Gene
dnd1
- ID
- ZDB-GENE-030828-4
- Name
- DND microRNA-mediated repression inhibitor 1
- Symbol
- dnd1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Enables mRNA 3'-UTR binding activity. Acts upstream of or within several processes, including germ cell migration; heart contraction; and mRNA stabilization. Located in P granule and germ cell nucleus. Is expressed in blastodisc; brain; heart; reproductive system; and unfertilized egg. Orthologous to human DND1 (DND microRNA-mediated repression inhibitor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 21 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb736 (22 images)
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 10 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dnd1 | Chu et al., 2023 | |
| CRISPR2-dnd1 | Zebrafish Nomenclature Committee | |
| MO1-dnd1 | N/A | (47) |
| MO2-dnd1 | N/A | Gross-Thebing et al., 2017 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | DND1, double-stranded RNA binding domain | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|
|
UniProtKB:B2GPX0
|
411 | ||||
|
UniProtKB:Q7T1H5
|
411 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(5xUAS:dnd1,CMV:RFP) |
|
| 1 | (3) | |
| Tg(-8.3dnd1:NPT-UTRdnd1) |
|
| 1 | Wong et al., 2013 | |
| Tg(-8.15dnd1:NPT-UTRdnd1) |
|
| 1 | Wong et al., 2013 | |
| Tg(dnd1:NTR-EGFP) |
|
| 1 | Dai et al., 2015 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-235C4 | ZFIN Curated Data | |
| Contains | STS | chunp30290 | ||
| Encodes | EST | cb736 | Thisse et al., 2001 | |
| Encodes | EST | fi22d10 | ||
| Encodes | cDNA | MGC:111864 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191688 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212795 (1) | 1765 nt | ||
| Genomic | GenBank:BX890575 (2) | 204730 nt | ||
| Polypeptide | UniProtKB:B2GPX0 (1) | 411 aa |
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Chu, W.K., Huang, S.C., Chang, C.F., Wu, J.L., Gong, H.Y. (2023) Infertility control of transgenic fluorescent zebrafish with targeted mutagenesis of the dnd1 gene by CRISPR/Cas9 genome editing. Frontiers in genetics. 14:10292001029200
- Li, W., Liu, W., Mo, C., Yi, M., Gui, J. (2023) Two Novel lncRNAs Regulate Primordial Germ Cell Development in Zebrafish. Cells. 12(4):
- Wang, X., Zhu, J., Wang, H., Deng, W., Jiao, S., Wang, Y., He, M., Zhang, F., Liu, T., Hao, Y., Ye, D., Sun, Y. (2023) Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors. Nature communications. 14:79187918
- Westerich, K.J., Reinecke, S., Emich, J., Wyrwoll, M.J., Stallmeyer, B., Meyer, M., Oud, M.S., Fietz, D., Pilatz, A., Kliesch, S., Reichman-Fried, M., Tarbashevich, K., Limon, T., Stehling, M., Friedrich, C., Tüttelmann, F., Raz, E. (2023) Linking human Dead end 1 (DND1) variants to male infertility employing zebrafish embryos. Human reproduction (Oxford, England). 38(4):655-670
- Sun, X., Tao, B., Wang, Y., Hu, W., Sun, Y. (2022) Isolation and Characterization of Germline Stem Cells in Protogynous Hermaphroditic Monopterus albus. International Journal of Molecular Sciences. 23(11)
- Tao, B., Hu, H., Chen, J., Chen, L., Luo, D., Sun, Y., Ge, F., Zhu, Z., Trudeau, V.L., Hu, W. (2022) Sinhcaf-dependent histone deacetylation is essential for primordial germ cell specification. EMBO reports. 23(6):e54387
- Zhai, G., Shu, T., Yu, G., Tang, H., Shi, C., Jia, J., Lou, Q., Dai, X., Jin, X., He, J., Xiao, W., Liu, X., Yin, Z. (2022) Augmentation of progestin signaling rescues testis organization and spermatogenesis in zebrafish with the depletion of androgen signaling. eLIFE. 11:
- Zhang, R., Tu, Y.X., Ye, D., Gu, Z., Chen, Z.X., Sun, Y. (2022) A Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 9(36):e2203631
- Dai, X., Cheng, X., Huang, J., Gao, Y., Wang, D., Feng, Z., Zhai, G., Lou, Q., He, J., Wang, Z., Yin, Z. (2021) Rbm46, a novel germ cell specific factor, modulates meiotic progression and spermatogenesis. Biology of reproduction. 104(5):1139-1153
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