ZFIN ID: ZDB-GENE-990415-273
Gene Name: vascular endothelial growth factor Aa
Gene Symbol: vegfaa    Nomenclature History

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Previous Names: vegf-a (1), vegf (1), vegfa (1), etID309976.16 (1), wu:fj82c06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Exhibits growth factor activity. Involved in several processes, including animal organ development; circulatory system development; and regulation of vasculature development. Predicted to localize to extracellular space. Used to study proteinuria. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hypertension (multiple); reproductive organ cancer (multiple); and retinal disease (multiple). Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; podocyte; and trunk. Orthologous to human VEGFA (vascular endothelial growth factor A).
Genome Resources: Alliance (1),  Gene:30682 (1),  Ensembl(GRCz11):ENSDARG00000103542 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns1 Small Deletion Unknown Frameshift, Premature Stop TALEN
bns242 Small Deletion Promoter Unknown CRISPR
bns301 Small Deletion Exon 1 Unknown CRISPR
zf1090 Small Deletion Unknown Unknown TALEN
zf1091 Small Deletion Unknown Unknown TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-vegfaa 1
CRISPR2-vegfaa 1
CRISPR3-vegfaa 1
MO1-vegfaa N/A 44
MO2-vegfaa N/A 9
MO3-vegfaa N/A 9
MO4-vegfaa N/A 2
MO5-vegfaa N/A 1
MO6-vegfaa N/A 1
MO7-vegfaa N/A 1
MO8-vegfaa N/A 1
MO9-vegfaa N/A 1
MO10-vegfaa N/A 2
TALEN1-vegfaa 2
TALEN2-vegfaa 1
PHENOTYPE
Data: 44 figures from 24 publications
Observed in:
DISEASE ASSOCIATED WITH vegfaa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Microvascular complications of diabetes 1} 603933
DISEASE ASSOCIATED WITH vegfaa VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
proteinuria WT + MO10-vegfaa standard conditions Müller-Deile et al., 2017
GENE ONTOLOGY
Ontology GO Term
Biological Process activation of phospholipase C activity (more)
Cellular Component extracellular region (more)
Molecular Function protein binding (more)
GO Terms (all 47)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA vegfaa-201 (1)    Ensembl 2658
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-vegfaa polyclonal IgG Goat WB R&D Systems
2
CONSTRUCTS WITH SEQUENCES FROM vegfaa
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(actb2:LOXP-TagBFP-LOXP-vegfaa) actb2 LOXPTagBFPvegfaa Danio rerio 1 1
Tg(hsp70l:dnvegfaa) hsp70l vegfaa Danio rerio 1 3
tg(hsp70l:loxp-stop-loxp-tomato-dnvegfaa,cryaa:cerulean) cryaahsp70l CeruleanLOXPTomatovegfaa Danio rerio 1 1
Tg(hsp70l:vegfaa) hsp70l vegfaa Danio rerio 1 3
Tg(hsp70l:vegfaa,cryaa:Cerulean) cryaahsp70l Ceruleanvegfaa Danio rerio 1 1
Tg(hsp70l:vegfaa,myl7:EGFP) hsp70lmyl7 EGFPvegfaa Danio rerio 1 5
Tg(hsp70l:vegfaa-2A-mCherry) hsp70l 2AmCherryvegfaa Danio rerio 1 2
tg(ins:loxp-gfp-loxp-ma-tomato-2a-dnvegfaa) ins 2AGFPLOXPMATomatovegfaa Danio rerio 1 1
tg(ins:ma-tomato-2a-dnvegfaa) ins 2AMATomatovegfaa Danio rerio 0 1
tg(ins:tagrfpt-2a-dnvegfaa) ins 2ATagRFPTvegfaa Danio rerio 1 1
TgBAC(vegfaa:EGFP) vegfaa EGFP Danio rerio 1 5
MARKER RELATIONSHIPS
vegfaa Contained in: [BAC] CH211-169N14
vegfaa Encodes: [EST] fj82c06
[cDNA] MGC:193838 (1), MGC:193849 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131408 (1) 567 nt
Genomic GenBank:BX470147 (1) 151584 nt
Select Tool
Polypeptide UniProtKB:O73682 (1) 188 aa
Sequence Information (all 28)
ORTHOLOGY for vegfaa ( Chr: 16 )
CITATIONS (290)