ZFIN Morpholino: MO2-vegfc

Target Location

Genome Build: GRCz11Chromosome: 1

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-vegfc

No data available

Phenotype

Phenotype resulting from MO2-vegfc

Phenotype	Fish	Figures
cranial blood vessel lacks all parts of type primordial hindbrain channel, abnormal	y1Tg + MO2-vegfc	Fig. 2 from Cohen et al., 2020
lymphangiogenesis disrupted, abnormal	y1Tg + MO2-vegfc	Fig. 2 from Yaniv et al., 2007
posterior cardinal vein vascular sprouts decreased amount, abnormal	y1Tg + MO2-vegfc	Fig. 2 from Cermenati et al., 2013
primordial hindbrain channel angiogenesis decreased process quality, abnormal	y1Tg + MO2-vegfc	Fig. 2 from Cohen et al., 2020
thoracic duct aplastic, abnormal	y1Tg + MO2-vegfc	Fig. 2 from Yaniv et al., 2007

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Phenotype of all Fish created by or utilizing MO2-vegfc

Phenotype	Fish	Conditions	Figures
lymphangiogenesis disrupted, abnormal	WT + MO1-vegfc + MO2-vegfc	standard conditions	Fig. 2 from Hogan et al., 2009
lymphangiogenesis disrupted, abnormal	hu4453Tg + MO1-vegfc + MO2-vegfc	standard conditions	Fig. 2 from Hogan et al., 2009
trunk lymph vasculature aplastic, abnormal	hu4453Tg + MO1-vegfc + MO2-vegfc	standard conditions	Fig. 2 from Hogan et al., 2009
lymphangiogenesis disrupted, abnormal	y1Tg + MO1-vegfc + MO2-vegfc	standard conditions	Fig. 2 from Hogan et al., 2009
lymphangiogenesis disrupted, abnormal	y1Tg + MO2-vegfc	standard conditions	Fig. 2 from Yaniv et al., 2007

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Citations

Include unpublished citations

Moleri, S., Mercurio, S., Pezzotta, A., D'Angelo, D., Brix, A., Plebani, A., Lini, G., Di Fuorti, M., Beltrame, M. (2023) Lymphatic Defects in Zebrafish sox18 Mutants Are Exacerbated by Perturbed VEGFC Signaling, While Masked by Elevated sox7 Expression. Cells. 12(18):
Cohen, B., Tempelhof, H., Raz, T., Oren, R., Nicenboim, J., Bochner, F., Even, R., Jelinski, A., Eilam, R., Ben-Dor, S., Adaddi, Y., Golani, O., Lazar, S., Yaniv, K., Neeman, M. (2020) BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression. Life science alliance. 3(4):
Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., Gibbs-Bar, L., Senderovich, N., Hashimshony, T., Shin, M., Jerafi-Vider, A., Avraham-Davidi, I., Krupalnik, V., Hofi, R., Almog, G., Astin, J.W., Golani, O., Ben-Dor, S., Crosier, P.S., Herzog, W., Lawson, N.D., Hanna, J.H., Yanai, I., Yaniv, K. (2015) Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature. 522(7554):56-61
Cermenati, S., Moleri, S., Neyt, C., Bresciani, E., Carra, S., Grassini, D.R., Omini, A., Goi, M., Cotelli, F., François, M., Hogan, B.M., and Beltrame, M. (2013) Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in Zebrafish. Arterioscler. Thromb. Vasc. Biol.. 33(6):1238-47
Hogan, B.M., Bos, F.L., Bussmann, J., Witte, M., Chi, N.C., Duckers, H.J., and Schulte-Merker, S. (2009) ccbe1 is required for embryonic lymphangiogenesis and venous sprouting. Nature Genetics. 41(4):396-398
Yaniv, K., Isogai, S., Castranova, D., Dye, L., Hitomi, J., and Weinstein, B.M. (2007) Imaging the developing lymphatic system using the zebrafish. Novartis Foundation symposium. 283(1):139-148
Yaniv, K., Isogai, S., Castranova, D., Dye, L., Hitomi, J., and Weinstein, B.M. (2006) Live imaging of lymphatic development in the zebrafish. Nature medicine. 12(6):711-716
Ober, E.A., Olofsson, B., Makinen, T., Jin, S.W., Shoji, W., Koh, G.Y., Alitalo, K., and Stainier, D.Y. (2004) Vegfc is required for vascular development and endoderm morphogenesis in zebrafish. EMBO reports. 5(1):78-84

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