Gene
ptk2ab
- ID
- ZDB-GENE-020114-1
- Name
- protein tyrosine kinase 2ab
- Symbol
- ptk2ab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in regulation of convergent extension involved in gastrulation. Acts upstream of or within with a positive effect on midbrain-hindbrain boundary morphogenesis. Acts upstream of or within lens fiber cell morphogenesis and regulation of protein localization. Predicted to be located in several cellular components, including cytoskeleton; focal adhesion; and plasma membrane. Is expressed in eye; notochord; segmental plate; somite; and vertical myoseptum. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019703Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13179 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22873 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22874 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa22875 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22876 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa36173 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa36174 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| twu0103 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| uab476 | Allele with one delins | Unknown | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR005189 | Focal adhesion kinase, targeting (FAT) domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR041390 | Focal adhesion kinase, N-terminal |
| Domain | IPR041784 | FAK1/PYK2, FERM domain C-lobe |
| Domain | IPR049385 | FAK1-like, FERM domain C-lobe |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR036137 | Focal adhesion kinase, targeting (FAT) domain superfamily |
Domain Details Per Protein
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptk2ab-201
(1)
|
Ensembl | 3,874 nt | ||
| mRNA |
ptk2ab-202
(1)
|
Ensembl | 3,299 nt | ||
| mRNA |
ptk2ab-203
(1)
|
Ensembl | 6,468 nt | ||
| mRNA |
ptk2ab-211
(1)
|
Ensembl | 5,753 nt | ||
| mRNA |
ptk2ab-212
(1)
|
Ensembl | 5,865 nt | ||
| mRNA |
ptk2ab-213
(1)
|
Ensembl | 6,036 nt | ||
| mRNA |
ptk2ab-214
(1)
|
Ensembl | 6,486 nt | ||
| mRNA |
ptk2ab-215
(1)
|
Ensembl | 5,664 nt | ||
| mRNA |
ptk2ab-216
(1)
|
Ensembl | 6,015 nt | ||
| ncRNA |
ptk2ab-002
(1)
|
Ensembl | 845 nt | ||
| ncRNA |
ptk2ab-003
(1)
|
Ensembl | 885 nt | ||
| ncRNA |
ptk2ab-005
(1)
|
Ensembl | 768 nt | ||
| ncRNA |
ptk2ab-006
(1)
|
Ensembl | 645 nt | ||
| ncRNA |
ptk2ab-008
(1)
|
Ensembl | 537 nt | ||
| ncRNA |
ptk2ab-009
(1)
|
Ensembl | 808 nt | ||
| ncRNA |
ptk2ab-011
(1)
|
Ensembl | 722 nt |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ptk2 | polyclonal | IgG | Rabbit |
|
Life Technologies (Invitrogen)
|
11 | |
| Ab1-ptk2.1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
5 |
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-123P18 | ZFIN Curated Data | |
| Contained in | BAC | CH211-198D13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-199K9 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-338M3 | ZFIN Curated Data | |
| Encodes | EST | fa18c04 | ||
| Encodes | cDNA | MGC:66114 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195313 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131796 (1) | 3895 nt | ||
| Genomic | GenBank:CT029997 (1) | 171681 nt | ||
| Polypeptide | UniProtKB:A0A8M9P7Q1 (1) | 1142 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Ablain, J., Al Mahi, A., Rothschild, H., Prasad, M., Aires, S., Yang, S., Dokukin, M.E., Xu, S., Dang, M., Sokolov, I., Lian, C.G., Zon, L.I. (2022) Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. Nature Genetics. 54(12):1839-1852
- Hung, I.C., Chen, T.M., Lin, J.P., Tai, Y.L., Shen, T.L., Lee, S.J. (2020) Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42. Open Biology. 10:190273
- Rho, S.S., Kobayashi, I., Oguri-Nakamura, E., Ando, K., Fujiwara, M., Kamimura, N., Hirata, H., Iida, A., Iwai, Y., Mochizuki, N., Fukuhara, S. (2019) Rap1b Promotes Notch-Signal-Mediated Hematopoietic Stem Cell Development by Enhancing Integrin-Mediated Cell Adhesion. Developmental Cell. 49(5):681-696.e6
- Gutzman, J.H., Graeden, E., Brachmann, I., Yamazoe, S., Chen, J.K., Sive, H. (2018) Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase. Biology Open. 7(11):
- Kara, N., Wei, C., Commanday, A.C., Patton, J.G. (2017) miR-27 regulates chondrogenesis by suppressing Focal Adhesion Kinase during pharyngeal arch development. Developmental Biology. 429(1):321-334
- Yu, S., Li, C., Biswas, L., Hu, X., Liu, F., Reilly, J., Liu, X., Liu, Y., Huang, Y., Lu, Z., Han, S., Wang, L., Liu, J.Y., Jiang, T., Shu, X., Wong, F., Tang, Z., Liu, M. (2017) CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Human molecular genetics. 26(12):2335-2345
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Hirth, S., Bühler, A., Bührdel, J.B., Rudeck, S., Dahme, T., Rottbauer, W., Just, S. (2016) Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS One. 11:e0150323
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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