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Jiang et al., 2024 - A Mechanistic Study of the Osteogenic Effect of Arecoline in an Osteoporosis Model: Inhibition of Iron Overload-Induced Osteogenesis by Promoting Heme Oxygenase-1 Expression

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Figure 4

RNA-seq identified that ferroptosis may be involved in anti-osteoporosis effect of ACL under FAC exposure. (A) KEGG pathway enrichment analysis of all differentially expressed genes (DEGs) between ACL and ACL + FAC groups. (B) KEGG pathway enrichment analysis of down-regulated genes in ACL + FAC treated zebrafish larvae compared to ACL treated larvae. (C) Heatmap of 11 ferroptosis-related genes identified from DEGs. FAC represents the group treated with FAC alone, while ACL represents the group treated with both FAC and ACL. Each row represents one gene, and each column represents one sample. Red represents genes with high expression, blue represents genes with low expression. Darker colors indicate more significant differences. (D) Verification of mRNA expression level of ferroptosis-related genes in 5 dpf zebrafish larvae treated with 200 µg/mL FAC with or without 0.5 mg/L ACL. (E) Quantitative analysis of mRNA expression levels of three apoptosis genes, P53, casp3a and casp9. * means p < 0.05 between two indicated groups (n = 6). Data are displayed as mean ± SD.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Antioxidants (Basel)