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Chen et al., 2025 - Ddx3xa mutations drive cardiac defects in a zebrafish model via dysregulation of wnt/β-catenin signaling

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FIGURE 7

Validation and pathway analysis of cardiac development genes in ddx3xa^−/− zebrafish. (A) qRT-PCR validation of genes related to cardiac contraction, vascular smooth muscle contraction, calcium signaling, and actin cytoskeleton regulation in ddx3xa^−/− mutants versus wild-type (WT) at 72 hpf (n = 3; *P < 0.05, **P < 0.01, ***P < 0.001). (B) Pathway-gene interaction network for enriched cardiac development pathways generated using Cytoscape. (C) Heatmap of RNA-Seq expression profiles for enriched genes across key cardiac development pathways.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Mol Biosci