PUBLICATION

ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

Authors
Hogan, B.M., Bos, F.L., Bussmann, J., Witte, M., Chi, N.C., Duckers, H.J., and Schulte-Merker, S.
ID
ZDB-PUB-090319-10
Date
2009
Source
Nature Genetics   41(4): 396-398 (Journal)
Registered Authors
Bos, Frank, Bussmann, Jeroen, Hogan, Ben M., Schulte-Merker, Stefan, Witte, Merlijn
Keywords
none
MeSH Terms
  • Amino Acid Substitution
  • Animals
  • Binding Sites
  • Calcium/metabolism
  • Cell Division
  • Cell Movement
  • Embryo, Nonmammalian/physiology
  • Embryonic Development
  • Epidermal Growth Factor/genetics*
  • Humans
  • Lymphangiogenesis/genetics*
  • Lymphatic Vessels/cytology
  • Lymphatic Vessels/embryology
  • Lymphatic Vessels/physiology*
  • Models, Animal
  • Mutation*
  • Vascular Endothelial Growth Factor C/genetics
  • Zebrafish
PubMed
19287381 Full text @ Nat. Genet.
Abstract
Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes