Gene
vegfc
- ID
- ZDB-GENE-040303-4
- Name
- vascular endothelial growth factor c
- Symbol
- vegfc Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables vascular endothelial growth factor receptor binding activity. Acts upstream of with a positive effect on lymph vessel development. Acts upstream of or within several processes, including cardiac muscle tissue regeneration; cell surface receptor protein tyrosine kinase signaling pathway; and vasculature development. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in several structures, including cardiovascular system; horizontal myoseptum; hypochord; nervous system; and trunk. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 46 figures from 38 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu252 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 39 figures from 21 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu5055 | Allele with one point mutation | Unknown | Missense | not specified | |
| hu5142 | Allele with one point mutation | Unknown | Missense | ENU | |
| hu6124 | Allele with one point mutation | Unknown | Missense | not specified | |
| hu6410 | Allele with one point mutation | Unknown | Unknown | not specified | |
| la028142Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| um18 | Allele with one point mutation | Exon 4 | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-vegfc | Schiavo et al., 2021 | |
| MO1-vegfc | N/A | (23) |
| MO2-vegfc | N/A | (8) |
| MO3-vegfc | N/A | (3) |
| MO4-vegfc | N/A | (5) |
| MO5-vegfc | N/A | Hoffman et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary lymphedema ID | Alliance | Lymphatic malformation 4 | 615907 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CXCXC repeat | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site | Platelet-derived/Vascular endothelial growth factor |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T3I6 | InterPro | 396 | |||||
| UniProtKB:A0A8M9PHS0 | InterPro | 277 | |||||
| UniProtKB:A0A8M2B6U8 | InterPro | 395 | |||||
| UniProtKB:A0A8M9PC47 | InterPro | 339 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-289G7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-119H24 | ZFIN Curated Data | |
| Encodes | EST | eu252 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:136707 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205734 (1) | 1936 nt | ||
| Genomic | GenBank:BX957306 (2) | 224487 nt | ||
| Polypeptide | UniProtKB:Q7T3I6 (1) | 396 aa |
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Duca, S., Xia, Y., Elmagid, L.A., Bakis, I., Qiu, M., Cao, Y., Guo, Y., Eichenbaum, J.V., McCain, M.L., Kang, J., Harrison, M.R.M., Cao, J. (2024) Differential vegfc expression dictates lymphatic response during zebrafish heart development and regeneration. Development (Cambridge, England). 151(22):
- Veloso, A., Bleuart, A., Conrard, L., Orban, T., Bruyr, J., Cabochette, P., Germano, R.F.V., Schevenels, G., Bernard, A., Zindy, E., Demeyer, S., Vanhollebeke, B., Dequiedt, F., Martin, M. (2024) The cytoskeleton adaptor protein Sorbs1 controls the development of lymphatic and venous vessels in zebrafish. BMC Biology. 22:5151
- Zhou, W., Ghersi, J.J., Ristori, E., Semanchik, N., Prendergast, A., Zhang, R., Carneiro, P., Baldissera, G., Sessa, W.C., Nicoli, S. (2024) Akt is a mediator of artery specification during zebrafish development. Development (Cambridge, England). 151(17):
- Hußmann, M., Schulte, D., Weischer, S., Carlantoni, C., Nakajima, H., Mochizuki, N., Stainier, D.Y.R., Zobel, T., Koch, M., Schulte-Merker, S. (2023) Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner. eLIFE. 12:
- Moleri, S., Mercurio, S., Pezzotta, A., D'Angelo, D., Brix, A., Plebani, A., Lini, G., Di Fuorti, M., Beltrame, M. (2023) Lymphatic Defects in Zebrafish sox18 Mutants Are Exacerbated by Perturbed VEGFC Signaling, While Masked by Elevated sox7 Expression. Cells. 12(18):
- Parab, S., Card, O.A., Chen, Q., America, M., Buck, L.D., Quick, R.E., Horrigan, W.F., Levkowitz, G., Vanhollebeke, B., Matsuoka, R.L. (2023) Local angiogenic interplay of Vegfc/d and Vegfa controls brain region-specific emergence of fenestrated capillaries. eLIFE. 12:
- Arnold, H., Panara, V., Hußmann, M., Filipek-Gorniok, B., Skoczylas, R., Ranefall, P., Gloger, M., Allalou, A., Hogan, B.M., Schulte-Merker, S., Koltowska, K. (2022) mafba and mafbb differentially regulate lymphatic endothelial cell migration in topographically distinct manners. Cell Reports. 39:110982
- El-Sammak, H., Yang, B., Guenther, S., Chen, W., Marín-Juez, R., Stainier, D.Y.R. (2022) A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. Circulation research. 130(7):1014-1029
- Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119e2211690119
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