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ZIRC
ZFIN ID: ZDB-GENE-030819-1
Gene Name: tumor protein p63
Gene Symbol: tp63    Nomenclature History

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Previous Names: p63 (1), delta-Np63 (1), fc89f04, id:ibd3516 (1), tp73l (1), wu:fc89f04, wu:fk85h07, wu:fk88b02 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Exhibits DNA binding activity. Involved in several processes, including epidermis morphogenesis; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and negative regulation of transcription, DNA-templated. Localizes to the nucleus. Human ortholog(s) of this gene implicated in several diseases, including ADULT syndrome; EEC syndrome (multiple); Rapp-Hodgkin syndrome; ankyloblepharon-ectodermal defects-cleft lip/palate syndrome; and orofacial cleft 8. Is expressed in several structures, including ectoderm; epiblast; integument; pharynx; and pleuroperitoneal region. Orthologous to human TP63 (tumor protein p63).
Genome Resources: Alliance (1),  Gene:260407 (1),  Ensembl(GRCz11):ENSDARG00000044356 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2525 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la015877Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la025475Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029208Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029209Tg Transgenic Insertion Unknown Unknown DNA
    sa12599 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15970 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33878 Point Mutation Unknown Missense, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tp63
    1
    MO1-tp63 N/A 6
    MO2-tp63 N/A 6
    MO3-tp63 N/A 3
    MO4-tp63 N/A 1
    MO5-tp63 N/A 1
    MO6-tp63 N/A 1
    MO7-tp63 N/A 1
    DISEASE ASSOCIATED WITH tp63 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ADULT syndrome Alliance ADULT syndrome 103285
    ankyloblepharon-ectodermal defects-cleft lip/palate syndrome Alliance Hay-Wells syndrome 106260
    ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 Alliance Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 604292
    orofacial cleft 8 Alliance Orofacial cleft 8 618149
    Rapp-Hodgkin syndrome Alliance Rapp-Hodgkin syndrome 129400
    split hand-foot malformation 4 Alliance Split-hand/foot malformation 4 605289
    Limb-mammary syndrome 603543
    DISEASE ASSOCIATED WITH tp63 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 15)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tp63-201 (1)    Ensembl 2783
    tp63-202 (1)    Ensembl 2959
    tp63-203 (1)    Ensembl 1444
    tp63-204 (1)    Ensembl 2497
    tp63-205 (1)    Ensembl 1731
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tp63 monoclonal IgG2a , k Mouse IHC Santa Cruz Biotechnology, Inc.
    Millipore
    Novus Biologicals, LLC
    Biocare
    45
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tp63
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(tp63:CAAX-GFP) tp63 CAAXGFP Danio rerio 1 1
    Tg(tp63:DsRed) tp63 DsRed Danio rerio 1 1
    Tg(tp63:GAL4,UAS:GFP) tp63UAS GAL4GFP Danio rerio 1 3
    tg(tp63:mcherry-2a-cre-ert2) tp63 2ACreERT2mCherry Danio rerio 1 1
    TgBAC(tp63:GAL4FF) tp63 GAL4FF Danio rerio 1 4
    MARKER RELATIONSHIPS
    tp63 Contained in: [BAC] CH211-240D20 (order this), DKEY-11H2 (1) (order this), DKEY-13D19 (1) (order this)
    tp63 Encodes: [EST] eu912 (1), fc89f04, fk85h07 (1), fk88b02 (1), ibd3516 (1) (order this)
    [cDNA] MGC:92012 (1) (order this), MGC:174146 (1) (order this), MGC:192897 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152986 (1) 3004 bp
    Genomic GenBank:BX004878 (1) 254657 bp Blast at MegaBLAST
    Polypeptide UniProtKB:E9QG65 (1) 632 aa
    Sequence Clusters UniGene:32588 (1)
    Sequence Information (all 55)
    ORTHOLOGY for tp63 ( Chr: 6 )
    CITATIONS (98)