ZFIN ID: ZDB-GENE-990415-45
Gene Name: phospholipase A2, group IVAa (cytosolic, calcium-dependent)
Gene Symbol: pla2g4aa    Nomenclature History

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Previous Names: cpla2, pla2g4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits phospholipase activity. Involved in inflammatory response to wounding; ovarian follicle development; and regulation of G1/S transition of mitotic cell cycle. Predicted to localize to several cellular components, including the Golgi apparatus; cytosol; and endoplasmic reticulum. Is expressed in brain; otic vesicle; and ovary. Orthologous to human PLA2G4A (phospholipase A2 group IVA).
Genome Resources: Alliance (1),  Gene:30554 (1),  Ensembl(GRCz11):ENSDARG00000024546 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023497Tg Transgenic Insertion Unknown Unknown DNA
sa7312 Point Mutation Unknown Premature Stop ENU
sa39810 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pla2g4aa N/A 2
    MO2-pla2g4aa N/A 2
    MO3-pla2g4aa N/A 1
    MO4-pla2g4aa N/A 1
    PHENOTYPE
    Data: Fig. 4 from Naini et al., 2016
    Observed in:
    DISEASE ASSOCIATED WITH pla2g4aa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Gastrointestinal ulceration, recurrent, with dysfunctional platelets 618372
    DISEASE ASSOCIATED WITH pla2g4aa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of G1/S transition of mitotic cell cycle (more)
    Cellular Component cytoplasm (more)
    Molecular Function phospholipase activity (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000008 C2 domain
    Domain IPR002642 Lysophospholipase, catalytic domain
    Domain IPR041847 Cytosolic phospholipase A2, C2 domain
    Homologous_superfamily IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
    Homologous_superfamily IPR035892 C2 domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pla2g4aa-201 (1)    Ensembl 2591
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pla2g4aa
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:pla2g4aa-mKate2) hsp70l mKate2pla2g4aa Danio rerio 1 2
    MARKER RELATIONSHIPS
    pla2g4aa Contained in: [BAC] CH73-86N6 (1), CH73-147D18 (1), CH73-156H13 (1)
    pla2g4aa Encodes: [cDNA] MGC:193527 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131295 (1) 2592 nt
    Genomic GenBank:CU570979 (1) 105710 nt
    Select Tool
    Polypeptide UniProtKB:B3DFL0 (1) 741 aa
    Sequence Information (all 15)
    ORTHOLOGY for pla2g4aa ( Chr: 2 )
    CITATIONS (48)