Gene

ptk2ab

ID
ZDB-GENE-020114-1
Name
protein tyrosine kinase 2ab
Symbol
ptk2ab Nomenclature History
Previous Names
  • fak1a (1)
  • faka (1)
  • ptk2.1
  • ptk2 (1)
  • fak (1)
  • focal adhesion kinase (1)
  • wu:fa18c04
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in lens fiber cell morphogenesis and midbrain-hindbrain boundary morphogenesis. Predicted to localize to dendritic spine; extrinsic component of cytoplasmic side of plasma membrane; and focal adhesion. Is expressed in eye; notochord; segmental plate; somite; and vertical myoseptum. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptk2ab Human Ortholog
No data available
Associated With ptk2ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000299 FERM domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR005189 Focal adhesion kinase, targeting (FAT) domain
Domain IPR019748 FERM central domain
Domain IPR019749 Band 4.1 domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR041390 Focal adhesion kinase, N-terminal
Domain IPR041784 FAK1/PYK2, FERM domain C-lobe
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR014352 FERM/acyl-CoA-binding protein superfamily
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR035963 FERM superfamily, second domain
Homologous_superfamily IPR036137 Focal adhesion kinase, targeting (FAT) domain superfamily
Domain Details Per Protein
Protein Length Band 4.1 domain FAK1/PYK2, FERM domain C-lobe FERM/acyl-CoA-binding protein superfamily FERM central domain FERM domain FERM superfamily, second domain Focal adhesion kinase, N-terminal Focal adhesion kinase, targeting (FAT) domain Focal adhesion kinase, targeting (FAT) domain superfamily PH-like domain superfamily Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Ubiquitin-like domain superfamily
UniProtKB:A0A2R8RR02 1101
UniProtKB:A0A2R8Q5G0 1088
UniProtKB:A0A2R8QMF1 1063
UniProtKB:Q7SXQ6 280
UniProtKB:Q98SN4 1050
UniProtKB:F1QT14 1050
UniProtKB:A0A2R8RPC3 1099
UniProtKB:E7F1F9 1095
UniProtKB:B3DKK9 1050
UniProtKB:A0A2R8QKV3 1095
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ptk2 polyclonal IgG Rabbit
  • IHC
Life Technologies (Invitrogen)
9
Ab1-ptk2.1 polyclonal IgG Rabbit
  • IHC
Santa Cruz Biotechnology, Inc.
5
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations