ZFIN ID: ZDB-GENE-011221-1
Gene Name: nanos homolog 3
Gene Symbol: nanos3    Nomenclature History

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Previous Names: nanos1 (1), nanos (1), nos1 (1), cb725 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have RNA binding activity and zinc ion binding activity. Involved in female germ-line stem cell population maintenance and oocyte growth. Localizes to the P granule. Is expressed in blastodisc; germ line cell; reproductive system; and unfertilized egg. Orthologous to several human genes including NANOS3 (nanos C2HC-type zinc finger 3).
Genome Resources: Alliance (1),  Gene:140631 (1),  Ensembl(GRCz11):ENSDARG00000068255 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh49 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-nanos3 N/A 1
DISEASE ASSOCIATED WITH nanos3 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH nanos3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process female gamete generation (more)
Cellular Component cytoplasm (more)
Molecular Function metal ion binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR008705 Nanos/Xcat2
Domain IPR024161 Zinc finger, nanos-type
Homologous_superfamily IPR038129 Nanos domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nanos3-201 (1)    Ensembl 1127
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
AB1-nanos3 polyclonal Mouse IHC 1
CONSTRUCTS WITH SEQUENCES FROM nanos3
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(hsp70l:cxcl12a-UTR-nanos3,EGFP-UTR-nanos3) hsp70l cxcl12aEGFPnanos3 Danio rerio 1 2
Tg(kop:Cre-UTR-nanos3,CMV:EGFP) kop CreEGFPnanos3 Danio rerio 1 4
Tg(kop:DsRed-UTR-nanos3) kop DsRednanos3 Danio rerio 1 3
Tg(kop:DsRedx-UTR-nanos3) kop DsRedxnanos3 Danio rerio 1 3
Tg(kop:EGFP-actb2-UTR-nanos3) kop actb2EGFPnanos3 Danio rerio 1 2
Tg(kop:EGFP-FTASE-UTR-nanos3) kop EGFPFTASEnanos3 Danio rerio 1 24
Tg(kop:EGFP-LIFEACT-UTR-nanos3) kop EGFPLIFEACTnanos3UTR Danio rerio 1 7
Tg(kop:EGFP-nanos3,cryaa:DsRed) cryaakop DsRedEGFPnanos3 Danio rerio 1 2
Tg(kop:gra-DsRedx-UTR-nanos3) kop DsRedxgrananos3 Danio rerio 1 6
Tg(kop:KALTA4-UTR-nanos3,CMV:EGFP) kop EGFPKALTA4nanos3 Danio rerio 1 4
Tg(kop:KALTA4-UTR-nanos3,CMV:EGFPdel-SV40) CMVkop EGFPKALTA4nanos3UTR Danio rerio 1 1
Tg(kop:KALTA4-UTRnanos3,CMV:EGFPins-SV40) CMVkop EGFPinsKALTA4nanos3UTR Danio rerio 1 1
Tg(kop:LOXP-SV40-LOXP-bbc3-UTR-nanos3,CMV:EGFP) CMVkop bbc3EGFPnanos3 Danio rerio 1 2
Tg(kop:LOXP-SV40-LOXP-mRFP-UTR-nanos3,CMV:EGFP) kop EGFPmRFPnanos3 Danio rerio 1 3
Tg(kop:mCherry-FTASE-UTR-nanos3) kop FTASEmCherrynanos3UTR Danio rerio 1 6
Tg(kop:mCherryF-nanos3-UTR,cmlc1:EGFP) cmlc1kop EGFPmCherrynanos3UTR Danio rerio 1 1
Tg(kop:rac1a_G12V-UTR-nanos3,CMV:EGFP) CMVkop EGFPnanos3rac1a Danio rerio 1 2
tg(nanos3:ntr-mcherry-utr-nanos3) nanos3 mCherrynanos3NTRUTR Danio rerio 1 1
Tg(piwil1:EGFP-UTRnanos3) piwil1 EGFPnanos3UTR Danio rerio 1 3
Tg(UAS:bbc3-UTR-nanos3,CMV:EGFP) CMVUAS bbc3EGFPnanos3 Danio rerio 1 3
Tg(UAS:bmf1-UTR-nanos3,CMV:EGFP) CMVUAS bmf1EGFPnanos3UTR Danio rerio 1 3
Tg(UAS:bmp2b-UTRnanos3) UAS bmp2bnanos3UTR Danio rerio 1 1
Tg(UAS:buc-UTRnanos3) UAS bucnanos3UTR Danio rerio 1 2
Tg(UAS:casp3a-UTR-nanos3,CMV:EGFP) CMVUAS casp3aEGFPnanos3UTR Danio rerio 1 3
Tg(UAS:d2EGFP-UTRnanos3) UAS d2EGFPnanos3UTR Danio rerio 1 1
Tg(UAS:dkk1b-UTRnanos3) UAS dkk1bnanos3UTR Danio rerio 1 1
Tg(UAS:dnbmpr1aa-UTRnanos3) UAS bmpr1aananos3UTR Danio rerio 1 1
Tg(UAS:dnghra-UTRnanos3) UAS ghrananos3UTR Danio rerio 1 1
Tg(UAS:fgf8a-UTRnanos3) UAS fgf8ananos3UTR Danio rerio 1 1
Tg(UAS:lft1-UTRnanos3) UAS lft1nanos3UTR Danio rerio 1 1
Tg(UAS:mRFP-UTR-nanos3,CMV:EGFP) CMVUAS EGFPmRFPnanos3 Danio rerio 1 3
Tg(UAS:mRFP-UTRnanos3) UAS mRFPnanos3UTR Danio rerio 1 1
Tg(UAS:ndr1-UTRnanos3) UAS nanos3ndr1UTR Danio rerio 1 1
Tg(UAS:rac1a_G12V-UTR-nanos3,CMV:EGFP) CMVUAS EGFPnanos3rac1aUTR Danio rerio 2 3
Tg(UAS:spry2-UTRnanos3) UAS nanos3spry2UTR Danio rerio 1 1
Tg(UAS:Spy.Cas9-UTRnanos3) UAS nanos3UTR Danio rerio 1 1
Tg(UAS:Ssc.caGhr-UTRnanos3) UAS nanos3UTR Danio rerioSus scrofa 1 1
Tg(UAS:wnt8a-UTRnanos3) UAS nanos3UTRwnt8a Danio rerio 1 1
Tg1(kop:EGFP-UTR-nanos3) kop EGFPnanos3 Danio rerio 1 4
MARKER RELATIONSHIPS
nanos3 Contained in: [BAC] CH211-286B5 (1)
nanos3 Encodes: [EST] cb725 (1) (order this)
[cDNA] MGC:114022 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131878 (1) 1141 bp
Genomic GenBank:BX284640 (1) 158537 bp
Select Tool
Polypeptide UniProtKB:Q4QRE8 (1) 159 aa
Sequence Clusters UniGene:83493 (1)
Sequence Information (all 14)
ORTHOLOGY for nanos3 ( Chr: 1 )
CITATIONS (133)