ZFIN ID: ZDB-GENE-031114-5
Gene Name: protein tyrosine kinase 2aa
Gene Symbol: ptk2aa    Nomenclature History

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Previous Names: ptk2.2, fak1b (1), fakb (1), si:ch1073-355e8.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and protein tyrosine kinase activity. Involved in protein localization. Predicted to localize to the cytoskeleton; focal adhesion; and integral component of membrane. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Is expressed in head; midbrain; midbrain hindbrain boundary; and paraxial mesoderm. Orthologous to human PTK2 (protein tyrosine kinase 2).
Genome Resources: Alliance (1),  Gene:386705 (1),  Ensembl(GRCz11):ENSDARG00000100456 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
tud11Gt Transgenic Insertion 5' UTR Unknown DNA
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-ptk2aa N/A 1
MO2-ptk2aa N/A 1
MO3-ptk2aa N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ptk2aa HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH ptk2aa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process protein localization (more)
Cellular Component cytoskeleton (more)
Molecular Function ATP binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000299 FERM domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR005189 Focal adhesion kinase, targeting (FAT) domain
Active_site IPR008266 Tyrosine-protein kinase, active site
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR014352 FERM/acyl-CoA-binding protein superfamily
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR019748 FERM central domain
Domain IPR019749 Band 4.1 domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR035963 FERM superfamily, second domain
Homologous_superfamily IPR036137 Focal adhesion kinase, targeting (FAT) domain superfamily
Domain IPR041390 Focal adhesion kinase, N-terminal
Domain IPR041784 FAK1/PYK2, FERM domain C-lobe
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ptk2aa-202 (1)    Ensembl 295
ptk2aa-203 (1)    Ensembl 1150
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-ptk2 polyclonal IgG Rabbit IHC Life Technologies (Invitrogen)
9
Ab3-ptk2 monoclonal IgG1 , k Mouse WB Santa Cruz Biotechnology, Inc.
2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ptk2aa No data available
MARKER RELATIONSHIPS
ptk2aa Contained in: [BAC] CH211-149A19 (1)
ptk2aa Encodes: [cDNA] MGC:193574 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_198819 (1) 4014 bp
Genomic GenBank:CU424444 (1) 132828 bp
Select Tool
Polypeptide UniProtKB:B3DGP9 (1) 1045 aa
Sequence Clusters UniGene:147598 (1)
Sequence Information (all 26)
ORTHOLOGY for ptk2aa ( Chr: 19 )
CITATIONS (27)