Gene
gad2
- ID
- ZDB-GENE-030909-9
- Name
- glutamate decarboxylase 2
- Symbol
- gad2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to have glutamate decarboxylase activity and pyridoxal phosphate binding activity. Involved in gamma-aminobutyric acid biosynthetic process. Human ortholog(s) of this gene implicated in gestational diabetes; schizophrenia; and type 1 diabetes mellitus. Is expressed in central nervous system; eye; and neurons. Orthologous to human GAD2 (glutamate decarboxylase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 29 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from O'Connor et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR021115 | Pyridoxal-phosphate binding site |
| Family | IPR002129 | Pyridoxal phosphate-dependent decarboxylase |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Length | Pyridoxal-phosphate binding site | Pyridoxal phosphate-dependent decarboxylase | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PG03
|
478 | ||||
|
UniProtKB:F1R9E8
|
583 |
Interactions and Pathways
No data available
Plasmids
No data available