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Tarbashevich et al., 2026 - Cell-autonomous control coupled with tissue context regulates the cessation of migration at the site of organ development

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Fig. 3.

Cellular events during motility loss. (A) PGCs at gonad region and ectopic positions were examined for blebbing activity and polarity. Localization of Lifeact and Ezrin in ectopic and gonadal PGCs. Scale bars: 5 µm. (B,D) Blebbing frequency in ectopic PGCs (B) and in PGCs at the gonad (D). Ectopic PGCs: 9 (24-26 hpf), 11 (34-36 hpf); gonadal PGCs: 10 (24-26 hpf), 10 (34-36 hpf). (C,E) Quantification of the PGC polarity based on the cell front/back ratio for the Lifeact fluorescence. Ectopic PGCs: 38 (24-26 hpf), 37 (34-36 hpf); gonadal PGCs: 35 (24-26 hpf), 43 (34-36 hpf). For B-E, Mann–Whitney test. Data are median±error bars (IQR). (F) Embryos at 15-35 hpf were used for FACS of PGCs (magenta) and sequencing. (G-I) Normalized levels of mRNAs important for PGC development (G), contractility (H) and adhesion/differentiation (I).

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