf3971/zf3971 (AB) ,   npc1zf3970/zf3970 (AB)	whole organism dead, abnormal whole organism viability, abnormal
	Figure 3		npc1zf3971/zf3971 (AB) ,   npc1zf3970/zf3970 (AB)	whole organism decreased length, abnormal
	Figure 4		npc1zf3971/zf3971 (AB) ,   npc1zf3970/zf3970 (AB)	hepatocyte lipid increased amount, abnormal hepatocyte vacuole increased amount, abnormal
	Figure 5		npc1zf3971/zf3971 (AB) ,   npc1zf3970/zf3970 (AB)	enterocyte lipid increased amount, abnormal enterocyte vacuole increased amount, abnormal grey matter lipid increased amount, abnormal grey matter vacuole increased amount, abnormal hepatocyte lipid increased amount, abnormal hepatocyte vacuole increased amount, abnormal renal tubule lipid increased amount, abnormal renal tubule vacuole increased amount, abnormal
	Figure 6		npc1zf3971/zf3971 (AB) ,   npc1zf3970/zf3970 (AB)	central nervous system Ab2-npc1 labeling absent, abnormal intestine Ab2-npc1 labeling absent, abnormal liver Ab2-npc1 labeling absent, abnormal renal tubule Ab2-npc1 labeling absent, abnormal
	Figure 7		npc1zf3971/zf3971 (AB) ,   npc1zf3970/zf3970 (AB)	intestine cholesterol increased amount, abnormal intestine sphingomyelin increased amount, abnormal liver cholesterol increased amount, abnormal liver sphingomyelin increased amount, abnormal
	Figure 8		npc1zf3971/zf3971 (AB) ,   npc1zf3970/zf3970 (AB)	swimming behavior decreased process quality, abnormal
Tseng et al., 2021	Fig. S11		npc1hg37/hg37 (EKW)	blood circulation disrupted, abnormal brain decreased size, abnormal head decreased size, abnormal hindbrain decreased size, abnormal otolith absent, abnormal post-vent region curved dorsal, abnormal post-vent region curved lateral, abnormal post-vent region curved ventral, abnormal post-vent region kinked, abnormal
Cook et al., 2020	Fig. 1		AB/TL + MO1-npc1	whole organism motor behavior decreased process quality, abnormal
	Fig. 3		AB/TL + MO1-npc1	cerebellum cholesterol increased amount, abnormal forebrain cholesterol increased amount, abnormal hindbrain cholesterol increased amount, abnormal midbrain cholesterol increased amount, abnormal
	Fig. 4		AB/TL + MO1-npc1	cerebellum ganglioside GM1 increased amount, abnormal forebrain ganglioside GM1 increased amount, abnormal hindbrain ganglioside GM1 increased amount, abnormal midbrain ganglioside GM1 increased amount, abnormal
Liao et al., 2018	Fig. 5		WT + MO1-npc1	hatching decreased rate, abnormal whole organism cholesterol increased amount, abnormal
Lin et al., 2018	Fig. 2		npc1ihb335/ihb335 ,   npc1ihb334/ihb334	whole organism dead, abnormal whole organism decreased length, abnormal whole organism decreased life span, abnormal
	Fig. 3		npc1ihb334/ihb334	cerebellum Purkinje cell decreased amount, abnormal hepatocyte morphology, abnormal hepatocyte vacuolated, abnormal liver cholesterol increased amount, abnormal liver fatty, abnormal
	Fig. 4		npc1ihb335/ihb335 ,   npc1ihb334/ihb334	liver sphingolipid increased amount, abnormal
	Fig. S Movie 1		npc1ihb335/ihb335 ,   npc1ihb334/ihb334	locomotory behavior process quality, abnormal
Tseng et al., 2018	Fig. 2		npc1hg37/hg37	whole organism decreased size, abnormal
	Fig. 3		npc1hg37/hg37	hepatocyte structure, abnormal hindbrain axon structure, abnormal Purkinje cell disorganized, abnormal
	Fig. 4		npc1hg37/hg37	liver npc1 expression absent, abnormal liver cholesterol increased amount, abnormal liver low brightness, abnormal liver opaque, abnormal
	Fig. 5		npc1hg37/hg37	extension cholesterol increased amount, abnormal trunk cholesterol increased amount, abnormal
	Fig. 6		npc1hg37/hg37	yolk syncytial layer cholesterol increased amount, abnormal
	Fig. 7		npc1hg37/hg37	neuromast lysosome increased amount, abnormal
	Fig. 8		npc1hg37/hg37	neuromast cholesterol increased amount, abnormal neuromast lysosome increased amount, abnormal peripheral olfactory organ lysosome increased amount, abnormal
	Fig. S1		npc1y535/y535 ,   npc1hg37/hg37	liver npc1 expression absent, abnormal
	Fig. S2		npc1hg37/hg37	liver low brightness, abnormal liver opaque, abnormal
	text only		npc1hg37/hg37	whole organism decreased life span, abnormal whole organism semi-viable, abnormal whole organism sterile, abnormal
Chu et al., 2015	Fig. 7		WT + MO1-npc1	intracellular cholesterol transport disrupted, abnormal whole organism cholesterol increased amount, abnormal
Louwette et al., 2013	Fig. 4		WT + MO1-npc1	brain morphology, abnormal eye morphology, abnormal head malformed, abnormal programmed cell death increased occurrence, abnormal regulation of cholesterol storage disrupted, abnormal
	Fig. 5		la2Tg + MO1-npc1 ,   sd2Tg + MO1-npc1	blood island thrombocyte absent, abnormal blood island thrombocyte decreased amount, abnormal nucleate erythrocyte decreased amount, abnormal whole organism dead, abnormal
Schwend et al., 2011	Fig. 1		WT + MO1-npc1	cholesterol transport process quality, abnormal trunk sterol spatial pattern, abnormal
	Fig. 3		WT + MO1-npc1	epiboly involved in gastrulation with mouth forming second delayed, abnormal
	Fig. 4		WT + MO1-npc1	epiboly involved in gastrulation with mouth forming second delayed, abnormal
	Fig. 5		WT + MO2-npc1	epiboly involved in gastrulation with mouth forming second delayed, abnormal
	Fig. 6		WT + MO1-npc1	epiboly involved in gastrulation with mouth forming second delayed, abnormal
	Fig. 7		WT + MO1-npc1	actin cytoskeleton organization disrupted, abnormal
	Fig. 8		WT + MO1-npc1	epiboly involved in gastrulation with mouth forming second delayed, abnormal
	Fig. 9		WT + MO1-npc1	cell death increased occurrence, abnormal lateral mesoderm increased width, abnormal notochord increased width, abnormal segmental plate increased width, abnormal whole organism decreased length, abnormal
	text only		WT + MO1-npc1	whole organism viability, abnormal