Gene

vegfc

ID
ZDB-GENE-040303-4
Name
vascular endothelial growth factor c
Symbol
vegfc Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Exhibits vascular endothelial growth factor receptor binding activity. Involved in several processes, including motor neuron axon guidance; transmembrane receptor protein tyrosine kinase signaling pathway; and vasculature development. Predicted to localize to extracellular space. Is expressed in several structures, including blood vessel; brain; hypochord; nucleate erythrocyte; and trunk. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C).
Genome Resources
Note
None
Expression
All Expression Data
35 figures from 28 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
30 figures from 17 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vegfc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary lymphedema ID Alliance Lymphatic malformation 4 615907
Associated With vegfc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023581 Platelet-derived growth factor, conserved site
Domain IPR000072 PDGF/VEGF domain
Homologous_superfamily IPR029034 Cystine-knot cytokine
Repeat IPR004153 CXCXC repeat
Domain Details Per Protein
Protein Length CXCXC repeat Cystine-knot cytokine PDGF/VEGF domain Platelet-derived growth factor, conserved site
UniProtKB:F6P2I4 116
UniProtKB:Q7T3I6 396
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations