Gene

cxcl12b

ID
ZDB-GENE-030721-1
Name
chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)
Symbol
cxcl12b Nomenclature History
Previous Names
  • SDF-1b (2)
  • SDF1b (1)
  • zgc:136720
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Enables chemoattractant activity. Involved in axon guidance and positive regulation of cell migration. Acts upstream of or within with a positive effect on Kupffer's vesicle development. Acts upstream of or within several processes, including blood vessel morphogenesis; induction of positive chemotaxis; and nervous system development. Predicted to be located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; endoderm; head; and mesoderm. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
44 figures from 26 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cxcl12b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{AIDS, resistance to} 609423
Associated With cxcl12b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001811 Chemokine interleukin-8-like domain
Domain IPR033899 CXC Chemokine domain
Family IPR039813 Stromal cell-derived factor 1
Homologous_superfamily IPR036048 Chemokine interleukin-8-like superfamily
Domain Details Per Protein
Protein Length Chemokine interleukin-8-like domain Chemokine interleukin-8-like superfamily CXC Chemokine domain Stromal cell-derived factor 1
UniProtKB:Q6V9B5 97
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations