ZFIN is now using GRCz12tu for Genomic Data
Gene
ptk2ab
- ID
- ZDB-GENE-020114-1
- Name
- protein tyrosine kinase 2ab
- Symbol
- ptk2ab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in regulation of convergent extension involved in gastrulation. Acts upstream of or within with a positive effect on midbrain-hindbrain boundary morphogenesis. Acts upstream of or within lens fiber cell morphogenesis and regulation of protein localization. Predicted to be located in focal adhesion and plasma membrane. Is expressed in eye; notochord; segmental plate; somite; and vertical myoseptum. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR005189 | Focal adhesion kinase, targeting (FAT) domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR019749 | Band 4.1 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR041390 | Focal adhesion kinase, N-terminal |
| Domain | IPR041784 | FAK1/PYK2, FERM domain C-lobe |
| Domain | IPR049385 | FAK1-like, FERM domain C-lobe |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR014352 | FERM/acyl-CoA-binding protein superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR036137 | Focal adhesion kinase, targeting (FAT) domain superfamily |
Domain Details Per Protein
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptk2ab-201
(1)
|
Ensembl | 3,874 nt | ||
| mRNA |
ptk2ab-202
(1)
|
Ensembl | 3,299 nt | ||
| mRNA |
ptk2ab-203
(1)
|
Ensembl | 6,468 nt | ||
| mRNA |
ptk2ab-211
(1)
|
Ensembl | 5,753 nt | ||
| mRNA |
ptk2ab-212
(1)
|
Ensembl | 5,865 nt | ||
| mRNA |
ptk2ab-213
(1)
|
Ensembl | 6,036 nt | ||
| mRNA |
ptk2ab-214
(1)
|
Ensembl | 6,486 nt | ||
| mRNA |
ptk2ab-215
(1)
|
Ensembl | 5,664 nt | ||
| mRNA |
ptk2ab-216
(1)
|
Ensembl | 6,015 nt | ||
| ncRNA |
ptk2ab-002
(1)
|
Ensembl | 845 nt | ||
| ncRNA |
ptk2ab-003
(1)
|
Ensembl | 885 nt | ||
| ncRNA |
ptk2ab-005
(1)
|
Ensembl | 768 nt | ||
| ncRNA |
ptk2ab-006
(1)
|
Ensembl | 645 nt | ||
| ncRNA |
ptk2ab-008
(1)
|
Ensembl | 537 nt | ||
| ncRNA |
ptk2ab-009
(1)
|
Ensembl | 808 nt | ||
| ncRNA |
ptk2ab-011
(1)
|
Ensembl | 722 nt |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ptk2 | polyclonal | IgG | Rabbit |
|
Life Technologies (Invitrogen)
|
11 | |
| Ab1-ptk2.1 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
5 |
Plasmids
No data available
- Genome Browsers