Gene
ptger1b
- ID
- ZDB-GENE-100922-278
- Name
- prostaglandin E receptor 1b (subtype EP1)
- Symbol
- ptger1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables prostaglandin E receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; inflammatory response; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Orthologous to human PTGER1 (prostaglandin E receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Prostanoid receptor | Thromboxane receptor |
|---|---|---|---|---|---|---|
| UniProtKB:D0EXE2 | InterPro | 390 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptger1b-201
(1)
|
Ensembl | 1,358 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-61N16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001166333 (1) | 1358 nt | ||
| Genomic | GenBank:AL935209 (1) | 162012 nt | ||
| Polypeptide | UniProtKB:D0EXE2 (1) | 390 aa |
- Cacialli, P., Mailhe, M.P., Wagner, I., Merkler, D., Golub, R., Bertrand, J.Y. (2022) Synergistic prostaglandin E synthesis by myeloid and endothelial cells promotes fetal hematopoietic stem cell expansion in vertebrates. The EMBO journal. 41(19):e108536
- Baker, S.J.C., Van Der Kraak, G. (2019) Investigating the role of prostaglandin receptor isoform EP4b in zebrafish ovulation. General and comparative endocrinology. 283:113228
- Tang, H., Liu, Y., Li, J., Yin, Y., Li, G., Chen, Y., Li, S., Zhang, Y., Lin, H., Liu, X., Cheng, C.H. (2016) Gene knockout of nuclear progesterone receptor provides insights into the regulation of ovulation by LH signaling in zebrafish. Scientific Reports. 6:28545
- Iwasaki, R., Tsuge, K., Morimoto, K., Inazumi, T., Kawahara, O., Kawahara, A., Tsuchiya, S., and Sugimoto, Y. (2013) Molecular and pharmacological characterization of zebrafish 'contractile' and 'inhibitory' prostanoid receptors. Biochemical and Biophysical Research Communications. 438(2):353-8
- Kwok, A.H., Wang, Y., and Leung, F.C. (2012) Molecular characterization of prostaglandin F receptor (FP) and E receptor subtype 1 (EP(1)) in zebrafish. General and comparative endocrinology. 178(2):216-226
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