Gene

casp9

ID
ZDB-GENE-030825-5
Name
caspase 9, apoptosis-related cysteine peptidase
Symbol
casp9 Nomenclature History
Previous Names
  • im:7136887
  • zgc:101776
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have cysteine-type endopeptidase activity involved in apoptotic signaling pathway and cysteine-type endopeptidase activity involved in execution phase of apoptosis. Involved in several processes, including positive regulation of apoptotic process; regulation of collateral sprouting in absence of injury; and renal filtration. Predicted to localize to cytoplasm. Is expressed in gut; muscle cell; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With casp9 Human Ortholog
No data available
Associated With casp9 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016129 Peptidase family C14A, His active site
Active_site IPR033139 Peptidase family C14A, cysteine active site
Domain IPR001309 Peptidase C14, p20 domain
Domain IPR001315 CARD domain
Domain IPR002138 Peptidase C14, caspase non-catalytic subunit p10
Domain IPR015917 Peptidase C14A, caspase catalytic domain
Domain IPR042147 CASP9, CARD domain
Family IPR002398 Peptidase C14 family
Family IPR033171 Caspase-9
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR029030 Caspase-like domain superfamily
Domain Details Per Protein
Protein Length CARD domain CASP9, CARD domain Caspase-9 Caspase-like domain superfamily Death-like domain superfamily Peptidase C14A, caspase catalytic domain Peptidase C14, caspase non-catalytic subunit p10 Peptidase C14 family Peptidase C14, p20 domain Peptidase family C14A, cysteine active site Peptidase family C14A, His active site
UniProtKB:A0A2U9DQQ3 436
UniProtKB:Q5U3Q7 436
UniProtKB:F1QSB1 436
UniProtKB:Q4V923 436
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations