Gene
rp2
- ID
- ZDB-GENE-040426-2795
- Name
- RP2 activator of ARL3 GTPase
- Symbol
- rp2 Nomenclature History
- Previous Names
-
- nme10 (1)
- wu:fj10e02
- wu:fm72d05
- zgc:55632
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity. Acts upstream of or within several processes, including heart looping; photoreceptor cell maintenance; and photoreceptor cell outer segment organization. Predicted to be located in cell projection and plasma membrane. Predicted to be active in cilium and periciliary membrane compartment. Is expressed in several structures, including fertilized egg; liver and biliary system; pleuroperitoneal region; sensory system; and trunk. Used to study retinitis pigmentosa 2. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 2. Orthologous to human RP2 (RP2 activator of ARL3 GTPase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55632 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| retinitis pigmentosa 2 | Alliance | Retinitis pigmentosa 2 | 312600 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| retinitis pigmentosa 2 | rp2hzu2/hzu2 | standard conditions | Liu et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006599 | CARP motif |
| Domain | IPR012945 | Tubulin binding cofactor C-like domain |
| Domain | IPR017901 | C-CAP/cofactor C-like domain |
| Family | IPR039093 | Protein XRP2 |
| Homologous_superfamily | IPR016098 | Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal |
| Homologous_superfamily | IPR036223 | Adenylate cyclase-associated CAP, C-terminal superfamily |
| Homologous_superfamily | IPR036850 | Nucleoside diphosphate kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Adenylate cyclase-associated CAP, C-terminal superfamily | CARP motif | C-CAP/cofactor C-like domain | Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal | Nucleoside diphosphate kinase-like domain superfamily | Protein XRP2 | Tubulin binding cofactor C-like domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QC45
|
376 |
Interactions and Pathways
No data available
Plasmids