ZFIN Image: Wang et al., 2013, Fig. 6

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Figure Caption

Fig. 6 Cardiac valve genes were abnormally expressed in the AVC of sco^te382 mutant hearts. (A-R) Wild-type (A-C,G-I, M-N,Q) and sco^te382 (D-F,J–L,O-P,R) embryos were analyzed by in situ hybridization with cardiac valve markers notch1b (A-F), bmp4 (G–L), dll4 (M-P) and spp1 (Q–R) at 48hpf (A,D,G,J), 60hpf (B,E,H,K,M,O), and 72hpf (C,F,I,L,N,P–R). Note that endocardial notch1b and dll4 were ectopically expressed in the ventricle of sco^te382 mutants but myocardial bmp4 was not affected in sco^te382 mutants from 48 to 72hpf. spp1, an endocardial–mesenchymal transition marker gene, was not expressed in the AVC of sco^te382 mutants (red arrowhead in R). The atrium and ventricle are demarcated with red arrowheads. Black arrowheads (Q,R) point to the outflow tract. a, atrium; v, ventricle; wt, wild type. Dotted lines outline the heart.

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Acknowledgments

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