Gene

cyp2r1

ID

ZDB-GENE-110114-1

Name

cytochrome P450, family 2, subfamily R, polypeptide 1

Symbol

cyp2r1 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within cellular response to vitamin D; hematopoietic stem cell proliferation; and vitamin D3 metabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver; muscle; ovary; and visceral fat. Used to study vitamin D-dependent rickets type 1B. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and vitamin D-dependent rickets type 1B. Orthologous to human CYP2R1 (cytochrome P450 family 2 subfamily R member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyp2r1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
vitamin D-dependent rickets type 1B	Alliance	Rickets due to defect in vitamin D 25-hydroxylation deficiency	600081

Associated With cyp2r1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
vitamin D-dependent rickets type 1B	cyp2r1^zf734/zf734	standard conditions	Cortes et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

No data available

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cyp2r1-201 (1) Ensembl	Ensembl	2,317 nt	Select Tool ZFIN BLAST
mRNA	cyp2r1-202 (1) Ensembl	Ensembl	886 nt	Select Tool ZFIN BLAST
mRNA	cyp2r1-203 (1) Ensembl	Ensembl	813 nt	Select Tool ZFIN BLAST
ncRNA	cyp2r1-003 (1) Ensembl	Ensembl	314 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations