Gene

ptk2aa

ID
ZDB-GENE-031114-5
Name
protein tyrosine kinase 2aa
Symbol
ptk2aa Nomenclature History
Previous Names
  • ptk2.2
  • fak1b (1)
  • fakb (1)
  • si:ch1073-355e8.1
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation and signal complex assembly. Predicted to localize to several cellular components, including cytoskeleton; focal adhesion; and integral component of membrane. Is expressed in head; midbrain; midbrain hindbrain boundary; and paraxial mesoderm. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptk2aa Human Ortholog
No data available
Associated With ptk2aa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000299 FERM domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR005189 Focal adhesion kinase, targeting (FAT) domain
Domain IPR019748 FERM central domain
Domain IPR019749 Band 4.1 domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR041390 Focal adhesion kinase, N-terminal
Domain IPR041784 FAK1/PYK2, FERM domain C-lobe
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR014352 FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR035963 FERM superfamily, second domain
Homologous_superfamily IPR036137 Focal adhesion kinase, targeting (FAT) domain superfamily
Domain Details Per Protein
Protein Length Band 4.1 domain FAK1/PYK2, FERM domain C-lobe FERM/acyl-CoA-binding protein superfamily FERM central domain FERM domain FERM superfamily, second domain Focal adhesion kinase, N-terminal Focal adhesion kinase, targeting (FAT) domain Focal adhesion kinase, targeting (FAT) domain superfamily PH-like domain superfamily Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Ubiquitin-like domain superfamily
UniProtKB:A0A0R4ICT0 977
UniProtKB:A0A0R4IEL2 98
UniProtKB:A0A0R4IRT2 216
UniProtKB:B3DGP9 1045
UniProtKB:Q7T2V4 1045
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ptk2 polyclonal IgG Rabbit
  • IHC
Life Technologies (Invitrogen)
9
Ab3-ptk2 monoclonal IgG1 , k Mouse
  • WB
Santa Cruz Biotechnology, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations