Gene

tp63

ID
ZDB-GENE-030819-1
Name
tumor protein p63
Symbol
tp63 Nomenclature History
Previous Names
  • p63 (1)
  • delta-Np63 (1)
  • fc89f04
  • id:ibd3516 (1)
  • tp73l (1)
  • wu:fc89f04
  • wu:fk85h07
  • wu:fk88b02 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Enables DNA binding activity. Acts upstream of or within several processes, including epidermis morphogenesis; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including ectoderm; epiblast; integument; pharynx; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including ADULT syndrome; EEC syndrome (multiple); ectodermal dysplasia (multiple); orofacial cleft 8; and split hand-foot malformation 4. Orthologous to human TP63 (tumor protein p63).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
61 figures from 37 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tp63 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ADULT syndrome Alliance ADULT syndrome 103285
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome Alliance Hay-Wells syndrome 106260
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 Alliance Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 604292
orofacial cleft 8 Alliance Orofacial cleft 8 618149
Rapp-Hodgkin syndrome Alliance Rapp-Hodgkin syndrome 129400
split hand-foot malformation 4 Alliance Split-hand/foot malformation 4 605289
Limb-mammary syndrome 603543
Associated With tp63 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001660 Sterile alpha motif domain
Domain IPR010991 p53, tetramerisation domain
Domain IPR011615 p53, DNA-binding domain
Domain IPR037611 Tumour protein p63, SAM domain
Family IPR002117 p53 tumour suppressor family
Family IPR032645 Tumour protein p63
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamily
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR036674 p53-like tetramerisation domain superfamily
Domain Details Per Protein
Protein Length p53, DNA-binding domain p53-like tetramerisation domain superfamily p53-like transcription factor, DNA-binding p53/RUNT-type transcription factor, DNA-binding domain superfamily p53, tetramerisation domain p53 tumour suppressor family Sterile alpha motif domain Sterile alpha motif/pointed domain superfamily Tumour protein p63 Tumour protein p63, SAM domain
UniProtKB:F1QKD5 588
UniProtKB:Q8JHZ5 457
UniProtKB:W8Q8J6 527
UniProtKB:A7YYJ7 588
UniProtKB:Q8JFE3 576
UniProtKB:A0A0R4IHL8 527
UniProtKB:A0A0R4IZ80 490
UniProtKB:W8Q7P2 490
UniProtKB:A0A2R8PYJ9 437
UniProtKB:E9QG65 632
UniProtKB:F1QLJ1 439
UniProtKB:Q6DG24 434
UniProtKB:Q8JHZ6 588
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tp63 monoclonal IgG2a , k Mouse
  • IHC
Biocare
Santa Cruz Biotechnology, Inc.
Millipore
Novus Biologicals, LLC
47
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations