ZFIN Morpholino: MO1-vegfaa

Target Location

Genome Build: GRCz11Chromosome: 16

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-vegfaa

No data available

Phenotype

Phenotype resulting from MO1-vegfaa

Phenotype	Fish	Figures
angioblast cell migration delayed, abnormal	WT + MO1-vegfaa	Fig. 8 from Childs et al., 2002
angiogenesis disrupted, abnormal	WT + MO1-vegfaa	Fig. 4 from Jing et al., 2013
angiogenesis process quality, abnormal	s843Tg + MO1-vegfaa	Fig. 2 from Weijts et al., 2012
angiogenic sprout absent, abnormal	WT + MO1-vegfaa	Fig. 8 from Childs et al., 2002
angiogenic sprout physical object quality, abnormal	s843Tg + MO1-vegfaa	Fig. 2 from Weijts et al., 2012

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Phenotype of all Fish created by or utilizing MO1-vegfaa

Phenotype	Fish	Conditions	Figures
angioblast cell migration delayed, abnormal	WT + MO1-vegfaa	standard conditions	Fig. 8 from Childs et al., 2002
blood circulation arrested, abnormal	WT + MO1-vegfaa	standard conditions	Fig. 4 from Rottbauer et al., 2005
angiogenesis disrupted, abnormal	WT + MO1-vegfaa	standard conditions	Fig. 4 from Jing et al., 2013
axial vasculature kdrl expression spatial pattern, abnormal	WT + MO1-vegfaa	standard conditions	Fig. 5 from Pociute et al., 2019
angiogenic sprout absent, abnormal	WT + MO1-vegfaa	standard conditions	Fig. 8 from Childs et al., 2002

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Citations

Include unpublished citations

Dong, X., Jiang, D., Wang, L., Zhao, J., Yu, L., Huang, Y., Wu, X., Zhu, Y., Zhao, Y., Zhao, Q., Zhang, G., Li, X. (2022) VPS28 regulates brain vasculature by controlling neuronal VEGF trafficking through extracellular vesicle secretion. iScience. 25:104042
Metikala, S., Warkala, M., Casie Chetty, S., Chestnut, B., Rufin Florat, D., Plender, E., Nester, O., Koenig, A.L., Astrof, S., Sumanas, S. (2022) Integration of vascular progenitors into functional blood vessels represents a distinct mechanism of vascular growth. Developmental Cell. 57(6):767-782.e6
Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119e2211690119
Tsao, K.C., Lin, Y.C., Chen, Y.T., Lai, S.L., Yang, R.B. (2021) Zebrafish scube1 and scube2 cooperate in promoting Vegfa signaling during embryonic vascularization. Cardiovascular research. 118(4):1074-1087
Wang, Y., Pasparakis, C., Grosell, M. (2021) Role of the cardiovascular system in ammonia excretion in early life stages of zebrafish (Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 321(3):R377-R384
Klems, A., van Rijssel, J., Ramms, A.S., Wild, R., Hammer, J., Merkel, M., Derenbach, L., Préau, L., Hinkel, R., Suarez-Martinez, I., Schulte-Merker, S., Vidal, R., Sauer, S., Kivelä, R., Alitalo, K., Kupatt, C., van Buul, J.D., le Noble, F. (2020) The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models. Nature communications. 11:5319
Hughes, M.C., Zimmer, A.M., Perry, S.F. (2019) The role of internal convection in respiratory gas transfer and aerobic metabolism in larval zebrafish ( Danio rerio). American journal of physiology. Regulatory, integrative and comparative physiology. 316(3):R255-R264
Lai, J.K.H., Gagalova, K.K., Kuenne, C., El-Brolosy, M.A., Stainier, D.Y.R. (2019) Induction of interferon-stimulated genes and cellular stress pathways by morpholinos in zebrafish. Developmental Biology. 454(1):21-28
Pociute, K., Schumacher, J.A., Sumanas, S. (2019) Clec14a genetically interacts with Etv2 and Vegf signaling during vasculogenesis and angiogenesis in zebrafish. BMC Developmental Biology. 19:6
Toselli, C.M., Wilkinson, B.M., Paterson, J., Kieffer, T.J. (2019) Vegfa/vegfr2 signaling is necessary for zebrafish islet vessel development, but is dispensable for beta-cell and alpha-cell formation. Scientific Reports. 9:3594

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