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ZIRC
ZFIN ID: ZDB-GENE-050302-113
Gene Name: neuregulin 1
Gene Symbol: nrg1    Nomenclature History

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Previous Name: wu:fm70e01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have signaling receptor binding activity. Involved in several processes, including fin regeneration; nervous system development; and ventricular trabecula myocardium morphogenesis. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; dementia; middle cerebral artery infarction; myocardial infarction; and psychotic disorder (multiple). Is expressed in gut; heart; nervous system; and somite. Orthologous to human NRG1 (neuregulin 1).
Genome Resources: Alliance (1),  Gene:796461 (1),  Ensembl(GRCz11):ENSDARG00000104314 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns101 Small Deletion Exon 2 Frameshift, Premature Stop TALEN
hg114 Small Deletion Unknown Unknown CRISPR
la017618Tg Transgenic Insertion Unknown Unknown DNA
la027207Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • nc26 Small Deletion Exon 6 Frameshift, Premature Stop CRISPR
    nc27 Small Deletion Exon 6 Frameshift, Premature Stop CRISPR
    nc28 Indel Exon 3 Frameshift, Premature Stop CRISPR
    nc29 Indel Exon 3 Frameshift, Premature Stop CRISPR
    sa45389 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • z26 Point Mutation Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nrg1 1
    CRISPR2-nrg1 1
    MO1-nrg1 N/A 4
    MO2-nrg1 N/A 2
    MO3-nrg1 N/A 1
    MO4-nrg1 N/A 1
    MO5-nrg1 N/A 1
    MO6-nrg1 N/A 1
    MO7-nrg1 N/A 1
    MO8-nrg1 N/A 1
    TALEN1-nrg1 1
    DISEASE ASSOCIATED WITH nrg1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    schizophrenia 6 Alliance {?Schizophrenia, susceptibility to} 603013
    DISEASE ASSOCIATED WITH nrg1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neural crest cell migration (more)
    Cellular Component integral component of membrane (more)
    Molecular Function signaling receptor binding (more)
    GO Terms (all 18)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nrg1-202 (1)    Ensembl 2193
    nrg1-204 (1)    Ensembl 2991
    nrg1-205 (1)    Ensembl 2645
    ncRNA nrg1-002 (1) 511
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab3-nrg1 Rabbit 1
    Ab2-nrg1 Rabbit 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nrg1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(5xUAS:mCherry-nrg1-EGFP) UAS EGFPmCherrynrg1 Danio rerio 1 1
    Tg(actb2:LOXP-TagBFP-STOP-LOXP-nrg1) actb2 LOXPnrg1TagBFP Danio rerio 1 5
    Tg(lepb:nrg1,eef1a1l1:NLS-mCherry) eef1a1l1lepb mCherryNLSnrg1 Danio rerio 1 1
    Tg(LLE-lepb:nrg1,eef1a1l1:NLS-mCherry) eef1a1l1lepbLLE mCherryNLSnrg1 Danio rerio 1 1
    MARKER RELATIONSHIPS
    nrg1 Contained in: [BAC] CH73-386K7 (1) (order this), DKEY-237I12 (1) (order this), DKEYP-45E9 (1), DKEYP-73E12 (1)
    nrg1 Encodes: [EST] fm70e01
    [cDNA] MGC:195082 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001044911 (1) 2653 bp
    Genomic GenBank:BX537303 (1) 204522 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IBM0 (1) 730 aa
    Sequence Clusters UniGene:133124 (1)
    Sequence Information (all 66)
    ORTHOLOGY for nrg1 ( Chr: 10 )
    CITATIONS (56)