ZFIN ID: ZDB-GENE-040303-4
Gene Name: vascular endothelial growth factor c
Gene Symbol: vegfc    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Exhibits vascular endothelial growth factor receptor binding activity. Involved in several processes, including motor neuron axon guidance; transmembrane receptor protein tyrosine kinase signaling pathway; and vasculature development. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Is expressed in several structures, including blood vessel; brain; hypochord; nucleate erythrocyte; and trunk. Orthologous to human VEGFC (vascular endothelial growth factor C).
Genome Resources: Alliance (1),  Gene:403049 (1),  Ensembl(GRCz11):ENSDARG00000069640 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu5055 Point Mutation Unknown Missense
hu5142 Point Mutation Unknown Missense ENU
hu6124 Point Mutation Unknown Missense
hu6410 Point Mutation Unknown Unknown
la028142Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • um18 Point Mutation Exon 4 Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-vegfc N/A 20
    MO2-vegfc N/A 6
    MO3-vegfc N/A 2
    MO4-vegfc N/A 5
    MO5-vegfc N/A 1
    DISEASE ASSOCIATED WITH vegfc HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary lymphedema ID Alliance Lymphatic malformation 4 615907
    DISEASE ASSOCIATED WITH vegfc VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sprouting angiogenesis (more)
    Cellular Component membrane (more)
    Molecular Function vascular endothelial growth factor receptor binding (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000072 PDGF/VEGF domain
    Repeat IPR004153 CXCXC repeat
    Conserved_site IPR023581 Platelet-derived growth factor, conserved site
    Homologous_superfamily IPR029034 Cystine-knot cytokine
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA vegfc-201 (1)    Ensembl 1926
    vegfc-202 (1)    Ensembl 525
    ncRNA vegfc-003 (1)    Ensembl 579
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM vegfc
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(4xUAS:vegfc) UAS vegfc Danio rerio 1 4
    Tg(10xUAS:vegfc,cryaa:GFP) cryaaUAS GFPvegfc Danio rerio 1 4
    Tg(hsp70l:vegfc,myl7:EGFP) hsp70lmyl7 EGFPvegfc Danio rerio 1 1
    tg(hsp70l:venus-2a-vegfc,cryaa:venus) cryaahsp70l 2AvegfcVenus Danio rerio 1 1
    Tg(shha:vegfc,mTurquoise) shha mTurquoisevegfc Danio rerio 1 4
    MARKER RELATIONSHIPS
    vegfc Contained in: [BAC] CH73-289G7 (1), DKEY-119H24 (1) (order this)
    vegfc Encodes: [EST] eu252 (1)
    [cDNA] MGC:136707 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205734 (1) 1936 bp
    Genomic GenBank:BX957306 (1) 224487 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q7T3I6 (1) 396 aa
    Sequence Information (all 24)
    ORTHOLOGY for vegfc ( Chr: 1 )
    CITATIONS (119)