Gene

ntrk1

ID
ZDB-GENE-980526-118
Name
neurotrophic tyrosine kinase, receptor, type 1
Symbol
ntrk1 Nomenclature History
Previous Names
  • trk
  • trkA (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Involved in defense response to bacterium; inflammatory response to wounding; and neutrophil mediated immunity. Predicted to localize to axon; integral component of plasma membrane; and receptor complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
16 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ntrk1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary sensory neuropathy type 4 Alliance Insensitivity to pain, congenital, with anhidrosis 256800
Associated With ntrk1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003599 Immunoglobulin domain subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR031635 Growth factor receptor NTRK, leucine rich repeat C-terminal
Domain IPR040665 Tyrosine kinase receptor A, transmembrane domain
Family IPR020461 High affinity nerve growth factor receptor NTRK1
Family IPR020777 Growth factor receptor NTRK
Family IPR050122 Receptor Tyrosine Kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Repeat IPR001611 Leucine-rich repeat
Domain Details Per Protein
Protein Length Growth factor receptor NTRK Growth factor receptor NTRK, leucine rich repeat C-terminal High affinity nerve growth factor receptor NTRK1 Immunoglobulin domain subtype Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Leucine-rich repeat Leucine-rich repeat domain superfamily Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Receptor Tyrosine Kinase Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine kinase receptor A, transmembrane domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class II, conserved site
UniProtKB:F6P1M3 797
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA ntrk1-201 (1) Ensembl 3114 nt
mRNA ntrk1-202 (1) Havana 2663 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations